Gene: AHCYL2

23382
ADOHCYASE3|IRBIT2
adenosylhomocysteinase like 2
protein-coding
7q32.1
Ensembl:ENSG00000158467 MIM:616520 Vega:OTTHUMG00000157677 UniprotKB:Q96HN2
NG_029180.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.208e-2 (AD)  1.401e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEBL0.897
ABLIM10.89
EIF4EBP20.884
SLC41A10.881
DAG10.878
NTRK20.875
DOCK70.874
ATP1A20.874
MSI20.865
MAP3K50.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.593
OR4F29-0.568
C17orf112-0.272
L1TD1-0.266
STMND1-0.266
KLK8-0.265
CD8B-0.263
GNG8-0.26
MUSK-0.259
GAL-0.252

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of AHCYL2 mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of AHCYL2 mRNA16788091
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to AHCYL2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AHCYL2 protein]26598702
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AHCYL2 protein]26598702
D001280AtrazineAtrazine results in increased expression of AHCYL2 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of AHCYL2 mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AHCYL2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AHCYL2 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of AHCYL2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AHCYL2 mRNA26238291
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AHCYL2 mRNA27858113
C006780bisphenol Abisphenol A affects the expression of AHCYL2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AHCYL2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of AHCYL2 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of AHCYL2 protein28903499
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of AHCYL2 mRNA27858113
D016572CyclosporineCyclosporine results in increased expression of AHCYL2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AHCYL2 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of AHCYL2 mRNA25242112
D004147DioxinsDioxins affects the expression of AHCYL2 mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of AHCYL2 mRNA20530235
D016291Dizocilpine MaleateDizocilpine Maleate results in increased expression of AHCYL2 protein21297352
D017313FenretinideFenretinide results in decreased expression of AHCYL2 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AHCYL2 mRNA24796395
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AHCYL2 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of AHCYL2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AHCYL2 mRNA"25554681
C006253pirinixic acidpirinixic acid results in decreased expression of AHCYL2 mRNA20813756
D010936Plant ExtractsPlant Extracts results in increased expression of AHCYL2 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AHCYL2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of AHCYL2 mRNA19073995
D012999SomanSoman results in decreased expression of AHCYL2 mRNA19281266
D053260SootSoot results in increased expression of AHCYL2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AHCYL2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AHCYL2 mRNA22298810
D013893ThiramThiram results in decreased expression of AHCYL2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of AHCYL2 mRNA16788091
D014415TunicamycinTunicamycin results in increased expression of AHCYL2 mRNA22378314
D014520UrethaneUrethane results in increased expression of AHCYL2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of AHCYL2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of AHCYL2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AHCYL2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of AHCYL2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004013adenosylhomocysteinase activity-IBA21873635  
GO:0004013adenosylhomocysteinase activityNOTIBA21873635  
GO:0005515protein binding-IPI19220705  
GO ID GO Term Qualifier Evidence PubMed
GO:0006730one-carbon metabolic process-IEA-  
GO:0033353S-adenosylmethionine cycle-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28151741Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides. (2017 May)Mostafavi NEpidemiology