Gene: DICER1

23405
DCR1|Dicer|Dicer1e|HERNA|K12H4.8-LIKE|MNG1|RMSE2
dicer 1, ribonuclease III
protein-coding
14q32.13
Ensembl:ENSG00000100697 MIM:606241 Vega:OTTHUMG00000166134 UniprotKB:Q9UPY3
NG_016311.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.055e-1 (AD)  2.875e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM100.878
ARAP20.865
DIP2B0.856
FRYL0.856
PRPF40A0.855
ANKIB10.854
ELF20.851
PHF30.846
VPS540.846
MAP4K50.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.495
OR4F5-0.492
SHISA8-0.263
PRTN3-0.257
HES5-0.242
CHRNA2-0.242
STON1-GTF2A1L-0.24
GOLGA6L1-0.227
ARSF-0.211
SLC29A4-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DICER1 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of DICER1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DICER1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DICER1 mRNA19770486
D001151ArsenicArsenic affects the methylation of DICER1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DICER1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DICER1 mRNA"19150397|2001819
D004958EstradiolEstradiol results in decreased expression of DICER1 mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of DICER1 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of DICER1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DICER1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DICER1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of DICER1 mRNA26079696
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D020148Butyric Acid"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
C059041calyculin Acalyculin A results in decreased expression of DICER1 mRNA25270620
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DICER1 gene20938992
C031180chrysenechrysene results in increased expression of DICER1 mRNA26377693
D007464Clioquinol[Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein22415087
C018021cobaltous chloridecobaltous chloride results in decreased expression of DICER1 mRNA25351418
C018021cobaltous chloridecobaltous chloride results in decreased expression of DICER1 protein25351418
C018021cobaltous chlorideEZH2 mRNA promotes the reaction [cobaltous chloride deficiency results in decreased expression of DICER1 mRNA]25351418
D003042CocaineCocaine results in increased expression of DICER1 mRNA23226419
D019327Copper SulfateCopper Sulfate results in decreased expression of DICER1 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of DICER1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DICER1 mRNA21632981
D003676DeferoxamineDeferoxamine results in decreased expression of DICER1 mRNA25351418
D003676DeferoxamineDeferoxamine results in decreased expression of DICER1 protein25351418
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DICER1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DICER1 mRNA17361019
D002945CisplatinCisplatin results in decreased expression of DICER1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of DICER1 protein21274007
D002945Cisplatin[Cisplatin results in increased expression of DICER1 protein] which results in increased metabolism of MIR63021274007
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein modified form binds to DICER1 promoter]21274007
D002945Cisplatin[Cisplatin results in increased phosphorylation of TP63 protein alternative form] promotes the reaction [TP63 protein modified form results in increased expression of DICER1 mRNA]21274007
D002945CisplatinDICER1 mutant form inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]25940438
D002945CisplatinDICER1 mutant form inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]25940438
D002945CisplatinDICER1 mutant form inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]25940438
D002945CisplatinDICER1 protein results in increased susceptibility to Cisplatin21274007
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DICER1 mRNA26924002
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D0151279,10-Dimethyl-1,2-benzanthracene"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
C024629dimethyl phthalatedimethyl phthalate affects the expression of DICER1 mRNA26924002
D004147DioxinsDioxins affects the expression of DICER1 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DICER1 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DICER1 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DICER1 exon17156454
D005472FluorouracilFluorouracil results in decreased expression of DICER1 mRNA16510598
D005485FlutamideFlutamide results in decreased expression of DICER1 mRNA21126777
D005485FlutamideFlutamide results in increased expression of DICER1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DICER1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of DICER1 mRNA23649840
C586265GSK343GSK343 results in increased expression of DICER1 mRNA25351418
C000593030GSK-J4GSK-J4 results in decreased expression of DICER1 mRNA25351418
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D005937Glucaric Acid"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DICER1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of DICER1 mRNA27392435
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of DICER1 mRNA19187980
D008627Mercuric ChlorideMercuric Chloride affects the expression of DICER1 mRNA20353558
D008694MethamphetamineMethamphetamine results in increased methylation of DICER1 promoter26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DICER1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DICER1 mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DICER1 mRNA26924002
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of DICER1 mRNA19187980
C022838nickel chloridenickel chloride results in decreased expression of DICER1 mRNA17312168
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DICER1 mRNA"12756304
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DICER1 mRNA25729387
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in decreased cleavage of MIR200A mRNA]25351418
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in decreased cleavage of MIR200B mRNA]25351418
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in decreased cleavage of MIR429 mRNA]25351418
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in decreased expression of CDH1 mRNA]25351418
D010100OxygenDICER1 protein inhibits the reaction [Oxygen deficiency results in increased expression of ZEB1 mRNA]25351418
D010100OxygenOxygen deficiency promotes the reaction [EZH2 protein binds to DICER1 promoter]25351418
D010100OxygenOxygen deficiency promotes the reaction [KDM6A protein binds to DICER1 promoter]25351418
D010100OxygenOxygen deficiency promotes the reaction [KDM6B protein binds to DICER1 promoter]25351418
D010100OxygenOxygen deficiency results in decreased expression of DICER1 mRNA25351418
D010100OxygenOxygen deficiency results in decreased expression of DICER1 protein25351418
D052638Particulate MatterParticulate Matter results in decreased expression of DICER1 mRNA15046786
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DICER1 mRNA27153767
D010795Phthalic AcidsPhthalic Acids results in increased expression of DICER1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DICER1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of DICER1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of DICER1 mRNA20852728
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of DICER1 mRNA16497877
D012643SeleniumSelenium results in decreased expression of DICER1 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of DICER1 mRNA24431212
D053260SootDICER1 gene SNP affects the susceptibility to Soot20211803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DICER1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DICER1 mRNA25613284
D013792ThalidomideThalidomide results in increased expression of DICER1 mRNA28892372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DICER1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DICER1 mRNA25729387
D014415TunicamycinTunicamycin results in decreased expression of DICER1 mRNA17127020
D014520UrethaneUrethane results in decreased expression of DICER1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DICER1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DICER1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of DICER1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DICER1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of DICER1 mRNA15046786
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DICER1 gene25560391
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 mRNA]"24792773
D009536Niacinamide"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DICER1 protein]"24792773
D014810Vitamin EVitamin E results in decreased expression of DICER1 mRNA19244175
C016837zinc chloride[Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein22415087
D019287Zinc SulfateZinc Sulfate results in increased expression of DICER1 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-IDA12411504  
GO:0003725double-stranded RNA binding-IMP19701182  
GO:0004386helicase activity-IEA-  
GO:0004521endoribonuclease activity-IDA25549615  
GO:0004521endoribonuclease activity-IMP18325616  19701182  
GO:0004521endoribonuclease activity-TAS19820710  
GO:0004525ribonuclease III activity-EXP11201747  11452083  12411504  12411505  
GO:0004525ribonuclease III activity-IBA21873635  
GO:0004525ribonuclease III activity-IDA21753850  
GO:0004530deoxyribonuclease I activity-IBA21873635  
GO:0005515protein binding-IPI12526743  14749716  15973356  16142218  16424907  17452327  
17507929  17531811  17932509  18325616  19716330  19804757  
19820710  20869963  21903422  23622242  23661684  23741051  
25446899  25557550  26496610  
GO:0005524ATP binding-IEA-  
GO:0019904protein domain specific binding-IPI12526743  
GO:0035197siRNA binding-IDA15973356  
GO:0046872metal ion binding-IEA-  
GO:0070883pre-miRNA binding-IDA18508075  25549615  
GO:0070883pre-miRNA bindingcontributes_toIDA18178619  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0006309apoptotic DNA fragmentation-IBA21873635  
GO:0010586miRNA metabolic process-TAS-  
GO:0010626negative regulation of Schwann cell proliferation-ISS-  
GO:0014040positive regulation of Schwann cell differentiation-ISS-  
GO:0021675nerve development-ISS-  
GO:0030422production of siRNA involved in RNA interference-IBA21873635  
GO:0030422production of siRNA involved in RNA interference-IDA15973356  17452327  23661684  
GO:0030422production of siRNA involved in RNA interference-TAS-  
GO:0030423targeting of mRNA for destruction involved in RNA interference-IMP15973356  17452327  
GO:0031054pre-miRNA processing-IBA21873635  
GO:0031054pre-miRNA processing-IDA15973356  16357216  18178619  23661684  25549615  
GO:0031643positive regulation of myelination-ISS-  
GO:0032290peripheral nervous system myelin formation-ISS-  
GO:0033168conversion of ds siRNA to ss siRNA involved in RNA interference-IMP19701182  
GO:0035087siRNA loading onto RISC involved in RNA interference-IDA15973356  
GO:0035196production of miRNAs involved in gene silencing by miRNA-IDA15973356  23661684  
GO:0035196production of miRNAs involved in gene silencing by miRNA-ISS-  
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA-IDA18178619  
GO:0036404conversion of ds siRNA to ss siRNA-IMP18325616  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0090501RNA phosphodiester bond hydrolysis-IBA21873635  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IDA21753850  25549615  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEA-  
GO:0005829cytosol-TAS-  
GO:0016442RISC complex-IBA21873635  
GO:0016442RISC complexNOTIDA16357216  
GO:0030425dendrite-IEA-  
GO:0030426growth cone-IEA-  
GO:0033167ARC complex-IC19701182  
GO:0035068micro-ribonucleoprotein complex-IDA17531811  
GO:0070062extracellular exosome-IDA28159509  
GO:0070578RISC-loading complex-IDA15973356  16357216  17531811  18178619  19820710  23661684  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-203927MicroRNA (miRNA) biogenesisTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-426486Small interfering RNA (siRNA) biogenesisTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27539334[Association between genetic variants in microRNA biosynthesis genes and the risk of head and neck squamous cell carcinoma]. (2016 Aug 10)Yuan WWZhonghua Liu Xing Bing Xue Za Zhi
28147216An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies. (2016 Dec)Mao XDiscov Med
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol