Gene: SIRT4

23409
SIR2L4
sirtuin 4
protein-coding
12q24.23-q24.31
Ensembl:ENSG00000089163 MIM:604482 Vega:OTTHUMG00000169028 UniprotKB:Q9Y6E7
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.063e-1 (AD)  4.850e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCGF10.83
CCNF0.825
TMEM810.816
DEDD20.81
SH3BP5L0.806
PPID0.805
NUDT90.803
TIMM220.801
SSTR30.8
HTR1E0.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TIGIT-0.487
MBNL3-0.46
TFPI2-0.46
NSUN7-0.451
LRRCC1-0.45
KLRB1-0.449
ASB4-0.448
RGS22-0.437
MYOM1-0.434
REST-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SIRT4 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SIRT4 mRNA16788091
D000082AcetaminophenAcetaminophen results in increased expression of SIRT4 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of SIRT4 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of SIRT4 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SIRT4 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of SIRT4 mRNA26377693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SIRT4 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of SIRT4 promoter27415467
C006780bisphenol Abisphenol A results in increased methylation of SIRT4 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of SIRT4 mRNA26079696
D002994ClofibrateClofibrate results in decreased expression of SIRT4 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of SIRT4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SIRT4 mRNA20106945
C014347decitabinedecitabine affects the expression of SIRT4 mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SIRT4 mRNA28628672
D002945CisplatinCisplatin affects the expression of SIRT4 mRNA23300844
D002945CisplatinCisplatin results in increased expression of SIRT4 mRNA27392435
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SIRT4 mRNA20064776
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of SIRT4 promoter27415467
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SIRT4 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SIRT4 mRNA23649840
D005947GlucoseGlucose affects the expression of SIRT4 protein24349266
D005947GlucoseGlucose results in decreased expression of SIRT4 mRNA24349266
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SIRT4 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SIRT4 mRNA24349266
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SIRT4 protein24349266
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SIRT4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SIRT4 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of SIRT4 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SIRT4 mRNA24136188
D008687MetforminMetformin results in increased expression of SIRT4 mRNA24687991
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SIRT4 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SIRT4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SIRT4 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SIRT4 mRNA"25554681
D009525NiacinNiacin deficiency results in increased expression of SIRT4 mRNA22860104
D019301Oleic AcidOleic Acid results in decreased expression of SIRT4 mRNA24349266
D017382Reactive Oxygen SpeciesSIRT4 promotes the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]27099261
D017382Reactive Oxygen Species[SIRT4 results in increased acetylation of and results in decreased activity of SOD2 protein] promotes the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]27099261
C059514resveratrolresveratrol results in decreased expression of SIRT4 mRNA23525482
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SIRT4 mRNA25895662
D026082Singlet OxygenSinglet Oxygen results in increased expression of SIRT4 mRNA22860104
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog affects the localization of RELA protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased degradation of NFKBIA protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased expression of SELE mRNA]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased expression of SELE protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased expression of VCAM1 mRNA]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased expression of VCAM1 protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased secretion of IL1B protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased secretion of IL6 protein]24603126
D012906SmokeSIRT4 protein inhibits the reaction [Smoke analog results in increased secretion of TNF protein]24603126
D012906SmokeSmoke analog results in decreased expression of SIRT4 mRNA24603126
D012906SmokeSmoke analog results in decreased expression of SIRT4 protein24603126
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SIRT4 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of SIRT4 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of SIRT4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SIRT4 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of SIRT4 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003950NAD+ ADP-ribosyltransferase activity-IDA16959573  17715127  
GO:0003950NAD+ ADP-ribosyltransferase activity-TAS17456799  
GO:0005515protein binding-IPI16959573  17715127  25525879  
GO:0034979NAD-dependent protein deacetylase activityNOTIDA17715127  
GO:0046872metal ion binding-IEA-  
GO:0047708biotinidase activity-IDA25525879  
GO:0061690lipoamidase activity-IDA25525879  
GO:0070403NAD+ binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000820regulation of glutamine family amino acid metabolic process-IEA-  
GO:0006342chromatin silencing-TAS10381378  
GO:0006471protein ADP-ribosylation-ISS-  
GO:0006471protein ADP-ribosylation-TAS17456799  
GO:0006541glutamine metabolic process-ISS-  
GO:0006974cellular response to DNA damage stimulus-ISS-  
GO:0007005mitochondrion organization-TAS-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0034983peptidyl-lysine deacetylation-ISS-  
GO:0046322negative regulation of fatty acid oxidation-IMP24043310  
GO:0046322negative regulation of fatty acid oxidation-ISS-  
GO:0046676negative regulation of insulin secretion-IMP17715127  
GO:0046889positive regulation of lipid biosynthetic process-ISS-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0072350tricarboxylic acid metabolic process-ISS-  
GO:1903217negative regulation of protein processing involved in protein targeting to mitochondrion-IEA-  
GO:1904182regulation of pyruvate dehydrogenase activity-IDA25525879  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA16079181  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005759mitochondrial matrix-IDA16959573  17715127  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24603126SIRT4 inhibits cigarette smoke extracts-induced mononuclear cell adhesion to human pulmonary microvascular endothelial cells via regulating NF-kappaB activity. (2014 May 2)Chen YToxicol Lett