Gene info: ID 23410

Gene: SIRT3

GENE ID: 23410

Synonyms: SIR2L3

Description: sirtuin 3

Gene type: protein-coding

Location: 11p15.5

dbXrefs: Ensembl:ENSG00000142082 MIM:604481 Vega:OTTHUMG00000119074 UniprotKB:Q9NTG7

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.044e-1 (AD) 6.056e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
USP20	0.951
P4HTM	0.942
MICU1	0.94
DGCR2	0.938
ERAL1	0.938
URGCP	0.938
RXRB	0.937
NDUFA10	0.937
KLHL22	0.936
ATG9A	0.934

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.627
OR4F29	-0.581
TFPI2	-0.466
KLRB1	-0.458
RAI14	-0.425
TBX21	-0.422
MTRNR2L6	-0.42
C9orf153	-0.42
PABPC4L	-0.414
KCNJ15	-0.412

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C044755	1-methyl-4-phenyl-2,3-dihydropyridinium	"1-methyl-4-phenyl-2,3-dihydropyridinium results in decreased expression of SIRT3 mRNA"	21856379
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of SIRT3 mRNA"	25575267
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SIRT3 mRNA"	21346803
C097869	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein]"	23886954
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in decreased expression of SIRT3 mRNA"	25575267
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein	21449565
D000082	Acetaminophen	Acetaminophen affects the expression of SIRT3 mRNA	17562736
D000244	Adenosine Diphosphate	SIRT3 protein results in decreased abundance of Adenosine Diphosphate	23166782
D000255	Adenosine Triphosphate	SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]	23166782
D001280	Atrazine	Atrazine affects the expression of SIRT3 mRNA	27114639
D001280	Atrazine	Atrazine results in decreased expression of SIRT3 mRNA	27114639
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SIRT3 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SIRT3 mRNA	22228805
D001599	Berberine	[Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein	26712469
D001599	Berberine	Berberine results in decreased expression of SIRT3 mRNA	26712469
D001599	Berberine	Berberine results in decreased expression of SIRT3 protein	26712469
D001599	Berberine	Berberine results in increased expression of SIRT3 mRNA	27311644
D004958	Estradiol	Estradiol results in decreased expression of SIRT3 mRNA	25575267
C006780	bisphenol A	bisphenol A affects the expression of SIRT3 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of SIRT3 mRNA	25575267
C006780	bisphenol A	bisphenol A results in increased methylation of SIRT3 promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of SIRT3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SIRT3 gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SIRT3 mRNA	23166782
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of SIRT3 mRNA	26520405
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of SIRT3 protein	26520405
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of SIRT3 protein	27923775
D020122	tert-Butylhydroperoxide	SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]]	25522270
D020122	tert-Butylhydroperoxide	SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]]	25522270
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SIRT3 mRNA	27339419
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIRT3 gene	20938992
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SIRT3 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]	28698153
D003474	Curcumin	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]	28951138
D003474	Curcumin	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]	28951138
D013759	Dronabinol	Dronabinol results in decreased expression of SIRT3 mRNA	12237329
D003976	Diazinon	Diazinon results in increased methylation of SIRT3 gene	22964155
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SIRT3 mRNA	21266533
D003997	Dicarbethoxydihydrocollidine	Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA	18098314
D002945	Cisplatin	SIRT3 protein results in decreased susceptibility to Cisplatin	21472714
D002945	Cisplatin	Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein	28698153
D002945	Cisplatin	Curcumin inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein]	28698153
D018119	Stavudine	Stavudine results in increased expression of SIRT3 protein	27041070
D004041	Dietary Fats	Dietary Fats results in increased expression of SIRT3 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in decreased expression of SIRT3 mRNA	22327056
D004041	Dietary Fats	Dietary Fats results in decreased expression of SIRT3 protein	25686565
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]	25686565
D004041	Dietary Fats	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]	22327056
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of SIRT3 mRNA	25575267
D004147	Dioxins	Dioxins affects the expression of SIRT3 mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in decreased expression of SIRT3 protein	26678157
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of SIRT3 mRNA	29175576
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of SIRT3 protein	29175576
D004964	Estriol	Estriol results in decreased expression of SIRT3 mRNA	25575267
D000431	Ethanol	Ethanol results in increased metabolism of SIRT3 protein	21449565
D000431	Ethanol	Ethanol results in increased expression of SIRT3 mRNA	18793633
D000431	Ethanol	resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT3 mRNA]	18793633
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SIRT3 mRNA	17557909
D005485	Flutamide	Flutamide results in decreased expression of SIRT3 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIRT3 gene	20938992
D005947	Glucose	Glucose deficiency results in increased expression of SIRT3 protein	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [Glucose results in increased acetylation of FOXO1 protein]	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [Glucose results in increased expression of CAT protein]	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [Glucose results in increased expression of CDKN2A protein alternative form]	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [Glucose results in increased expression of GLB1 protein]	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [Glucose results in increased expression of SOD2 protein]	23494737
D005947	Glucose	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]	25979314
C529376	GYY 4137	GYY 4137 inhibits the reaction [AGT protein results in decreased expression of SIRT3 protein]	28503736
C529376	GYY 4137	SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]]	28503736
C529376	GYY 4137	SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]]	28503736
C529376	GYY 4137	SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]]	28503736
C529376	GYY 4137	SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]]	28503736
C529376	GYY 4137	SIRT3 protein affects the reaction [GYY 4137 inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]	28503736
D006854	Hydrocortisone	SIRT3 protein results in increased secretion of Hydrocortisone	22585829
C544151	jinfukang	jinfukang results in increased expression of SIRT3 mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of SIRT3 protein	27236077
C008261	lead acetate	PPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein]	27236077
D008070	Lipopolysaccharides	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]	28951138
D008070	Lipopolysaccharides	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]	28951138
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA	28951138
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein	28951138
C013099	mancozeb	mancozeb results in decreased activity of SIRT3 protein	21251949
D008344	Maneb	Maneb results in decreased activity of SIRT3 protein	21251949
D008687	Metformin	Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]	23166782
D008687	Metformin	Metformin results in decreased expression of SIRT3 mRNA	23166782\|2468799
D008687	Metformin	Metformin results in decreased expression of SIRT3 protein	23166782
D008687	Metformin	SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]	23166782
D008687	Metformin	SIRT3 protein results in decreased susceptibility to Metformin	23166782
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SIRT3 gene	20938992
D008727	Methotrexate	Methotrexate affects the expression of SIRT3 mRNA	18502557
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of SIRT3 mRNA	25543134
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SIRT3 mRNA"	25554681
D000068577	Nebivolol	"3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein]"	23886954
D000068577	Nebivolol	Nebivolol results in increased expression of SIRT3 protein	23886954
D000073878	Palm Oil	Palm Oil results in increased expression of SIRT3 mRNA	18042831
D052638	Particulate Matter	Particulate Matter results in decreased expression of and results in decreased activity of SIRT3 protein	27125970
D052638	Particulate Matter	Particulate Matter results in decreased expression of SIRT3 mRNA	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in decreased activity of CAT protein]	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in decreased activity of SOD2 protein]	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in increased abundance of Reactive Oxygen Species]	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in increased expression of CXCL8 protein]	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]	27125970
D052638	Particulate Matter	SIRT3 protein inhibits the reaction [Particulate Matter results in increased expression of TNF protein]	27125970
C008971	polymarcine	polymarcine results in decreased activity of SIRT3 protein	21251949
C045950	propiconazole	propiconazole results in decreased expression of SIRT3 mRNA	21278054
D017382	Reactive Oxygen Species	SIRT3 protein inhibits the reaction [Particulate Matter results in increased abundance of Reactive Oxygen Species]	27125970
C059514	resveratrol	PPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 mRNA]	25522270
C059514	resveratrol	PPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 protein]	25522270
C059514	resveratrol	resveratrol affects the localization of and results in increased expression of SIRT3 protein	25522270
C059514	resveratrol	resveratrol results in decreased expression of SIRT3 mRNA	21980390
C059514	resveratrol	resveratrol results in increased activity of SIRT3 protein	24178296
C059514	resveratrol	resveratrol results in increased expression of SIRT3 mRNA	25522270
C059514	resveratrol	SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of and results in increased acetylation of SOD2 protein]]	25522270
C059514	resveratrol	SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]]	25522270
C059514	resveratrol	SIRT3 protein affects the reaction [resveratrol results in decreased acetylation of CYP11A1 protein]	22585829
C059514	resveratrol	SIRT3 protein affects the reaction [resveratrol results in increased expression of CYP11A1 protein]	22585829
C059514	resveratrol	resveratrol results in decreased expression of SIRT3 mRNA	23525482
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]	25686565
C059514	resveratrol	resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT3 mRNA]	18793633
D012402	Rotenone	SIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]	27053302
C568740	salvianolic acid	salvianolic acid results in increased expression of SIRT3	23993977
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of PPARGC1A protein]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of SOD2 protein]	25979314
C017947	sodium arsenite	SIRT3 protein inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of and results in decreased activity of FOXO3 protein]	25979314
C017947	sodium arsenite	sodium arsenite inhibits the reaction [FOXO3 protein binds to SIRT3 protein]	25979314
C017947	sodium arsenite	sodium arsenite results in decreased expression of SIRT3 protein	25979314
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in decreased expression of FOXO3 protein]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in decreased expression of SOD2 protein]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of MYH7 protein]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPA protein]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]]	28503736
C025451	sodium bisulfide	SIRT3 protein affects the reaction [sodium bisulfide inhibits the reaction [AGT protein results in increased expression of NPPB protein]]	28503736
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [AGT protein results in decreased expression of SIRT3 mRNA]	28503736
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [AGT protein results in decreased expression of SIRT3 protein]	28503736
D012999	Soman	Soman results in decreased expression of SIRT3 mRNA	19281266
D000068698	Tenofovir	Tenofovir results in increased expression of SIRT3 protein	27041070
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SIRT3 mRNA	28011154
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SIRT3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA	21724226
D019284	Thapsigargin	Thapsigargin results in decreased expression of SIRT3 mRNA	22378314
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]	22327056
D008063	Thioctic Acid	[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein	22327056
D008063	Thioctic Acid	[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein	22327056
D008063	Thioctic Acid	Thioctic Acid results in increased expression of SIRT3 protein	22327056
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA]	28951138
D014028	Tobacco Smoke Pollution	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein]	28951138
D014028	Tobacco Smoke Pollution	[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA	28951138
D014028	Tobacco Smoke Pollution	[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 protein	28951138
D014415	Tunicamycin	Tunicamycin results in decreased expression of SIRT3 mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of SIRT3 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of SIRT3 mRNA	24136188
D014635	Valproic Acid	Valproic Acid results in decreased methylation of SIRT3 gene	29154799
D014640	Vancomycin	Vancomycin results in increased expression of SIRT3 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SIRT3 gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of SIRT3 mRNA	26682919
D009536	Niacinamide	[Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein	26712469
D015215	Zidovudine	Zidovudine results in increased expression of SIRT3 protein	27041070
D015034	Zinc Oxide	Zinc Oxide affects the expression of SIRT3 mRNA	28648595

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003950	NAD+ ADP-ribosyltransferase activity	NOT	TAS	17456799
GO:0005515	protein binding	-	IPI	16788062 19343720 19535340 22770219 23283301 24344202 29445193
GO:0008270	zinc ion binding	-	IDA	19535340
GO:0017136	NAD-dependent histone deacetylase activity	-	IEA	-
GO:0019899	enzyme binding	-	IEA	-
GO:0034979	NAD-dependent protein deacetylase activity	-	TAS	-
GO:0043565	sequence-specific DNA binding	-	IDA	29445193
GO:0070403	NAD+ binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006471	protein ADP-ribosylation	NOT	TAS	17456799
GO:0006476	protein deacetylation	-	IDA	16788062
GO:0007005	mitochondrion organization	-	TAS	-
GO:0007568	aging	-	IEA	-
GO:0009060	aerobic respiration	-	IMP	22309213
GO:0016575	histone deacetylation	-	IEA	-
GO:0032024	positive regulation of insulin secretion	-	IEA	-
GO:0034983	peptidyl-lysine deacetylation	-	IMP	22309213
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:2000378	negative regulation of reactive oxygen species metabolic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IDA	16079181
GO:0005759	mitochondrial matrix	-	IDA	29445193
GO:0005759	mitochondrial matrix	-	TAS	-
GO:0032991	protein-containing complex	-	IDA	23283301 29445193

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1592230	Mitochondrial biogenesis	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22087257	Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011)	Dong C	PLoS One
25541994	SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. (2014)	TenNapel MJ	PLoS One
25757953	Sirt3-MnSOD axis represses nicotine-induced mitochondrial oxidative stress and mtDNA damage in osteoblasts. (2015 Apr)	Li Y	Acta Biochim Biophys Sin (Shanghai)