Gene: PPWD1

23398
-
peptidylprolyl isomerase domain and WD repeat containing 1
protein-coding
5q12.3
Ensembl:ENSG00000113593 Vega:OTTHUMG00000131226 UniprotKB:Q96BP3
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
1.794e-1 (AD)  5.774e-1 (ND)   (Frontal_Cortex)
4.266e-2 (AD)  6.025e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HARS20.911
RBM50.91
WDR750.908
EIF2B10.907
U2SURP0.906
SRSF110.905
NHLRC30.904
PDCD6IP0.904
ARGLU10.902
ATG140.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.608
OR4F29-0.561
MTRNR2L9-0.273
MTRNR2L6-0.271
KLRC2-0.254
MTRNR2L10-0.247
OR4F16-0.207
C8orf74-0.206
NKX6-1-0.198
TTLL10-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPWD1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PPWD1 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PPWD1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPWD1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PPWD1 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PPWD1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of PPWD1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PPWD1 mRNA25181051
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PPWD1 mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of PPWD1 mRNA28302478
D004147DioxinsDioxins affects the expression of PPWD1 mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PPWD1 mRNA22079256
D007854LeadLead affects the expression of PPWD1 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of PPWD1 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PPWD1 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPWD1 mRNA17961207
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPWD1 mRNA23649840
C568376MT19c compoundMT19c compound results in increased expression of PPWD1 mRNA21781307
C025256nonylphenolnonylphenol results in increased expression of PPWD1 mRNA22982499
C005290oxybenzoneoxybenzone results in increased expression of PPWD1 mRNA22721600
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PPWD1 mRNA27153767
C006253pirinixic acidpirinixic acid results in increased expression of PPWD1 mRNA18301758|2131816
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of PPWD1 mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of PPWD1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PPWD1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PPWD1 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of PPWD1 mRNA22238285
D011794QuercetinQuercetin results in decreased expression of PPWD1 mRNA21632981
C017947sodium arsenitesodium arsenite results in decreased expression of PPWD1 mRNA22714537
D053260SootSoot results in increased expression of PPWD1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PPWD1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPWD1 mRNA19465110
D014635Valproic AcidValproic Acid affects the expression of PPWD1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PPWD1 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of PPWD1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PPWD1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PPWD1 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IBA21873635  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IDA20676357  
GO:0016018cyclosporin A binding-IDA20676357  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0000413protein peptidyl-prolyl isomerization-IBA21873635  
GO:0000413protein peptidyl-prolyl isomerization-IDA20676357  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0016604nuclear body-IDA-  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol