Gene: ARHGEF18

23370
P114-RhoGEF|RP78
Rho/Rac guanine nucleotide exchange factor 18
protein-coding
19p13.2
Ensembl:ENSG00000104880 MIM:616432 Vega:OTTHUMG00000177342 UniprotKB:Q6ZSZ5
NG_047135.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.972e-1 (AD)  7.201e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2287919chr19:7464529 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12610760chr19:7451357 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7248066chr19:7445470 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2820.942
ZC3H180.925
UPF10.922
SMG50.921
SCAP0.921
U2AF20.92
SYVN10.92
SMPD40.918
KHSRP0.917
PTPN230.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.683
OR4F29-0.638
KLRB1-0.348
ARHGEF35-0.341
GZMK-0.332
KLRF1-0.332
CEACAM3-0.326
FMO1-0.325
IL18RAP-0.324
SDR42E1-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ARHGEF18 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of ARHGEF18 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ARHGEF18 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARHGEF18 mRNA24449571
D001151ArsenicArsenic affects the methylation of ARHGEF18 gene25304211
C058317arsenic disulfidearsenic disulfide results in decreased expression of ARHGEF18 mRNA12890387
D001280AtrazineAtrazine results in increased expression of ARHGEF18 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGEF18 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARHGEF18 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGEF18 mRNA"19150397|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of ARHGEF18 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ARHGEF18 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGEF18 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ARHGEF18 promoter22457795
D019327Copper SulfateCopper Sulfate results in increased expression of ARHGEF18 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ARHGEF18 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of ARHGEF18 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ARHGEF18 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ARHGEF18 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of ARHGEF18 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of ARHGEF18 mRNA21592394
D004147DioxinsDioxins affects the expression of ARHGEF18 mRNA20463971
D004237DiuronDiuron results in increased expression of ARHGEF18 mRNA21551480
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF18 mRNA17942748
D018120FinasterideFinasteride results in increased expression of ARHGEF18 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of ARHGEF18 mRNA19167457
C039281furanfuran results in increased methylation of ARHGEF18 gene22079235
D005839GentamicinsGentamicins results in increased expression of ARHGEF18 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGEF18 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARHGEF18 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARHGEF18 mRNA25982114
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARHGEF18 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ARHGEF18 mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ARHGEF18 mRNA"12756304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ARHGEF18 mRNA25729387
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of ARHGEF18 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of ARHGEF18 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGEF18 mRNA20067830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGEF18 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARHGEF18 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGEF18 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGEF18 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of ARHGEF18 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ARHGEF18 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ARHGEF18 mRNA25729387
D014520UrethaneUrethane results in increased expression of ARHGEF18 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of ARHGEF18 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of ARHGEF18 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ARHGEF18 gene25560391
D019287Zinc SulfateZinc Sulfate results in increased expression of ARHGEF18 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005085guanyl-nucleotide exchange factor activity-IDA14512443  
GO:0005085guanyl-nucleotide exchange factor activity-TAS-  
GO:0005089Rho guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007264small GTPase mediated signal transduction-IDA14512443  
GO:0008360regulation of cell shape-IDA14512443  
GO:0030036actin cytoskeleton organization-IDA14512443  
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO:0043065positive regulation of apoptotic process-TAS-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-TAS-  
GO:0045177apical part of cell-IDA22006950  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-193648NRAGE signals death through JNKTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)IEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal