Gene: PSD3

23362
EFA6D|EFA6R|HCA67
pleckstrin and Sec7 domain containing 3
protein-coding
8p22
Ensembl:ENSG00000156011 MIM:614440 Vega:OTTHUMG00000163711 UniprotKB:Q9NYI0
NC_000008.11
PubMed|SNP Mapped
1   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.337e-1 (AD)  4.025e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6999315chr8:18937535 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDPK10.964
FRRS1L0.958
ARHGEF90.951
ITPR10.95
RAPGEF20.95
INPP4A0.947
NCKAP10.946
CNKSR20.946
THRB0.943
PTPN40.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.506
CSAG1-0.484
OR4F29-0.463
TFPI2-0.44
HEY2-0.433
MYL3-0.428
FLT3LG-0.426
SNHG18-0.425
SH2D1A-0.408
COPZ2-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PSD3 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSD3 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PSD3 mRNA"23146750
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PSD3 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of PSD3 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PSD3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PSD3 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of PSD3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PSD3 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PSD3 mRNA21298039
D001151ArsenicArsenic affects the methylation of PSD3 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PSD3 mRNA19128835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PSD3 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PSD3 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PSD3 mRNA"20382639
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PSD3 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of PSD3 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of PSD3 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PSD3 mRNA29097150
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PSD3 mRNA15336504
C018021cobaltous chloridecobaltous chloride results in decreased expression of PSD3 mRNA24386269
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA]21370964
D019327Copper SulfateCopper Sulfate results in increased expression of PSD3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of PSD3 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of PSD3 mRNA25562108
D003561CytarabineCytarabine results in increased expression of PSD3 mRNA21198554
D003703DemecolcineDemecolcine results in increased expression of PSD3 mRNA23649840
D002945CisplatinCisplatin results in decreased expression of PSD3 mRNA19561079
D004041Dietary FatsDietary Fats results in decreased expression of PSD3 mRNA25016146
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PSD3 mRNA22129741
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PSD3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PSD3 mRNA29097150
D005557FormaldehydeFormaldehyde results in increased expression of PSD3 mRNA23649840
D017313FenretinideFenretinide results in decreased expression of PSD3 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PSD3 mRNA17183730
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of PSD3 mRNA22129741
D008070Lipopolysaccharidescoenzyme Q10 inhibits the reaction [Lipopolysaccharides results in increased expression of PSD3 mRNA]21370964
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PSD3 mRNA21370964
D008558MelphalanMelphalan results in decreased expression of PSD3 mRNA22363485
D008694MethamphetaminePSD3 gene SNP affects the susceptibility to Methamphetamine18316681
D008694MethamphetamineMethamphetamine results in increased expression of PSD3 mRNA26307267
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PSD3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PSD3 mRNA"25554681
D009532NickelNickel results in decreased expression of PSD3 mRNA24768652
C029938nickel sulfatenickel sulfate results in decreased expression of PSD3 mRNA22714537
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PSD3 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PSD3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PSD3 mRNA26272509
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PSD3 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in decreased expression of PSD3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PSD3 mRNA21632981
D012834SilverSilver results in decreased expression of PSD3 mRNA27131904
D013629TamoxifenTamoxifen affects the expression of PSD3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSD3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PSD3 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSD3 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSD3 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PSD3 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of PSD3 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of PSD3 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of PSD3 mRNA24935251
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PSD3 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of PSD3 gene29154799
D014638VanadatesVanadates results in increased expression of PSD3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PSD3 gene25560391
D014750VincristineVincristine results in increased expression of PSD3 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of PSD3 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005086ARF guanyl-nucleotide exchange factor activity-IBA21873635  
GO:0005086ARF guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032012regulation of ARF protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0032587ruffle membrane-IBA21873635  
GO:0032587ruffle membrane-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28607459The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. (2018 Mar)Gonzalez DAMol Psychiatry