Gene: SIRT5

23408
SIR2L5
sirtuin 5
protein-coding
6p23
Ensembl:ENSG00000124523 MIM:604483 Vega:OTTHUMG00000014278 UniprotKB:Q9NXA8
NC_000006.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.894e-1 (AD)  5.359e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMIGO10.942
DZIP30.941
GRAMD1B0.939
MAPT0.937
MYH100.935
GRIA20.935
NUDCD30.935
TMEM250.934
CLCN60.934
ANK20.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.551
OR4F5-0.541
OR4F29-0.503
C9orf135-0.491
KLRB1-0.489
IL18RAP-0.474
WWTR1-0.471
KIAA0040-0.469
KCNJ15-0.468
BEST3-0.468

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SIRT5 mRNA"21346803
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to SIRT5 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SIRT5 protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of SIRT5 mRNA17562736
D000393Air PollutantsAir Pollutants results in decreased expression of SIRT5 mRNA25056781
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SIRT5 protein]26598702
D001280AtrazineAtrazine results in decreased expression of SIRT5 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIRT5 mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SIRT5 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SIRT5 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SIRT5 mRNA21839799
D004958EstradiolEstradiol affects the expression of SIRT5 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of SIRT5 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SIRT5 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of SIRT5 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of SIRT5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SIRT5 gene28505145
D002065BuspironeBuspirone results in decreased expression of SIRT5 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of SIRT5 mRNA26079696
D002995Clofibric AcidClofibric Acid affects the expression of SIRT5 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SIRT5 mRNA24612858
D019327Copper SulfateCopper Sulfate results in decreased expression of SIRT5 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of SIRT5 mRNA27281708
D016572CyclosporineCyclosporine results in decreased expression of SIRT5 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SIRT5 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SIRT5 mRNA21266533
D004178DiquatDiquat affects the expression of SIRT5 mRNA22814884
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SIRT5 mRNA17557909
D007213IndomethacinIndomethacin results in increased expression of SIRT5 mRNA28201806
C544151jinfukangjinfukang results in increased expression of SIRT5 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of SIRT5 mRNA16807920
D008628MercuryMercury analog results in decreased expression of SIRT5 mRNA25056781
D008687MetforminMetformin results in decreased expression of SIRT5 protein24687991
D008694MethamphetamineMethamphetamine results in decreased expression of SIRT5 mRNA25452209
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SIRT5 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SIRT5 mRNA"25620056
D010416PentachlorophenolPentachlorophenol results in decreased expression of SIRT5 mRNA23892564
C046012pentanalpentanal results in decreased expression of SIRT5 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SIRT5 mRNA23602845
C006253pirinixic acidpirinixic acid results in increased expression of SIRT5 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of SIRT5 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of SIRT5 protein23718831
C059514resveratrolSIRT5 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]22585829
C059514resveratrolSIRT5 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]22585829
C059514resveratrolresveratrol results in decreased expression of SIRT5 mRNA23525482
D012715Sesame OilSesame Oil results in increased expression of SIRT5 mRNA29191790
D012834SilverSilver results in decreased expression of SIRT5 mRNA26551752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIRT5 mRNA21570461
D013893ThiramThiram results in decreased expression of SIRT5 mRNA20530235
C011559tributyltintributyltin results in decreased expression of SIRT5 mRNA29191790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SIRT5 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of SIRT5 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of SIRT5 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of SIRT5 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of SIRT5 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activityNOTTAS17456799  
GO:0008270zinc ion binding-IDA22076378  
GO:0034979NAD-dependent protein deacetylase activity-TAS-  
GO:0036054protein-malonyllysine demalonylase activity-IDA21908771  22076378  24703693  
GO:0036055protein-succinyllysine desuccinylase activity-IDA21908771  22076378  24140062  24703693  29180469  
GO:0061697protein-glutaryllysine deglutarylase activity-IDA24703693  
GO:0070403NAD+ binding-IDA21908771  22076378  
GO ID GO Term Qualifier Evidence PubMed
GO:0006342chromatin silencing-TAS10381378  
GO:0006471protein ADP-ribosylationNOTTAS17456799  
GO:0006476protein deacetylation-IDA18680753  
GO:0006476protein deacetylationNOTIDA22076378  
GO:0007005mitochondrion organization-TAS-  
GO:0010566regulation of ketone biosynthetic process-ISS-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0036046protein demalonylation-IDA24703693  
GO:0036047peptidyl-lysine demalonylation-IDA21908771  22076378  
GO:0036048protein desuccinylation-IDA24140062  24703693  29180469  
GO:0036049peptidyl-lysine desuccinylation-IDA21908771  22076378  
GO:0061698protein deglutarylation-IDA24703693  
GO:0061699peptidyl-lysine deglutarylation-IEA-  
GO:2000378negative regulation of reactive oxygen species metabolic process-IDA24140062  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS23806337  
GO:0005739mitochondrion-IDA16079181  23806337  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005758mitochondrial intermembrane space-IDA18680753  
GO:0005759mitochondrial matrix-IDA18680753  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA23806337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22087257Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011)Dong CPLoS One
25541994SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. (2014)TenNapel MJPLoS One
25981116SIRT5 prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3. (2015 Sep)Wang YCell Stress Chaperones