Gene: LARS2

23395
HLASA|LEURS|PRLTS4|mtLeuRS
leucyl-tRNA synthetase 2, mitochondrial
protein-coding
3p21.31
Ensembl:ENSG00000011376 MIM:604544 Vega:OTTHUMG00000133177 UniprotKB:Q15031
NG_033907.1
PubMed
0   ANCO-SNPs
ND
1   
2.690e-1 (AD)  7.917e-1 (ND)   (Frontal_Cortex)
2.168e-1 (AD)  4.295e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C20orf1940.816
ACO20.804
MLEC0.802
AGPAT30.802
MINK10.801
MTMR30.801
GPR1070.795
SLC41A10.788
LRP10.787
TK20.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.647
OR4F29-0.611
C17orf112-0.315
GZMK-0.312
WDR72-0.308
GADL1-0.302
FMO1-0.277
IL24-0.269
GSDMA-0.267
OR6C74-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of LARS2 mRNA21420995|2570463
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LARS2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LARS2 mRNA21298039
D000638AmiodaroneAmiodarone results in increased expression of LARS2 mRNA24489787
D001280AtrazineAtrazine results in decreased expression of LARS2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LARS2 mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LARS2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LARS2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LARS2 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of LARS2 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of LARS2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of LARS2 mRNA23798566
C006780bisphenol Abisphenol A results in increased expression of LARS2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LARS2 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LARS2 mRNA24374135
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LARS2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of LARS2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of LARS2 mRNA20106945|2556210
D005485FlutamideFlutamide results in increased expression of LARS2 mRNA24136188
C004312glycidolglycidol results in increased expression of LARS2 mRNA24915197
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LARS2 mRNA20971185
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LARS2 protein26879310
C006253pirinixic acidpirinixic acid results in decreased expression of LARS2 mRNA16940010
D012822Silicon DioxideSilicon Dioxide results in increased expression of LARS2 mRNA25351596
D012999SomanSoman results in decreased expression of LARS2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LARS2 mRNA11489354
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LARS2 mRNA21570461|2892240
D019284ThapsigarginThapsigargin results in decreased expression of LARS2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of LARS2 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of LARS2 mRNA28973375
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LARS2 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of LARS2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of LARS2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002161aminoacyl-tRNA editing activity-IEA-  
GO:0004823leucine-tRNA ligase activity-IBA21873635  
GO:0004823leucine-tRNA ligase activity-IDA10684970  26537577  
GO:0004823leucine-tRNA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006429leucyl-tRNA aminoacylation-IBA21873635  
GO:0006429leucyl-tRNA aminoacylation-IDA10684970  
GO:0032543mitochondrial translation-IBA21873635  
GO:0106074aminoacyl-tRNA metabolism involved in translational fidelity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379724tRNA AminoacylationTAS
R-HSA-379726Mitochondrial tRNA aminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29762635An Epigenome-Wide Association Study (EWAS) of Obesity-Related Traits. (2018 May 14)Dhana KAm J Epidemiol