Gene: SYNE1

23345
8B|ARCA1|C6orf98|CPG2|EDMD4|KASH1|MYNE1|Nesp1|SCAR8|dJ45H2.2
spectrin repeat containing nuclear envelope protein 1
protein-coding
6q25.2
Ensembl:ENSG00000131018 MIM:608441 Vega:OTTHUMG00000015841 UniprotKB:Q8NF91
NG_012855.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.748e-2 (AD)  7.901e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LONP20.917
TRAK10.916
ASTN10.914
CLASP10.912
KIAA16710.902
SIPA1L10.898
LDB10.895
KIAA03190.893
MTOR0.893
MAST40.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.555
OR4F29-0.511
SGMS2-0.443
GNG8-0.438
CTNNA3-0.428
SH2D1A-0.421
ANXA13-0.414
HAS2-0.401
CD8B-0.401
TFPI2-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SYNE1 mRNA"25270620
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SYNE1 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SYNE1 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of SYNE1 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of SYNE1 mRNA"19799885
D000082AcetaminophenAcetaminophen results in decreased expression of SYNE1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SYNE1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of SYNE1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SYNE1 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SYNE1 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYNE1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SYNE1 mRNA24449571
D001151ArsenicArsenic affects the methylation of SYNE1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SYNE1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of SYNE1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of SYNE1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SYNE1 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SYNE1 mRNA20660070
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNE1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SYNE1 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of SYNE1 gene22576693
C006780bisphenol Abisphenol A affects the expression of SYNE1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of SYNE1 mRNA22079614
D002509CephaloridineCephaloridine results in decreased expression of SYNE1 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SYNE1 mRNA25270620
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SYNE1 mRNA26272509
D002994ClofibrateClofibrate affects the expression of SYNE1 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased expression of SYNE1 mRNA24386269
D003042CocaineCocaine results in increased expression of SYNE1 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYNE1 mRNA]18355967
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SYNE1 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of SYNE1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SYNE1 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of SYNE1 mRNA21955143
D003907DexamethasoneDexamethasone results in decreased expression of SYNE1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNE1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SYNE1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SYNE1 mRNA27392435
D000431EthanolEthanol results in increased expression of SYNE1 mRNA21955143
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SYNE1 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SYNE1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of SYNE1 mRNA19167457
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNE1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SYNE1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SYNE1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SYNE1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SYNE1 mRNA23086925|2675264
D007854LeadLead results in decreased expression of SYNE1 mRNA19921347
C008261lead acetatelead acetate affects the expression of SYNE1 mRNA21147602
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of SYNE1 mRNA"24972896
C042720mercuric bromidemercuric bromide results in increased expression of SYNE1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of SYNE1 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SYNE1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SYNE1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SYNE1 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of SYNE1 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SYNE1 mRNA23876855
D009020MorphineMorphine results in increased expression of SYNE1 mRNA21955143
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of SYNE1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SYNE1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SYNE1 mRNA"25554681
D009532NickelNickel results in decreased expression of SYNE1 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of SYNE1 mRNA22110744
C028007nickel monoxidenickel monoxide affects the expression of SYNE1 mRNA19167457
D009538NicotineNicotine results in decreased expression of SYNE1 mRNA21955143
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SYNE1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SYNE1 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SYNE1 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of SYNE1 mRNA19095052
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SYNE1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of SYNE1 mRNA25270620
C006253pirinixic acidpirinixic acid results in increased expression of SYNE1 mRNA12832660
D011192Potassium DichromatePotassium Dichromate results in increased expression of SYNE1 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of SYNE1 mRNA23012394
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SYNE1 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of SYNE1 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of SYNE1 mRNA25888808
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SYNE1 mRNA25895662
D012834SilverSilver results in increased expression of SYNE1 mRNA27131904
C016104sodium bichromatesodium bichromate affects the expression of SYNE1 mRNA22110744
D013739TestosteroneTestosterone results in increased expression of SYNE1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SYNE1 mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SYNE1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SYNE1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SYNE1 mRNA22808131
D013853ThioacetamideThioacetamide results in decreased expression of SYNE1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SYNE1 mRNA19969065
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SYNE1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SYNE1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SYNE1 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SYNE1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of SYNE1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNE1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SYNE1 mRNA23179753|2438349
C025643vinclozolinvinclozolin results in increased expression of SYNE1 mRNA23034163
D015032ZincZinc deficiency results in increased expression of SYNE1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003779actin binding-IDA12408964  
GO:0005515protein binding-IPI12812986  18396275  22632968  
GO:0005521lamin binding-IPI11801724  
GO:0019899enzyme binding-IPI24862572  
GO:0042803protein homodimerization activity-ISS-  
GO:0051015actin filament binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006997nucleus organization-NAS11792814  
GO:0007030Golgi organization-IDA12808039  
GO:0007283spermatogenesis-IEA-  
GO:0042692muscle cell differentiation-IDA11792814  
GO:0090286cytoskeletal anchoring at nuclear membrane-IDA18396275  
GO:0090292nuclear matrix anchoring at nuclear membrane-IDA11801724  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IDA24862572  
GO:0005634nucleus-HDA21630459  
GO:0005635nuclear envelope-IDA11792814  
GO:0005640nuclear outer membrane-IEA-  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA24862572  
GO:0005737cytoplasm-IDA11792814  
GO:0005794Golgi apparatus-IDA12808039  
GO:0005856cytoskeleton-IEA-  
GO:0016021integral component of membrane-IDA11792814  
GO:0030017sarcomere-IDA12408964  
GO:0031965nuclear membrane-IDA-  
GO:0034993meiotic nuclear membrane microtubule tethering complex-IDA18396275  
GO:0045211postsynaptic membrane-IDA10878022  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res
18339850Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. (2008 Mar 15)Tessema MCancer Res