Gene: PUM2

23369
PUMH2|PUML2
pumilio RNA binding family member 2
protein-coding
2p24.1
Ensembl:ENSG00000055917 MIM:607205 Vega:OTTHUMG00000122098 UniprotKB:Q8TB72
NC_000002.12
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.746e-2 (AD)  1.324e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPIN10.951
RPRD1A0.945
ZMYM40.942
TBL1XR10.942
CAMSAP20.941
PTEN0.941
PUM10.939
GNAQ0.939
ATF20.935
CALM10.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.703
OR4F29-0.666
CSAG1-0.324
TFPI2-0.314
PDZK1IP1-0.286
AHSP-0.276
SNHG18-0.269
FLT3LG-0.268
C9orf135-0.266
ACAP1-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PUM2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PUM2 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PUM2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PUM2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PUM2 mRNA19770486
D001241AspirinAspirin results in increased expression of PUM2 mRNA15928584
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PUM2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PUM2 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PUM2 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of PUM2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PUM2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PUM2 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PUM2 mRNA21297351
D019327Copper SulfateCopper Sulfate results in decreased expression of PUM2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PUM2 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA28628672
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of PUM2 mRNA"25908611
D004041Dietary FatsDietary Fats results in increased expression of PUM2 mRNA25016146
D004317DoxorubicinDoxorubicin results in increased expression of PUM2 mRNA17888722
D005557FormaldehydeFormaldehyde results in decreased expression of PUM2 mRNA20655997
D005839GentamicinsGentamicins results in increased expression of PUM2 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of PUM2 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of PUM2 mRNA16807920
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PUM2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PUM2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PUM2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PUM2 mRNA26794494
C045950propiconazolepropiconazole results in decreased expression of PUM2 mRNA21278054
D013629TamoxifenTamoxifen affects the expression of PUM2 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PUM2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PUM2 mRNA25975270
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PUM2 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of PUM2 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of PUM2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PUM2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PUM2 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of PUM2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PUM2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PUM2 mRNA20566332
D002762CholecalciferolCholecalciferol results in increased expression of PUM2 mRNA16508948

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IDA26724866  
GO:0003730mRNA 3'-UTR binding-IDA18776931  
GO:0005515protein binding-IPI12511597  19168546  21800163  22190034  23125361  25340845  
GO:0035198miRNA binding-IDA28431233  
GO ID GO Term Qualifier Evidence PubMed
GO:0006417regulation of translation-IEA-  
GO:0010608posttranscriptional regulation of gene expression-IDA25100735  
GO:0010608posttranscriptional regulation of gene expression-IMP28431233  
GO:0034063stress granule assembly-IEA-  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IMP28431233  
GO:0043488regulation of mRNA stability-IDA26724866  
GO:0051983regulation of chromosome segregation-IDA26724866  
GO:0060964regulation of gene silencing by miRNA-TAS18776931  
GO:1900246positive regulation of RIG-I signaling pathway-IDA25340845  
GO:2000637positive regulation of gene silencing by miRNA-IMP22345517  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0010494cytoplasmic stress granule-IDA25340845  
GO:0010494cytoplasmic stress granule-ISS-  
GO:0031965nuclear membrane-IDA-  
GO:0048471perinuclear region of cytoplasm-IDA19168546  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26944283Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. (2017 Apr)Sadakierska-Chudy AMol Neurobiol