Gene: SIK3

23387
L19|QSK|SIK-3
SIK family kinase 3
protein-coding
11q23.3
Ensembl:ENSG00000160584 MIM:614776 Vega:OTTHUMG00000066628 UniprotKB:Q9Y2K2
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.274e-2 (AD)  4.221e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10502221chr11:116956154 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19006628chr11:116827516SIK3Gene body1.562e-5Alcohol use disorders26763658
cg01218206chr11:116933977SIK33.100e-23Smoking27651444
cg17464820chr11:116838417SIK32.930e-9Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPO60.914
GATAD2B0.904
MAU20.9
TRPC4AP0.898
NFASC0.898
ARHGAP10.897
PTK20.89
POGZ0.888
NCAM10.888
EZH10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.618
OR4F16-0.32
MTRNR2L9-0.296
MTRNR2L6-0.286
MTRNR2L10-0.263
TTLL10-0.259
MTRNR2L8-0.252
IFNG-0.25
GZMK-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIK3 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of SIK3 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIK3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SIK3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SIK3 mRNA24449571
D001151ArsenicArsenic affects the methylation of SIK3 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SIK3 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SIK3 mRNA26238291
C006780bisphenol Abisphenol A affects the expression of SIK3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SIK3 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of SIK3 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of SIK3 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of SIK3 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in increased expression of SIK3 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of SIK3 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SIK3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SIK3 mRNA19561079|2759478
C000944dicrotophosdicrotophos results in increased expression of SIK3 mRNA28302478
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of SIK3 mRNA27638505
D005485FlutamideFlutamide results in decreased expression of SIK3 mRNA24136188
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of SIK3 mRNA24680724
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SIK3 mRNA21641980
D008727MethotrexateMethotrexate results in decreased expression of SIK3 mRNA24449571
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to SIK3 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SIK3 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SIK3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SIK3 mRNA"25554681
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SIK3 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of SIK3 mRNA23892564
C045950propiconazolepropiconazole results in decreased expression of SIK3 mRNA21278054
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SIK3 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIK3 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SIK3 promoter]19654925
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SIK3 mRNA20133372
C066340tolcaponetolcapone results in increased expression of SIK3 mRNA24136188
C057693troglitazonetroglitazone results in decreased expression of SIK3 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SIK3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SIK3 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of SIK3 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SIK3 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SIK3 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA14976552  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA14976552  
GO:0005515protein binding-IPI16306228  
GO:0005524ATP binding-IDA14976552  
GO:0050321tau-protein kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0006468protein phosphorylation-IDA14976552  
GO:0035556intracellular signal transduction-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal