| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ZNF24 | 0.888 |
| STAG2 | 0.87 |
| USP1 | 0.848 |
| PAK2 | 0.848 |
| GABPA | 0.846 |
| SMC3 | 0.845 |
| ANKIB1 | 0.843 |
| KTN1 | 0.843 |
| TWF1 | 0.843 |
| VPS54 | 0.837 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F29 | -0.54 |
| OR4F5 | -0.524 |
| ADRA1D | -0.284 |
| CRYBA2 | -0.279 |
| GSG1 | -0.278 |
| CRH | -0.27 |
| PHOSPHO1 | -0.267 |
| KCNG2 | -0.266 |
| VGF | -0.256 |
| NKX6-3 | -0.253 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB05073 | SRT501 | Small Molecule | - | Investigational | Target |
| DB13978 | Selisistat | Small Molecule | 49843-98-3 | Experimental | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C573921 | 10-(2-(5H-(1,2,4)triazino(5,6-b)indol-3-ylthio)butanoyl)-10H-phenothiazine | "10-(2-(5H-(1,2,4)triazino(5,6-b)indol-3-ylthio)butanoyl)-10H-phenothiazine results in decreased activity of SIRT1 protein" | 24296261 |
| C435044 | 1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol | 1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein] | 22936809 |
| C031763 | 1,3-butadiene | "1,3-butadiene results in increased expression of SIRT1 mRNA" | 25237060 |
| C532162 | 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine | "[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of SIRT1 mRNA" | 20453058 |
| C032904 | 2,2',3,5',6-pentachlorobiphenyl | "SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]]" | 26307266 |
| C032904 | 2,2',3,5',6-pentachlorobiphenyl | "SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]]" | 26307266 |
| C032904 | 2,2',3,5',6-pentachlorobiphenyl | "SIRT1 protein results in decreased susceptibility to 2,2',3,5',6-pentachlorobiphenyl" | 26307266 |
| C016403 | 2,4-dinitrotoluene | "2,4-dinitrotoluene affects the expression of SIRT1 mRNA" | 21346803 |
| C071738 | 2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate | [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the expression of SIRT1 protein | 24885036 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein" | 17327447|2224559 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "[3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein" | 22245592 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "[3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein" | 22245592 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "[3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein" | 22245592 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "[3,3',4,5'-tetrahydroxystilbene results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein" | 22245592 |
| C041525 | 3,3',4,5'-tetrahydroxystilbene | "3,3',4,5'-tetrahydroxystilbene results in increased expression of SIRT1 protein" | 22245592 |
| C434003 | 3-(4-methylphenylsulfonyl)-2-propenenitrile | 3-(4-methylphenylsulfonyl)-2-propenenitrile results in increased expression of SIRT1 mRNA | 21957481 |
| C015392 | 3-nitropropionic acid | 3-nitropropionic acid results in decreased expression of SIRT1 protein | 18538940 |
| C015392 | 3-nitropropionic acid | 3-nitropropionic acid results in decreased expression of SIRT1 protein | 18538940 |
| C090942 | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased expression of SIRT1 protein | 24894820 |
| C108123 | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine | "4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein]" | 22936809 |
| C027576 | 4-hydroxy-2-nonenal | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal] | 24633890 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with TNF protein] results in decreased expression of SIRT1 protein" | 24145604 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]" | 26271894 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of SIRT1]" | 24584901 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]" | 25943029 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[TNF protein co-treated with resveratrol] results in increased expression of SIRT1 protein]" | 24145604 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of SIRT1 protein" | 25943029 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]" | 24465016 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased expression of SIRT1 protein]" | 24465016 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of SIRT1 protein" | 24465016 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]" | 23211629 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased activity of SIRT1 protein" | 18482975 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "SIRT1 protein promotes the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]" | 18482975 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "SIRT1 protein promotes the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein]" | 18482975 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "SIRT1 protein promotes the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein]" | 18482975 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]" | 18482975 |
| C438505 | 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one | "STK11 protein promotes the reaction [[6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]" | 18482975 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Glucose co-treated with resveratrol] results in increased expression of SIRT1 protein]" | 24064760 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]]" | 25943029 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased activity of SIRT1 protein]" | 24603648|2584913 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SIRT1 mRNA]" | 23358928 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]" | 23358928 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]" | 21163946 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA]]" | 21163946 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]]" | 21163946 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of SLC2A2 mRNA]]" | 21163946 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]]" | 21163946 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Ethanol results in decreased expression of SIRT1 protein]" | 27989594 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]" | 25943029 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein" | 20426787|2116394 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP1 protein]" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA" | 22146233 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 mRNA" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP1 protein" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 mRNA" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 protein" | 20426787 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein" | 24726431 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]" | 24726431 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]" | 25665036|2645094 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol" | 23124026 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP1 protein" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased cleavage of and results in increased activity of CASP3 protein" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased localization of FOXO3 protein" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Glucose" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased localization of and results in decreased activity of SIRT1 protein" | 20370652 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein" | 22968147 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]" | 21212096 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]" | 21212096 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]" | 21212096 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]" | 21212096 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of MAFA mRNA" | 22968147 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased expression of NKX6-1 mRNA" | 22968147 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose" | 21212096 |
| C550547 | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein" | 21212096|2159318 |
| C053907 | 8-cyclopentyl-1,3-dimethylxanthine | "8-cyclopentyl-1,3-dimethylxanthine results in increased expression of SIRT1 protein" | 25943029 |
| C099958 | acanthoic acid | acanthoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 28964808 |
| D000082 | Acetaminophen | Acetaminophen results in increased expression of SIRT1 mRNA | 21420995|2906747 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of SIRT1 mRNA | 17562736 |
| D000082 | Acetaminophen | Acetaminophen inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 25956474 |
| D000082 | Acetaminophen | [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA | 17585979 |
| D000082 | Acetaminophen | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA] | 17585979 |
| C056165 | acetovanillone | acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] | 26930420 |
| D000109 | Acetylcholine | SIRT1 protein affects the susceptibility to Acetylcholine | 23422569 |
| D000255 | Adenosine Triphosphate | SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] | 16366736 |
| D000255 | Adenosine Triphosphate | SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein] | 16366736 |
| D000255 | Adenosine Triphosphate | [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] | 16366736 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased expression of SIRT1 mRNA | 19770486 |
| C031143 | AICA ribonucleotide | AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] | 27688165 |
| C031143 | AICA ribonucleotide | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| C031143 | AICA ribonucleotide | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide results in increased expression of SIRT1 protein]" | 24465016 |
| C031143 | AICA ribonucleotide | AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| C031143 | AICA ribonucleotide | AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 24465016 |
| C031143 | AICA ribonucleotide | AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein] | 22058332 |
| C031143 | AICA ribonucleotide | AICA ribonucleotide results in increased expression of SIRT1 protein | 24465016 |
| C031143 | AICA ribonucleotide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide | 25108154 |
| D000596 | Amino Acids | [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 27358235 |
| C553921 | amurensin G | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of CTNNB1] | 22245592 |
| C553921 | amurensin G | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of EGLN1 protein] | 22245592 |
| C553921 | amurensin G | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of MYC protein] | 22245592 |
| C553921 | amurensin G | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | 22245592 |
| C553921 | amurensin G | amurensin G results in decreased expression of SIRT1 protein | 22245592 |
| C553921 | amurensin G | amurensin G results in decreased activity of SIRT1 protein | 22245592 |
| C058317 | arsenic disulfide | arsenic disulfide results in decreased expression of SIRT1 protein | 18298901 |
| C058317 | arsenic disulfide | [arsenic disulfide results in decreased expression of SIRT1 protein] which results in increased expression of TP53 protein | 18298901 |
| C058317 | arsenic disulfide | SIRT1 protein results in decreased susceptibility to arsenic disulfide | 18298901 |
| C058317 | arsenic disulfide | wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] | 18298901 |
| C006632 | arsenic trioxide | arsenic trioxide results in decreased expression of SIRT1 mRNA | 19763917 |
| C015001 | arsenite | arsenite promotes the reaction [TP53 protein binds to SIRT1 promoter] | 25281835 |
| C015001 | arsenite | arsenite results in decreased expression of SIRT1 mRNA | 23744399 |
| C015001 | arsenite | arsenite results in increased expression of SIRT1 mRNA | 25281835 |
| C015001 | arsenite | arsenite results in increased expression of SIRT1 protein | 25281835 |
| C015001 | arsenite | arsenite results in increased methylation of SIRT1 promoter | 25281835 |
| C015001 | arsenite | Taurine inhibits the reaction [arsenite results in decreased expression of SIRT1 mRNA] | 23744399 |
| D017638 | Asbestos, Crocidolite | "Asbestos, Crocidolite results in increased expression of SIRT1 mRNA" | 18687144 |
| D001241 | Aspirin | Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D001241 | Aspirin | Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] | 19520256 |
| D001241 | Aspirin | Aspirin inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D001280 | Atrazine | Atrazine results in decreased expression of SIRT1 mRNA | 25929836 |
| D001280 | Atrazine | Atrazine results in decreased expression of SIRT1 mRNA | 27114639 |
| D001280 | Atrazine | Atrazine results in decreased expression of SIRT1 mRNA | 27114639 |
| C040929 | bafilomycin A1 | bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] | 24889822 |
| D001514 | Bee Venoms | [Lipopolysaccharides co-treated with Bee Venoms] affects the expression of SIRT1 mRNA | 25561937 |
| C037689 | benzamide | benzamide analog results in decreased activity of SIRT1 protein | 19616958 |
| D053119 | Benzophenanthridines | Benzophenanthridines analog results in decreased expression of SIRT1 mRNA | 23117580 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] | 25440059 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with SIRT1 protein] results in increased ubiquitination of and results in decreased acetylation of EP300 protein | 23297412 |
| C072553 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT1 protein results in decreased expression of EP300 protein] | 23297412 |
| D001599 | Berberine | [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein | 26712469 |
| D001599 | Berberine | Berberine results in decreased expression of SIRT1 mRNA | 26712469 |
| D001599 | Berberine | Berberine results in decreased expression of SIRT1 protein | 26712469 |
| D001599 | Berberine | SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein] | 26712469 |
| D004958 | Estradiol | Estradiol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]] | 24771768 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of SIRT1 mRNA | 21179406 |
| C006780 | bisphenol A | bisphenol A affects the expression of SIRT1 mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A results in increased expression of SIRT1 mRNA | 28765096 |
| C006780 | bisphenol A | bisphenol A affects the expression of SIRT1 mRNA | 21786754 |
| C006780 | bisphenol A | bisphenol A inhibits the reaction [SIRT1 protein binds to CAV1 protein] | 28067316 |
| C006780 | bisphenol A | bisphenol A results in increased expression of SIRT1 protein | 28067316 |
| D001761 | Bleomycin | Bleomycin results in decreased expression of SIRT1 mRNA | 25707573 |
| D001761 | Bleomycin | Bleomycin results in decreased expression of SIRT1 protein | 25707573 |
| D001761 | Bleomycin | resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 mRNA] | 25707573 |
| D001761 | Bleomycin | resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 protein] | 25707573 |
| D001786 | Blood Glucose | [Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein | 28477916 |
| D001786 | Blood Glucose | genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 28477916 |
| D001786 | Blood Glucose | sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 28477916 |
| D015124 | 8-Bromo Cyclic Adenosine Monophosphate | [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein | 16709600 |
| C040918 | butein | butein results in increased activity of SIRT1 protein | 17327447 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in decreased expression of SIRT1 mRNA | 26520405 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in decreased expression of SIRT1 protein | 26520405 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in decreased expression of SIRT1 mRNA | 27923775 |
| C027561 | butylbenzyl phthalate | butylbenzyl phthalate results in decreased expression of SIRT1 protein | 27923775 |
| D020122 | tert-Butylhydroperoxide | hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] | 18552516 |
| D020122 | tert-Butylhydroperoxide | tert-Butylhydroperoxide results in decreased expression of SIRT1 protein | 18552516 |
| D002104 | Cadmium | Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein | 25159133 |
| D002104 | Cadmium | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] | 25159133 |
| D002104 | Cadmium | Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein] | 25159133 |
| D002104 | Cadmium | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein | 25159133 |
| D019256 | Cadmium Chloride | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] | 25159133 |
| D019256 | Cadmium Chloride | Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein] | 25159133 |
| D019256 | Cadmium Chloride | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| D000001 | Calcimycin | SIRT1 protein affects the susceptibility to Calcimycin | 23422569 |
| D002166 | Camptothecin | "Camptothecin inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased expression of SIRT1 protein]" | 24726431 |
| D002166 | Camptothecin | Camptothecin results in decreased expression of SIRT1 protein | 24726431 |
| D002166 | Camptothecin | [SIRT1 mutant form co-treated with Camptothecin] results in increased acetylation of TP53 protein | 24726431 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in decreased expression of SIRT1 protein | 26435214 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride results in increased expression of SIRT1 protein | 28347707 |
| D002251 | Carbon Tetrachloride | Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] | 28347707 |
| D002251 | Carbon Tetrachloride | SIRT1 results in decreased susceptibility to Carbon Tetrachloride | 23993977 |
| C026678 | carboprostacyclin | carboprostacyclin results in increased expression of SIRT1 mRNA | 25339356 |
| C588229 | chikusetsusaponin V | chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] | 25073091 |
| D002719 | Chlormethiazole | Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24892905 |
| D002719 | Chlormethiazole | Chlormethiazole results in decreased expression of SIRT1 protein | 24892905 |
| D002784 | Cholesterol | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]" | 21212096 |
| D002784 | Cholesterol | [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA | 25833014 |
| D002784 | Cholesterol | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol] | 21212096 |
| D002784 | Cholesterol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] | 25833014 |
| C045645 | cilostazol | cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] | 19520256 |
| C045645 | cilostazol | cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] | 19520256 |
| C045645 | cilostazol | cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein] | 19520256 |
| C045645 | cilostazol | cilostazol results in increased expression of SIRT1 protein | 18556572 |
| C045645 | cilostazol | cilostazol affects the expression of and affects the activity of SIRT1 protein | 24254769 |
| C045645 | cilostazol | cilostazol affects the expression of SIRT1 mRNA | 24254769 |
| C045645 | cilostazol | cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein] | 24254769 |
| C045645 | cilostazol | cilostazol results in increased phosphorylation of SIRT1 protein | 24254769 |
| C045645 | cilostazol | CSNK2A1 protein affects the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] | 24254769 |
| C045645 | cilostazol | "(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]" | 24254769 |
| C045645 | cilostazol | KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] | 24254769 |
| C045645 | cilostazol | KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] | 24254769 |
| C045645 | cilostazol | SIRT1 protein affects the reaction [cilostazol affects the acetylation of and affects the phosphorylation of MAPT protein] | 24254769 |
| C045645 | cilostazol | SIRT1 protein affects the reaction [cilostazol affects the expression of EP300 protein] | 24254769 |
| C045645 | cilostazol | SIRT1 protein affects the reaction [cilostazol affects the phosphorylation of GSK3B protein] | 24254769 |
| C045645 | cilostazol | sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] | 24254769 |
| C045645 | cilostazol | sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] | 24254769 |
| D002994 | Clofibrate | [Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA | 17585979 |
| D002994 | Clofibrate | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SIRT1 mRNA] | 17585979 |
| D003035 | Cobalt | [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA | 18078969 |
| C007095 | cobaltiprotoporphyrin | cobaltiprotoporphyrin results in increased expression of SIRT1 mRNA | 26026874 |
| C007095 | cobaltiprotoporphyrin | cobaltiprotoporphyrin results in increased expression of SIRT1 protein | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of ACACA mRNA | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of FASN mRNA | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 mRNA | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of SREBF1 mRNA | 26026874 |
| C007095 | cobaltiprotoporphyrin | [SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of SREBF1 protein | 26026874 |
| C007095 | cobaltiprotoporphyrin | SIRT1 gene mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]] | 26026874 |
| C007095 | cobaltiprotoporphyrin | SIRT1 gene mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]] | 26026874 |
| C007095 | cobaltiprotoporphyrin | SIRT1 gene mutant form results in decreased susceptibility to cobaltiprotoporphyrin | 26026874 |
| C007095 | cobaltiprotoporphyrin | stannous mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of SIRT1 protein] | 26026874 |
| C007095 | cobaltiprotoporphyrin | stannous mesoporphyrin inhibits the reaction [[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein] | 26026874 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of SIRT1 protein | 22245592 |
| C018021 | cobaltous chloride | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] | 26174951 |
| C018021 | cobaltous chloride | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]] | 26174951 |
| C018021 | cobaltous chloride | [cobaltous chloride co-treated with sirtinol] results in decreased expression of SIRT1 protein | 22275802 |
| C018021 | cobaltous chloride | [cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of SIRT1 protein | 24319332 |
| C018021 | cobaltous chloride | resveratrol inhibits the reaction [[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of SIRT1 protein] | 24319332 |
| C018021 | cobaltous chloride | cobaltous chloride results in increased expression of SIRT1 protein | 22669716 |
| C018021 | cobaltous chloride | pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] | 22669716 |
| C018021 | cobaltous chloride | sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] | 22669716 |
| D009243 | NAD | [resveratrol results in increased abundance of NAD] which results in increased expression of SIRT1 protein | 19928762 |
| D009243 | NAD | [MIR34A mRNA results in decreased abundance of NAD] which results in decreased activity of SIRT1 protein | 23834033 |
| D009243 | NAD | NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310 |
| D009243 | NAD | NAD results in increased activity of SIRT1 protein | 19288225|2256131 |
| D009243 | NAD | Niacinamide inhibits the reaction [SIRT1 protein results in decreased abundance of NAD] | 19288225 |
| D009243 | NAD | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| D009243 | NAD | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| D009243 | NAD | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| D009243 | NAD | SIRT1 protein results in decreased abundance of NAD | 19288225 |
| D009243 | NAD | SIRT1 protein results in increased susceptibility to NAD | 22561310 |
| D009243 | NAD | NAD affects the activity of SIRT1 protein | 23834033|2417829 |
| D005576 | Colforsin | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]] | 23292070 |
| D005576 | Colforsin | SIRT1 protein inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] | 23292070 |
| D005576 | Colforsin | SIRT1 protein mutant form inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] | 23292070 |
| D005576 | Colforsin | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Colforsin results in increased expression of CRTC2 protein modified form] | 18849969 |
| D003300 | Copper | [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA | 24690739 |
| D019327 | Copper Sulfate | Copper Sulfate results in increased expression of SIRT1 mRNA | 19549813 |
| D003375 | Coumestrol | Coumestrol results in decreased expression of SIRT1 mRNA | 19167446 |
| C408982 | CPG-oligonucleotide | CPG-oligonucleotide results in decreased expression of SIRT1 mRNA | 21878529 |
| C408982 | CPG-oligonucleotide | CPG-oligonucleotide results in decreased expression of SIRT1 protein | 21878529 |
| C542041 | cudraflavone B | cudraflavone B results in increased expression of SIRT1 mRNA | 23881456 |
| C542041 | cudraflavone B | cudraflavone B results in increased expression of SIRT1 protein | 23881456 |
| C542041 | cudraflavone B | resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] | 23881456 |
| C542041 | cudraflavone B | resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 protein] | 23881456 |
| C542041 | cudraflavone B | sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] | 23881456 |
| C542041 | cudraflavone B | sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein] | 23881456 |
| D003474 | Curcumin | Curcumin results in increased expression of SIRT1 mRNA | 18403477 |
| D016572 | Cyclosporine | Cyclosporine results in increased expression of SIRT1 mRNA | 25562108 |
| D003566 | Cytidine Diphosphate Choline | Cytidine Diphosphate Choline results in increased expression of and results in increased activity of SIRT1 protein | 23600725 |
| D003566 | Cytidine Diphosphate Choline | Cytidine Diphosphate Choline results in increased expression of SIRT1 protein | 23600725 |
| D003676 | Deferoxamine | Deferoxamine results in increased expression of SIRT1 protein | 22245592 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone results in decreased expression of SIRT1 protein | 20195491 |
| D003687 | Dehydroepiandrosterone | Dehydroepiandrosterone affects the expression of SIRT1 protein | 20195491 |
| D019314 | Dehydroepiandrosterone Sulfate | Dehydroepiandrosterone Sulfate results in increased expression of SIRT1 protein | 25786523 |
| D003907 | Dexamethasone | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] | 26435214 |
| D003907 | Dexamethasone | Dexamethasone results in increased expression of SIRT1 mRNA | 19853017 |
| D003907 | Dexamethasone | SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] | 26435214 |
| D003907 | Dexamethasone | SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]] | 26435214 |
| D003907 | Dexamethasone | SIRT1 protein results in increased susceptibility to [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] | 26435214 |
| D003907 | Dexamethasone | [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| D003907 | Dexamethasone | [rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| D003907 | Dexamethasone | Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein] | 20181797 |
| D003907 | Dexamethasone | [Dexamethasone promotes the reaction [FOXO1 protein binds to SIRT1 protein]] which results in decreased acetylation of FOXO1 protein | 20181797 |
| D003907 | Dexamethasone | SIRT1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA] | 17884810 |
| D003907 | Dexamethasone | SIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]] | 17884810 |
| D016264 | Dextran Sulfate | ADAM17 protein affects the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA] | 24548422 |
| D016264 | Dextran Sulfate | Dextran Sulfate results in decreased expression of SIRT1 mRNA | 24548422 |
| D016264 | Dextran Sulfate | Dextran Sulfate results in decreased expression of SIRT1 protein | 19940103 |
| D016264 | Dextran Sulfate | resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA] | 24548422 |
| D016264 | Dextran Sulfate | resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 protein] | 19940103 |
| D002945 | Cisplatin | [Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA | 27392435 |
| D002945 | Cisplatin | SIRT1 protein results in decreased susceptibility to Cisplatin | 21416250 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein | 21593185 |
| D002945 | Cisplatin | Cisplatin results in increased expression of SIRT1 protein | 26723870 |
| D002945 | Cisplatin | NQO1 gene mutant form inhibits the reaction [Cisplatin results in increased expression of SIRT1 protein] | 26723870 |
| D002945 | Cisplatin | resveratrol inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein] | 21593185 |
| D002945 | Cisplatin | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]] | 21593185 |
| D002945 | Cisplatin | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]] | 21593185 |
| D002945 | Cisplatin | Cisplatin results in increased expression of SIRT1 protein | 21416250 |
| C036042 | dicyclohexyl phthalate | dicyclohexyl phthalate results in increased expression of SIRT1 mRNA | 26924002 |
| D004041 | Dietary Fats | [resveratrol analog co-treated with Dietary Fats] results in increased expression of SIRT1 mRNA | 24759758 |
| D004041 | Dietary Fats | Dietary Fats inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] | 25440059 |
| D004041 | Dietary Fats | Dietary Fats results in decreased activity of SIRT1 protein | 25943029 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SIRT1 mRNA | 24025686|2481266 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SIRT1 protein | 24025686|2446501 |
| D004041 | Dietary Fats | [Dietary Sucrose co-treated with Dietary Fats] results in increased oxidation of and results in decreased activity of SIRT1 protein | 24451382 |
| D004041 | Dietary Fats | Quercetin inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 24025686 |
| D004041 | Dietary Fats | Quercetin inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 protein] | 24025686|2446501 |
| D004041 | Dietary Fats | [resveratrol co-treated with Dietary Fats] results in increased expression of SIRT1 mRNA | 24985011 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 24812660 |
| D004041 | Dietary Fats | SIRT1 gene mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]] | 26026874 |
| D004041 | Dietary Fats | SIRT1 gene mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]] | 26026874 |
| D004041 | Dietary Fats | SIRT1 gene mutant form results in increased susceptibility to Dietary Fats | 26026874 |
| D004041 | Dietary Fats | SIRT1 protein results in decreased susceptibility to Dietary Fats | 24442997 |
| D004041 | Dietary Fats | [Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 mRNA | 22284404 |
| D004041 | Dietary Fats | [Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 protein | 22284404 |
| D004041 | Dietary Fats | Dietary Fats results in decreased activity of SIRT1 protein | 21632075 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SIRT1 mRNA | 22327056|2522814 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of SIRT1 protein | 25228148|2568656 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 mRNA] | 22284404 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 protein] | 22284404 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [Dietary Fats results in decreased activity of SIRT1 protein] | 21632075 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 25849131 |
| D004041 | Dietary Fats | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 protein] | 25228148|2568656 |
| D004041 | Dietary Fats | Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 22327056 |
| D019422 | Dietary Sucrose | [Dietary Sucrose co-treated with Dietary Fats] results in increased oxidation of and results in decreased activity of SIRT1 protein | 24451382 |
| D019422 | Dietary Sucrose | [Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 mRNA | 22284404 |
| D019422 | Dietary Sucrose | [Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 protein | 22284404 |
| D019422 | Dietary Sucrose | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 mRNA] | 22284404 |
| D019422 | Dietary Sucrose | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 protein] | 22284404 |
| D004052 | Diethylnitrosamine | AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of SIRT1 mRNA] | 19996281 |
| D004052 | Diethylnitrosamine | Diethylnitrosamine results in decreased expression of SIRT1 mRNA | 19996281 |
| C024629 | dimethyl phthalate | dimethyl phthalate affects the expression of SIRT1 mRNA | 26924002 |
| D004221 | Disulfiram | [Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA | 24690739 |
| D004317 | Doxorubicin | Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein | 28456571 |
| D004317 | Doxorubicin | Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of NRF1 protein] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of PPARGC1A protein] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of TFAM protein] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Doxorubicin results in decreased expression of VDAC1 protein] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]] | 28456571 |
| D004317 | Doxorubicin | SIRT1 protein affects the susceptibility to Doxorubicin | 19839049 |
| D004317 | Doxorubicin | SIRT1 protein results in decreased susceptibility to Doxorubicin | 28456571 |
| D004317 | Doxorubicin | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]" | 25665036|2645094 |
| D004317 | Doxorubicin | Doxorubicin results in decreased activity of SIRT1 protein | 25665036|2645094 |
| D004317 | Doxorubicin | resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein] | 25665036|2645094 |
| D004317 | Doxorubicin | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]] | 25665036|2645094 |
| D004317 | Doxorubicin | SIRT1 protein results in decreased susceptibility to Doxorubicin | 26712469 |
| C000590659 | (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid | "(E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]" | 24254769 |
| C031818 | enterotoxin B, staphylococcal | "enterotoxin B, staphylococcal results in decreased expression of SIRT1 protein" | 22646800 |
| C031818 | enterotoxin B, staphylococcal | "[resveratrol co-treated with enterotoxin B, staphylococcal] results in increased expression of SIRT1 mRNA" | 22646800 |
| C031818 | enterotoxin B, staphylococcal | "resveratrol inhibits the reaction [enterotoxin B, staphylococcal results in decreased expression of SIRT1 protein]" | 22646800 |
| D020536 | Enzyme Activators | Enzyme Activators results in increased activity of SIRT1 protein | 25707573 |
| D020536 | Enzyme Activators | [Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 mRNA] | 25707573 |
| D020536 | Enzyme Activators | [Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of ACTA2 protein] | 25707573 |
| D020536 | Enzyme Activators | [Enzyme Activators results in increased activity of SIRT1 protein] inhibits the reaction [TGFB2 protein results in increased expression of EP300 protein] | 25707573 |
| D020536 | Enzyme Activators | [Enzyme Activators results in increased activity of SIRT1 protein] which results in decreased expression of ACTA2 protein | 25707573 |
| D020536 | Enzyme Activators | [Enzyme Activators results in increased activity of SIRT1 protein] which results in decreased expression of EP300 protein | 25707573 |
| D004791 | Enzyme Inhibitors | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SIRT1 protein | 23301498 |
| C062669 | epicatechin gallate | [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] | 29061316 |
| C045651 | epigallocatechin gallate | [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] | 29061316 |
| C045651 | epigallocatechin gallate | [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein | 22742579 |
| D004875 | Ergosterol | [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA | 25833014 |
| D004875 | Ergosterol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] | 25833014 |
| D004921 | Erythropoietin | Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of SIRT1 protein] | 28456571 |
| D004921 | Erythropoietin | Erythropoietin results in increased expression of and results in increased activity of SIRT1 protein | 28456571 |
| D004921 | Erythropoietin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of NRF1 protein]] | 28456571 |
| D004921 | Erythropoietin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]] | 28456571 |
| D004921 | Erythropoietin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of TFAM protein]] | 28456571 |
| D004921 | Erythropoietin | SIRT1 protein affects the reaction [Erythropoietin inhibits the reaction [Doxorubicin results in decreased expression of VDAC1 protein]] | 28456571 |
| D000431 | Ethanol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Ethanol results in decreased expression of SIRT1 protein]" | 27989594 |
| D000431 | Ethanol | Ethanol results in decreased expression of SIRT1 protein | 24224909|2798959 |
| D000431 | Ethanol | resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24224909 |
| D000431 | Ethanol | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 27989594 |
| D000431 | Ethanol | acanthoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 28964808 |
| D000431 | Ethanol | Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24892905 |
| D000431 | Ethanol | Ethanol promotes the reaction [resveratrol results in increased expression of SIRT1 protein] | 18755807 |
| D000431 | Ethanol | Ethanol results in decreased activity of SIRT1 protein | 18239056 |
| D000431 | Ethanol | [Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of and results in increased localization of and results in increased activity of SREBF1 protein | 18239056 |
| D000431 | Ethanol | [Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein | 18755807 |
| D000431 | Ethanol | Ethanol results in decreased expression of and results in decreased activity of SIRT1 protein | 18755807 |
| D000431 | Ethanol | Ethanol results in decreased expression of SIRT1 mRNA | 18755807|2000785 |
| D000431 | Ethanol | Ethanol results in decreased expression of SIRT1 protein | 20007851|2409592 |
| D000431 | Ethanol | [resveratrol co-treated with Ethanol] results in increased expression of SIRT1 mRNA | 18755807 |
| D000431 | Ethanol | resveratrol inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein] | 18755807 |
| D000431 | Ethanol | resveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein] | 18755807 |
| D000431 | Ethanol | resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 18755807 |
| D000431 | Ethanol | rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 20007851 |
| D000431 | Ethanol | thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 27688165 |
| D000431 | Ethanol | [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein | 26854922 |
| D000431 | Ethanol | Ethanol results in decreased expression of SIRT1 mRNA | 24769256 |
| D000431 | Ethanol | Ethanol results in decreased expression of SIRT1 protein | 24769256|2685492 |
| D000431 | Ethanol | Ethanol results in increased expression of SIRT1 mRNA | 18793633 |
| D000431 | Ethanol | naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] | 18793633 |
| D000431 | Ethanol | resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] | 18793633 |
| D000431 | Ethanol | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 24769256 |
| D000431 | Ethanol | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24769256|2798959 |
| D000431 | Ethanol | SIRT1 protein affects the reaction [Ethanol results in increased expression of MLXIPL protein] | 27989594 |
| D000431 | Ethanol | SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]] | 27989594 |
| D000431 | Ethanol | SIRT1 protein inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein] | 18239056 |
| D005038 | Ethylnitrosourea | Ethylnitrosourea results in increased mutagenesis of SIRT1 exon | 17156454 |
| D000068338 | Everolimus | Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D000068338 | Everolimus | cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D000068338 | Everolimus | Everolimus results in decreased expression of SIRT1 protein | 19520256 |
| D018690 | Excitatory Amino Acid Agonists | Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein | 19288225 |
| D018690 | Excitatory Amino Acid Agonists | Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein] | 19288225 |
| D015073 | 2-Acetylaminofluorene | 2-Acetylaminofluorene results in increased expression of SIRT1 protein | 19167416 |
| D005632 | Fructose | Fructose results in increased expression of SIRT1 protein | 18192211 |
| D005632 | Fructose | SIRT1 protein affects the reaction [Fructose results in increased expression of MYH6 mRNA] | 18192211 |
| D005632 | Fructose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]" | 21212096 |
| D005632 | Fructose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]" | 21212096 |
| D005632 | Fructose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA]" | 21212096 |
| D005632 | Fructose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA]" | 21212096 |
| D005632 | Fructose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose" | 21212096 |
| D005632 | Fructose | Fructose results in decreased expression of SIRT1 mRNA | 26488877 |
| D005632 | Fructose | Fructose results in decreased expression of SIRT1 protein | 25108154 |
| D005632 | Fructose | Fructose results in increased expression of and results in increased activity of SIRT1 protein | 21212096 |
| D005632 | Fructose | Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] | 25108154 |
| D005632 | Fructose | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol] | 21212096 |
| D005632 | Fructose | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose] | 21212096 |
| D005632 | Fructose | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA] | 21212096 |
| D005632 | Fructose | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] | 21212096 |
| D005632 | Fructose | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose | 21212096 |
| D005632 | Fructose | resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA] | 26488877 |
| D005632 | Fructose | resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] | 25108154 |
| C070081 | fulvestrant | fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]] | 24771768 |
| D005690 | Galactose | [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 27358235 |
| D005690 | Galactose | Galactose results in decreased expression of SIRT1 protein | 25892055 |
| D005690 | Galactose | Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] | 25892055 |
| D005707 | Gallic Acid | [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] | 29061316 |
| C057580 | gallocatechol | [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] | 29061316 |
| C007834 | genipin | genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 28477916 |
| C007834 | genipin | sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 28477916 |
| D019833 | Genistein | Genistein affects the localization of SIRT1 protein | 18431742 |
| D019833 | Genistein | "Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 mRNA]" | 28688900 |
| D019833 | Genistein | "Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]" | 28688900 |
| D019833 | Genistein | Genistein inhibits the reaction [SIRT1 protein binds to FOXO3 promoter] | 18431742 |
| D019833 | Genistein | Genistein inhibits the reaction [SIRT1 protein binds to TP53 promoter] | 18431742 |
| D019833 | Genistein | [Genistein results in decreased activity of SIRT1 protein] which results in decreased acetylation of HIST3H3 protein | 18431742 |
| D019833 | Genistein | Genistein results in decreased expression of SIRT1 mRNA | 18431742 |
| D019833 | Genistein | "MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]]" | 28688900 |
| D019833 | Genistein | "SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]" | 28688900 |
| D019833 | Genistein | SIRT1 protein results in increased susceptibility to Genistein | 28688900 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 protein | 22284404 |
| D005947 | Glucose | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22284404 |
| D005947 | Glucose | sirtinol inhibits the reaction [Glucose results in increased expression of SIRT1 protein] | 22284404 |
| D005947 | Glucose | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Glucose co-treated with resveratrol] results in increased expression of SIRT1 protein]" | 24064760 |
| D005947 | Glucose | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]" | 21163946 |
| D005947 | Glucose | GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] | 24451382 |
| D005947 | Glucose | GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein] | 24451382 |
| D005947 | Glucose | [Glucose co-treated with resveratrol] results in increased expression of SIRT1 protein | 24064760 |
| D005947 | Glucose | [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 27358235 |
| D005947 | Glucose | Glucose deficiency results in increased expression of SIRT1 mRNA | 20195491 |
| D005947 | Glucose | Glucose deficiency results in increased expression of SIRT1 protein | 20195491|2480218 |
| D005947 | Glucose | Glucose deficiency results in increased phosphorylation of SIRT1 protein | 26811028 |
| D005947 | Glucose | Glucose results in decreased expression of and results in decreased activity of SIRT1 protein | 19071085 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 mRNA | 20068143|2177842 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 protein | 20068143 |
| D005947 | Glucose | [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein] | 24451382 |
| D005947 | Glucose | [Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein | 24451382 |
| D005947 | Glucose | PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein]] | 18482975 |
| D005947 | Glucose | PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]] | 18482975 |
| D005947 | Glucose | PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]] | 18482975 |
| D005947 | Glucose | [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein | 19071085 |
| D005947 | Glucose | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA] | 27049278 |
| D005947 | Glucose | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] | 18482975 |
| D005947 | Glucose | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein] | 18482975 |
| D005947 | Glucose | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides] | 18482975 |
| D005947 | Glucose | SIRT1 inhibits the reaction [Glucose results in increased expression of SHC1] | 23993977 |
| D005947 | Glucose | SIRT1 mutant form promotes the reaction [Glucose results in increased expression of SHC1 mRNA] | 21778425 |
| D005947 | Glucose | SIRT1 mutant form promotes the reaction [Glucose results in increased expression of SHC1 protein] | 21778425 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] | 20960276 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]] | 20960276 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]] | 20960276 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [Glucose results in decreased phosphorylation of ACACA protein] | 18482975 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides] | 18482975 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein] | 18482975 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [Glucose results in increased expression of SHC1 mRNA] | 21778425 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [Glucose results in increased expression of SHC1 protein] | 21778425 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased acetylation of TP53 protein] | 24451382 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased cleavage of CASP3 protein] | 24451382 |
| D005947 | Glucose | SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]] | 21163946 |
| D005947 | Glucose | SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of BBC3 mRNA] | 24451382 |
| D005947 | Glucose | SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA] | 24451382 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides] | 18482975 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]] | 20068143 |
| D005947 | Glucose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Glucose" | 20370652 |
| D005947 | Glucose | AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 protein | 20370652|2309018 |
| D005947 | Glucose | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA] | 19303870 |
| D005947 | Glucose | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein] | 19303870 |
| D005947 | Glucose | Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| D005947 | Glucose | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA | 19303870 |
| D005947 | Glucose | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein | 19303870 |
| D005947 | Glucose | PRKAA1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]] | 23090186 |
| D005947 | Glucose | PRKAA2 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]] | 23090186 |
| D005947 | Glucose | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| D005947 | Glucose | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of BAD protein] | 20370652 |
| D005947 | Glucose | [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose | 20370652 |
| D005947 | Glucose | [resveratrol results in increased localization of and results in increased activity of SIRT1 protein] which results in decreased susceptibility to Glucose | 20370652 |
| D005947 | Glucose | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]] | 19303870 |
| D005947 | Glucose | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] | 19303870 |
| D005947 | Glucose | SIRT1 protein affects the abundance of Glucose | 18849969 |
| D005947 | Glucose | [SIRT1 protein co-treated with resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein] | 23090186 |
| D005947 | Glucose | SIRT1 protein results in decreased susceptibility to Glucose | 20370652 |
| D005947 | Glucose | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose | 20370652 |
| D005947 | Glucose | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose]" | 21212096 |
| D005947 | Glucose | Glucose affects the expression of SIRT1 protein | 24349266 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 mRNA | 26891083 |
| D005947 | Glucose | Glucose results in decreased expression of SIRT1 protein | 22561310|2516282 |
| D005947 | Glucose | Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 25162824 |
| D005947 | Glucose | MIR217 mRNA affects the reaction [Glucose results in decreased expression of SIRT1 mRNA] | 26891083 |
| D005947 | Glucose | MIR217 mRNA affects the reaction [Glucose results in decreased expression of SIRT1 protein] | 26891083 |
| D005947 | Glucose | NAD inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310 |
| D005947 | Glucose | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose] | 21212096 |
| D005947 | Glucose | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310|2689108 |
| D005947 | Glucose | Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CTGF protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of TGFB1 protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]] | 26891083 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] | 16366736 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [[Glucose results in increased abundance of Adenosine Triphosphate] which results in increased expression of INS1 protein] | 16366736 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein] | 16366736 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| D005947 | Glucose | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| D005947 | Glucose | [SIRT1 protein results in decreased expression of UCP2 mRNA] promotes the reaction [Glucose results in increased abundance of Adenosine Triphosphate] | 16366736 |
| D005947 | Glucose | SIRT1 protein results in increased susceptibility to Glucose | 16366736 |
| D005947 | Glucose | [SRT1720 results in increased activity of SIRT1 protein] which results in increased abundance of Glucose | 21212096 |
| D005947 | Glucose | UCP2 protein inhibits the reaction [SIRT1 protein promotes the reaction [Glucose results in increased expression of INS1 protein]] | 16366736 |
| D005947 | Glucose | Glucose results in decreased activity of SIRT1 protein | 24894401 |
| D005978 | Glutathione | GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] | 24451382 |
| D005978 | Glutathione | [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein] | 24451382 |
| D019695 | Glycyrrhizic Acid | Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 25162824 |
| C425931 | GW 501516 | GW 501516 promotes the reaction [PPARD protein results in increased expression of SIRT1 mRNA] | 20160399 |
| D066248 | High Fructose Corn Syrup | High Fructose Corn Syrup results in decreased expression of SIRT1 mRNA | 25238689 |
| D066248 | High Fructose Corn Syrup | High Fructose Corn Syrup results in decreased expression of SIRT1 protein | 25238689 |
| D066248 | High Fructose Corn Syrup | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of SIRT1 mRNA] | 25238689 |
| D066248 | High Fructose Corn Syrup | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of SIRT1 protein] | 25238689 |
| D006859 | Hydrogen | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]" | 26271894 |
| D006859 | Hydrogen | Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] | 26271894 |
| D006859 | Hydrogen | Hydrogen results in increased expression of SIRT1 protein | 26271894 |
| D006861 | Hydrogen Peroxide | [Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of SIRT1 protein] | 29061316 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide affects the expression of SIRT1 mRNA | 20044591 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide affects the expression of SIRT1 protein | 29061316 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide affects the localization of SIRT1 protein | 25512378 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] | 24451382 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] | 24451382 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide promotes the reaction [SIRT1 protein binds to CAV1 protein] | 25512378 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 | 18681908 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 mRNA | 27049278 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 protein | 23859249|2570757 |
| D006861 | Hydrogen Peroxide | lycopene inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 28974442 |
| D006861 | Hydrogen Peroxide | [Niacinamide results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| D006861 | Hydrogen Peroxide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide | 18681908 |
| D006861 | Hydrogen Peroxide | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 mRNA] | 27049278 |
| D006861 | Hydrogen Peroxide | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 23859249 |
| D006861 | Hydrogen Peroxide | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| D006861 | Hydrogen Peroxide | [resveratrol results in increased activity of SIRT1 protein] which results in decreased susceptibility to Hydrogen Peroxide | 18681908 |
| D006861 | Hydrogen Peroxide | SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of SIRT1 protein] | 25512378 |
| D006861 | Hydrogen Peroxide | SIRT1 protein inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| D006861 | Hydrogen Peroxide | SIRT1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of SHC1 mRNA] | 21778425 |
| D006861 | Hydrogen Peroxide | SIRT1 protein results in decreased susceptibility to Hydrogen Peroxide | 18681908 |
| D006861 | Hydrogen Peroxide | [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| D006861 | Hydrogen Peroxide | [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide | 18681908 |
| D006861 | Hydrogen Peroxide | Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] | 20335659 |
| D006861 | Hydrogen Peroxide | [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein | 23293585 |
| D006861 | Hydrogen Peroxide | resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] | 23293585 |
| D006861 | Hydrogen Peroxide | SIRT1 mutant form inhibits the reaction [CAV1 gene mutant form inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TRP53 protein]] | 25512378 |
| D006861 | Hydrogen Peroxide | SIRT1 mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of PTGS2 mRNA] | 20335659 |
| D006861 | Hydrogen Peroxide | SIRT1 mutant form inhibits the reaction [Hydrogen Peroxide results in increased expression of PTGS2 protein] | 20335659 |
| D006861 | Hydrogen Peroxide | SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] | 20335659 |
| D006861 | Hydrogen Peroxide | SIRT1 protein affects the reaction [CAV1 protein affects the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]] | 25512378 |
| D006861 | Hydrogen Peroxide | SIRT1 results in decreased susceptibility to Hydrogen Peroxide | 20335659 |
| D006861 | Hydrogen Peroxide | bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] | 24889822 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 mRNA | 24349266 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 protein | 23891692|2434926 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased expression of SIRT1 protein | 17581637 |
| D006861 | Hydrogen Peroxide | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 23891692 |
| D006861 | Hydrogen Peroxide | SIRT1 protein affects the reaction [[Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of NDUFA13 protein] | 23891692 |
| D006861 | Hydrogen Peroxide | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]] | 24889822 |
| D006861 | Hydrogen Peroxide | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]] | 24889822 |
| D006861 | Hydrogen Peroxide | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]] | 24889822 |
| D006861 | Hydrogen Peroxide | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Hydrogen Peroxide]] | 18424637 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide promotes the reaction [FOXO1 protein binds to SIRT1 protein] | 15788402 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased expression of SIRT1 | 24894401 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in increased localization of [FOXO1 protein binds to SIRT1 protein] | 15788402 |
| C031927 | hydroquinone | SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of ATG5 mRNA] | 28263894 |
| C031927 | hydroquinone | SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of BECN1 mRNA] | 28263894 |
| D020155 | 3-Hydroxybutyric Acid | 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] | 25440059 |
| C021304 | hyperoside | hyperoside inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of SIRT1 protein] | 18552516 |
| C056599 | icariin | icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 25472572 |
| C056599 | icariin | icariin results in increased expression of SIRT1 mRNA | 25472572 |
| C056599 | icariin | icariin results in increased expression of SIRT1 protein | 25472572 |
| C056599 | icariin | Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 25472572 |
| C056599 | icariin | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA] | 19303870 |
| C056599 | icariin | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein] | 19303870 |
| C056599 | icariin | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]] | 19303870 |
| C056599 | icariin | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] | 19303870 |
| C056599 | icariin | icariin affects the expression of SIRT1 mRNA | 25472572 |
| C056599 | icariin | icariin affects the expression of SIRT1 protein | 25472572 |
| C082359 | imidacloprid | imidacloprid results in decreased expression of SIRT1 protein | 27960282 |
| D007213 | Indomethacin | Indomethacin results in decreased expression of SIRT1 mRNA | 28201806 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIRT1 mRNA | 25613284 |
| D015759 | Ionomycin | Ionomycin results in increased expression of SIRT1 protein | 17581637 |
| D015056 | 1-Methyl-3-isobutylxanthine | [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] | 26435214 |
| D015056 | 1-Methyl-3-isobutylxanthine | SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]] | 26435214 |
| D015056 | 1-Methyl-3-isobutylxanthine | SIRT1 protein promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]] | 26435214 |
| D015056 | 1-Methyl-3-isobutylxanthine | SIRT1 protein results in increased susceptibility to [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] | 26435214 |
| D015056 | 1-Methyl-3-isobutylxanthine | [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| D015056 | 1-Methyl-3-isobutylxanthine | [rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| C027681 | isonicotinamide | isonicotinamide results in increased activity of SIRT1 protein | 21745208 |
| C027681 | isonicotinamide | isonicotinamide results in increased expression of SIRT1 mRNA | 21745208 |
| C544151 | jinfukang | [Cisplatin co-treated with jinfukang] results in decreased expression of SIRT1 mRNA | 27392435 |
| C544151 | jinfukang | jinfukang results in decreased expression of SIRT1 mRNA | 27392435 |
| C561695 | (+)-JQ1 compound | [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of SIRT1 protein | 25307878 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in increased expression of SIRT1 protein | 26212199 |
| C561695 | (+)-JQ1 compound | (+)-JQ1 compound results in increased expression of SIRT1 protein | 26212199 |
| D007608 | Kainic Acid | Kainic Acid results in decreased expression of SIRT1 protein | 18538940 |
| D007608 | Kainic Acid | Kainic Acid results in increased expression of SIRT1 protein | 18538940 |
| C057416 | KT 5720 | KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] | 24254769 |
| C057416 | KT 5720 | KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] | 24254769 |
| C432503 | licarin A | [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| D008055 | Lipids | Lipids results in decreased expression of SIRT1 mRNA | 22968147 |
| D008055 | Lipids | Lipids results in decreased expression of SIRT1 protein | 22968147 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "lipopolysaccharide, Escherichia coli O111 B4 affects the expression of SIRT1 mRNA" | 23625030 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SIRT1 protein" | 23625030|2705221 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of SIRT1 mRNA]" | 23625030 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SIRT1 protein]" | 23625030|2705221 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]]" | 23625030 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]" | 23625030 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 protein]]" | 23625030 |
| C440499 | lipopolysaccharide, Escherichia coli O111 B4 | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]]" | 23625030 |
| D008070 | Lipopolysaccharides | [Lipopolysaccharides co-treated with Bee Venoms] affects the expression of SIRT1 mRNA | 25561937 |
| D008070 | Lipopolysaccharides | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA | 23199342 |
| D008070 | Lipopolysaccharides | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein | 23199342 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased expression of SIRT1 | 23363613 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased expression of SIRT1 mRNA | 20844277|2611111 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in increased expression of SIRT1 | 22000456 |
| D008070 | Lipopolysaccharides | [resveratrol co-treated with Lipopolysaccharides] results in increased expression of SIRT1 mRNA | 20844277 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein] | 23199342 |
| D008070 | Lipopolysaccharides | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] | 20844277 |
| D008070 | Lipopolysaccharides | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]] | 20844277 |
| D008070 | Lipopolysaccharides | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]] | 20844277 |
| D008070 | Lipopolysaccharides | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| D008070 | Lipopolysaccharides | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| D008070 | Lipopolysaccharides | AICA ribonucleotide inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 24465016 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased activity of SIRT1 protein | 19279313 |
| D008070 | Lipopolysaccharides | Lipopolysaccharides results in decreased expression of SIRT1 protein | 22952890|2397330 |
| D008070 | Lipopolysaccharides | Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 24465016 |
| D008070 | Lipopolysaccharides | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased activity of SIRT1 protein] | 19279313 |
| D008070 | Lipopolysaccharides | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 22952890|2397330 |
| D008070 | Lipopolysaccharides | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 23973301 |
| D008070 | Lipopolysaccharides | wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 22952890 |
| D008070 | Lipopolysaccharides | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA] | 24289075 |
| D008070 | Lipopolysaccharides | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 protein] | 24289075 |
| D008070 | Lipopolysaccharides | [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA | 24289075 |
| D008070 | Lipopolysaccharides | [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 protein | 24289075 |
| C061091 | lithospermate B | lithospermate B inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in decreased localization of SIRT1 protein] | 21295052 |
| C061091 | lithospermate B | lithospermate B results in increased localization of SIRT1 protein | 21295052 |
| C057154 | luzindole | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] | 25159133 |
| C057154 | luzindole | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] | 25159133 |
| C015329 | lycopene | lycopene inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 28974442 |
| C005498 | magnolol | [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein | 28919305 |
| D008315 | Malondialdehyde | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] | 24633890 |
| C569869 | malondialdehyde-low density lipoprotein, human | "Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 mRNA]" | 28688900 |
| C569869 | malondialdehyde-low density lipoprotein, human | "Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]" | 28688900 |
| C569869 | malondialdehyde-low density lipoprotein, human | "malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 mRNA" | 28688900 |
| C569869 | malondialdehyde-low density lipoprotein, human | "malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein" | 28688900 |
| C569869 | malondialdehyde-low density lipoprotein, human | "MIR34A mRNA inhibits the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of SIRT1 protein]]" | 28688900 |
| C569869 | malondialdehyde-low density lipoprotein, human | "SIRT1 protein promotes the reaction [Genistein inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased acetylation of and affects the localization of FOXO3 protein]]" | 28688900 |
| C013099 | mancozeb | mancozeb results in decreased activity of SIRT1 protein | 21251949 |
| D008344 | Maneb | Maneb results in decreased activity of SIRT1 protein | 21251949 |
| D017258 | Medroxyprogesterone Acetate | [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of SIRT1 protein | 16709600 |
| D008550 | Melatonin | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]] | 25159133 |
| D008550 | Melatonin | luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]] | 25159133 |
| D008550 | Melatonin | Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein] | 25159133 |
| D008550 | Melatonin | Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein] | 25159133 |
| D008550 | Melatonin | Melatonin results in decreased expression of SIRT1 protein | 21062352 |
| D008550 | Melatonin | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| D008550 | Melatonin | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| D008550 | Melatonin | Melatonin results in decreased expression of SIRT1 protein | 21062352 |
| D008687 | Metformin | SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] | 23315983 |
| D008687 | Metformin | Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| D008687 | Metformin | Metformin results in increased expression of SIRT1 mRNA | 23166782|2468799 |
| D008687 | Metformin | SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA] | 24428821 |
| D008687 | Metformin | Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] | 25108154 |
| D008687 | Metformin | Metformin results in increased expression of SIRT1 protein | 25108154 |
| D008687 | Metformin | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin | 25108154 |
| C002950 | methylformamide | methylformamide analog results in increased expression of SIRT1 mRNA | 17040096 |
| C002950 | methylformamide | methylformamide results in increased expression of SIRT1 mRNA | 17040096 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in increased expression of SIRT1 mRNA | 26011545 |
| D018817 | N-Methyl-3,4-methylenedioxyamphetamine | "N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SIRT1 mRNA" | 26251327 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein | 25073091|2676836 |
| D015655 | 1-Methyl-4-phenylpyridinium | chikusetsusaponin V inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein] | 25073091 |
| D015655 | 1-Methyl-4-phenylpyridinium | SIRT1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HIF1A mRNA] | 26768367 |
| D015655 | 1-Methyl-4-phenylpyridinium | [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SIRT1 protein | 22742579 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in decreased expression of SIRT1 protein | 17583434|1853894 |
| D015655 | 1-Methyl-4-phenylpyridinium | 1-Methyl-4-phenylpyridinium results in increased expression of SIRT1 protein | 18538940 |
| D015655 | 1-Methyl-4-phenylpyridinium | [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA | 17583434 |
| D008775 | Methylprednisolone | Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] | 26930420 |
| C517284 | monomethyl phthalate | monomethyl phthalate results in increased expression of SIRT1 mRNA | 26924002 |
| C040015 | myricetin | myricetin results in increased activity of SIRT1 protein | 22245592 |
| C040015 | myricetin | [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein | 22245592 |
| C040015 | myricetin | [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein | 22245592 |
| C040015 | myricetin | [myricetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein | 22245592 |
| C040015 | myricetin | [myricetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein | 22245592 |
| C040015 | myricetin | myricetin results in increased expression of SIRT1 protein | 22245592 |
| C063509 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with TNF protein] results in decreased expression of SIRT1 protein | 24145604 |
| C063509 | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 25943029 |
| C539427 | N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide | [N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA | 22146233 |
| C539427 | N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide | N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide results in decreased activity of SIRT1 protein | 22146233 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in decreased expression of SIRT1 mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon results in decreased expression of SIRT1 mRNA" | 25554681 |
| C000621033 | napabucasin | napabucasin results in decreased expression of SIRT1 mRNA | 25605917 |
| C005274 | naringin | naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] | 18793633 |
| C017096 | n-butoxyethanol | n-butoxyethanol results in increased expression of SIRT1 mRNA | 19812364 |
| C022838 | nickel chloride | nickel chloride results in increased expression of SIRT1 mRNA | 17547211 |
| C018613 | nicotinamide-beta-riboside | nicotinamide-beta-riboside results in increased activity of SIRT1 protein | 17652729 |
| D009538 | Nicotine | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 mRNA | 23199342 |
| D009538 | Nicotine | [Lipopolysaccharides co-treated with Nicotine] results in increased expression of SIRT1 protein | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of CXCL8 mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL17A mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL1B mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of IL6 mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of PTGS2 protein] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of TNF mRNA] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of IL1B protein] | 23199342 |
| D009538 | Nicotine | SIRT1 protein inhibits the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased secretion of TNF protein] | 23199342 |
| D009538 | Nicotine | Nicotine results in decreased expression of SIRT1 mRNA | 22687363 |
| D009538 | Nicotine | resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] | 22687363 |
| C012655 | nimesulide | nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of SIRT1 mRNA] | 25339356 |
| D009569 | Nitric Oxide | SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide] | 20960276 |
| D009569 | Nitric Oxide | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] | 20960276 |
| D009573 | Nitrites | [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein | 22892143 |
| D009573 | Nitrites | [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA | 22892143 |
| D009573 | Nitrites | "P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA]" | 22892143 |
| D009573 | Nitrites | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased abundance of Nitrites] | 19008341 |
| D009599 | Nitroprusside | Nitroprusside results in increased expression of and results in increased activity of SIRT1 protein | 18204789 |
| C090577 | N,N'-bis(salicylideneamino)ethane-manganese(II) | "N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in increased expression of SIRT1 protein]" | 21195081 |
| C434926 | N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride | "SIRT1 results in increased susceptibility to N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride" | 25440059 |
| D019301 | Oleic Acid | [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein | 26854922 |
| D019301 | Oleic Acid | Oleic Acid results in increased expression of SIRT1 protein | 24349266 |
| D016627 | Oxidopamine | Oxidopamine results in decreased expression of SIRT1 protein | 18675900 |
| D016627 | Oxidopamine | puag-haad inhibits the reaction [Oxidopamine results in decreased expression of SIRT1 protein] | 18675900 |
| C000594117 | ON123300 | ON123300 results in increased expression of SIRT1 protein | 26873845 |
| D016566 | Organoselenium Compounds | Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 25301743 |
| D062907 | Oxaloacetic Acid | Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein | 26811028 |
| D010100 | Oxygen | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of CTNNB1] | 22245592 |
| D010100 | Oxygen | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of EGLN1 protein] | 22245592 |
| D010100 | Oxygen | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in decreased expression of MYC protein] | 22245592 |
| D010100 | Oxygen | [amurensin G results in decreased activity of SIRT1 protein] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | 22245592 |
| D010100 | Oxygen | icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 25472572 |
| D010100 | Oxygen | Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 25472572 |
| D010100 | Oxygen | Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]] | 24557422 |
| D010100 | Oxygen | Niacinamide promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| D010100 | Oxygen | [Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein | 25472572 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein | 24557422 |
| D010100 | Oxygen | Oxygen deficiency promotes the reaction [SIRT1 protein binds to HIF1A protein] | 22245592 |
| D010100 | Oxygen | Oxygen deficiency promotes the reaction [SIRT1 protein binds to MYC protein] | 22245592 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of SIRT1 protein | 25707573 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of SIRT1 mRNA | 22245592 |
| D010100 | Oxygen | Oxygen deficiency results in increased expression of SIRT1 protein | 22245592 |
| D010100 | Oxygen | resveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 25472572 |
| D010100 | Oxygen | resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| D010100 | Oxygen | salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein] | 25472572 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein] | 25472572 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of FOXO3 protein] | 25472572 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein] | 25472572 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein] | 24557422 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein] | 24557422 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein] | 24557422 |
| D010100 | Oxygen | SIRT1 mutant form promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein] | 24557422 |
| D010100 | Oxygen | SIRT1 protein affects the reaction [Oxygen deficiency results in decreased expression of CTNNB1 protein] | 22245592 |
| D010100 | Oxygen | SIRT1 protein affects the reaction [Oxygen deficiency results in decreased expression of MYC protein] | 22245592 |
| D010100 | Oxygen | SIRT1 protein affects the reaction [Oxygen deficiency results in increased expression of HIF1A protein] | 22245592 |
| D010100 | Oxygen | SIRT1 protein affects the susceptibility to Oxygen deficiency | 22245592 |
| D010100 | Oxygen | [cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of SIRT1 protein | 24319332 |
| D010100 | Oxygen | resveratrol inhibits the reaction [[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of SIRT1 protein] | 24319332 |
| D010100 | Oxygen | [Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein | 28477916 |
| D010100 | Oxygen | genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 28477916 |
| D010100 | Oxygen | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA] | 19303870 |
| D010100 | Oxygen | icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein] | 19303870 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA | 19303870 |
| D010100 | Oxygen | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein | 19303870 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of SIRT1 protein | 21113404 |
| D010100 | Oxygen | Oxygen results in decreased expression of SIRT1 protein | 25447406 |
| D010100 | Oxygen | [resveratrol co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA | 21113404 |
| D010100 | Oxygen | [rosiglitazone co-treated with Oxygen deficiency] results in increased expression of SIRT1 protein | 21113404 |
| D010100 | Oxygen | rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 protein] | 21113404 |
| D010100 | Oxygen | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]] | 19303870 |
| D010100 | Oxygen | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] | 19303870 |
| D010100 | Oxygen | sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 28477916 |
| D010100 | Oxygen | [Nitrites co-treated with Oxygen deficiency] results in increased activity of SIRT1 protein | 22892143 |
| D010100 | Oxygen | [Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA | 22892143 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of SIRT1 mRNA | 25352008 |
| D010100 | Oxygen | Oxygen deficiency results in decreased expression of SIRT1 protein | 25352008 |
| D010100 | Oxygen | "P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA]" | 22892143 |
| D010100 | Oxygen | resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 mRNA] | 25352008 |
| D010100 | Oxygen | resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 protein] | 25352008 |
| C012275 | P(1),P(5)-di(adenosine-5'-)pentaphosphate | "P(1),P(5)-di(adenosine-5'-)pentaphosphate analog inhibits the reaction [[Nitrites co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA]" | 22892143 |
| D017239 | Paclitaxel | Aspirin inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] | 19520256 |
| D017239 | Paclitaxel | cilostazol inhibits the reaction [Paclitaxel results in decreased expression of SIRT1 protein] | 19520256 |
| D017239 | Paclitaxel | Paclitaxel results in decreased expression of SIRT1 protein | 19520256 |
| D010168 | Palmitates | Palmitates results in decreased expression of SIRT1 mRNA | 20068143 |
| D010168 | Palmitates | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitates results in increased acetylation of TP53 protein]] | 20068143 |
| D019308 | Palmitic Acid | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]]" | 25943029 |
| D019308 | Palmitic Acid | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]" | 25943029 |
| D019308 | Palmitic Acid | GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]] | 24451382 |
| D019308 | Palmitic Acid | GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein] | 24451382 |
| D019308 | Palmitic Acid | [Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein] | 24451382 |
| D019308 | Palmitic Acid | [Palmitic Acid co-treated with Glucose] results in increased oxidation of and results in decreased activity of SIRT1 protein | 24451382 |
| D019308 | Palmitic Acid | Palmitic Acid results in decreased activity of SIRT1 protein | 25943029 |
| D019308 | Palmitic Acid | resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein] | 25943029 |
| D019308 | Palmitic Acid | SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased acetylation of TP53 protein] | 24451382 |
| D019308 | Palmitic Acid | SIRT1 protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased cleavage of CASP3 protein] | 24451382 |
| D019308 | Palmitic Acid | SIRT1 protein inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein] | 25943029 |
| D019308 | Palmitic Acid | SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of BBC3 mRNA] | 24451382 |
| D019308 | Palmitic Acid | SIRT1 protein mutant form inhibits the reaction [[Palmitic Acid co-treated with Glucose] results in increased expression of CDKN1A mRNA] | 24451382 |
| D019308 | Palmitic Acid | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]] | 25943029 |
| D019308 | Palmitic Acid | [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein | 26854922 |
| D019308 | Palmitic Acid | Palmitic Acid results in decreased expression of SIRT1 mRNA | 22968147 |
| D019308 | Palmitic Acid | Palmitic Acid results in decreased expression of SIRT1 protein | 25108154 |
| D019308 | Palmitic Acid | resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA] | 22968147 |
| D010269 | Paraquat | Paraquat affects the expression of SIRT1 protein | 26935021 |
| D010269 | Paraquat | Paraquat results in increased expression of SIRT1 mRNA | 26708779 |
| D010269 | Paraquat | Paraquat results in increased expression of SIRT1 protein | 22563483|2670877 |
| D010269 | Paraquat | resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 mRNA] | 26708779 |
| D010269 | Paraquat | resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 protein] | 26708779 |
| D010269 | Paraquat | SIRT1 protein affects the reaction [Paraquat affects the activity of CAT protein] | 26935021 |
| D010269 | Paraquat | SIRT1 protein affects the reaction [Paraquat affects the activity of HMOX1 protein] | 26935021 |
| D010269 | Paraquat | SIRT1 protein inhibits the reaction [Paraquat results in decreased stability of NFE2L2 protein] | 26935021 |
| C568608 | PCI 5002 | [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA | 18593933 |
| D010416 | Pentachlorophenol | Pentachlorophenol results in decreased expression of SIRT1 protein | 19442831 |
| C076994 | perfluorooctane sulfonic acid | perfluorooctane sulfonic acid affects the localization of and results in increased expression of and results in increased activity of and results in decreased phosphorylation of SIRT1 protein | 28973641 |
| D015232 | Dinoprostone | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]] | 23257246 |
| D015232 | Dinoprostone | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]] | 20844277 |
| D015232 | Dinoprostone | Dinoprostone inhibits the reaction [SIRT1 mutant form promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]] | 20335659 |
| D010629 | Phenformin | Phenformin results in decreased expression of SIRT1 protein | 26768367 |
| D010634 | Phenobarbital | Phenobarbital affects the expression of SIRT1 mRNA | 19159669 |
| D010634 | Phenobarbital | Phenobarbital affects the expression of SIRT1 mRNA | 23091169 |
| D019800 | Phenol | Phenol results in increased expression of SIRT1 mRNA | 17547211 |
| D010862 | Pilocarpine | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]" | 23211629 |
| D010862 | Pilocarpine | Niacinamide inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] | 23211629 |
| D010862 | Pilocarpine | Pilocarpine results in increased expression of SIRT1 protein | 23211629 |
| D010862 | Pilocarpine | resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein] | 23211629 |
| C004479 | pimagedine | [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein | 28919305 |
| D010936 | Plant Extracts | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts | 22563892 |
| D010936 | Plant Extracts | Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 23859249 |
| D010936 | Plant Extracts | Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA] | 23993977 |
| D010936 | Plant Extracts | Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 protein] | 23993977 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of SIRT1 mRNA | 23993977 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of SIRT1 protein | 23993977 |
| D010936 | Plant Extracts | salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 mRNA] | 23993977 |
| D010936 | Plant Extracts | salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 protein] | 23993977 |
| D010936 | Plant Extracts | Plant Extracts results in increased expression of SIRT1 protein | 20673376 |
| D010938 | Plant Oils | Plant Oils results in increased expression of SIRT1 mRNA | 23370395 |
| D008926 | Plicamycin | Plicamycin inhibits the reaction [PPARD protein results in increased expression of SIRT1 mRNA] | 20160399 |
| C008971 | polymarcine | polymarcine results in decreased activity of SIRT1 protein | 21251949 |
| D059808 | Polyphenols | Polyphenols results in increased expression of SIRT1 protein | 20673376 |
| D011188 | Potassium | Potassium affects the expression of SIRT1 mRNA | 17583434 |
| D011188 | Potassium | Potassium affects the expression of SIRT1 protein | 17583434 |
| D011285 | Pregnenolone Carbonitrile | SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] | 21933665 |
| C009041 | primycin | primycin results in increased expression of SIRT1 mRNA | 28916286 |
| D015237 | Dinoprost | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] | 20844277 |
| C107773 | pterostilbene | [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA | 26459286 |
| C107773 | pterostilbene | [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein | 26459286 |
| C034912 | puag-haad | puag-haad inhibits the reaction [Oxidopamine results in decreased expression of SIRT1 protein] | 18675900 |
| C432165 | pyrazolanthrone | pyrazolanthrone inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] | 22669716 |
| D011765 | Pyruvaldehyde | [magnolol co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein | 28919305 |
| D011765 | Pyruvaldehyde | [pimagedine co-treated with Pyruvaldehyde] results in increased expression of SIRT1 protein | 28919305 |
| D019289 | Pyruvic Acid | [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 27358235 |
| D019289 | Pyruvic Acid | [Pyruvic Acid co-treated with Glucose] results in increased expression of and results in increased activity of SIRT1 protein | 19071085 |
| D019289 | Pyruvic Acid | [PDK4 affects the abundance of Pyruvic Acid] which results in increased expression of SIRT1 | 21182459 |
| D019289 | Pyruvic Acid | Pyruvic Acid results in increased expression of SIRT1 mRNA | 21933665 |
| D019289 | Pyruvic Acid | SIRT1 mRNA affects the reaction [Pyruvic Acid inhibits the reaction [PPARGC1A protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A11 mRNA]]] | 21933665 |
| D011794 | Quercetin | MIR34A mRNA affects the reaction [Quercetin results in decreased expression of SIRT1 protein] | 25896587 |
| D011794 | Quercetin | Quercetin results in decreased expression of SIRT1 protein | 25896587 |
| D011794 | Quercetin | Quercetin results in increased activity of SIRT1 protein | 22245592 |
| D011794 | Quercetin | [Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein | 22245592 |
| D011794 | Quercetin | [Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein | 22245592 |
| D011794 | Quercetin | [Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein | 22245592 |
| D011794 | Quercetin | [Quercetin results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein | 22245592 |
| D011794 | Quercetin | Quercetin results in increased expression of SIRT1 protein | 22245592 |
| D011794 | Quercetin | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]" | 24465016 |
| D011794 | Quercetin | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin results in increased expression of SIRT1 protein]" | 24465016 |
| D011794 | Quercetin | Quercetin affects the activity of SIRT1 protein | 24025686 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 24025686 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 protein] | 24025686|2446501 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 24465016 |
| D011794 | Quercetin | Quercetin results in increased expression of SIRT1 mRNA | 19211721 |
| D011794 | Quercetin | Quercetin results in increased expression of SIRT1 protein | 24465016 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SIRT1 protein] | 28347707 |
| D017382 | Reactive Oxygen Species | SIRT1 protein affects the reaction [[Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of NDUFA13 protein] | 23891692 |
| C025474 | rebaudioside A | rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] | 25554529 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22284404 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 mRNA | 24314921 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 23712640|2431492 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]] | 22539994 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein] | 22539994 |
| C059514 | resveratrol | resveratrol inhibits the reaction [TNFSF11 protein results in decreased expression of SIRT1 protein] | 21239502 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein] | 21239502 |
| C059514 | resveratrol | [resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] inhibits the reaction [TNFSF11 protein results in increased acetylation of and results in increased activity of RELA protein] | 21239502 |
| C059514 | resveratrol | resveratrol promotes the reaction [[SIRT1 protein binds to EP300 protein] which binds to RUNX2 protein] | 21239502 |
| C059514 | resveratrol | [resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein | 21239502 |
| C059514 | resveratrol | [[resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein | 21239502 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein] | 21239502 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 protein | 22539994 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to RUNX2 protein] | 22539994 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 21239502|2253999 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased acetylation of RUNX2 protein] | 22539994 |
| C059514 | resveratrol | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of SIRT1]" | 24584901 |
| C059514 | resveratrol | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]" | 25943029 |
| C059514 | resveratrol | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [[TNF protein co-treated with resveratrol] results in increased expression of SIRT1 protein]" | 24145604 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[Glucose co-treated with resveratrol] results in increased expression of SIRT1 protein]" | 24064760 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]]" | 25943029 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased activity of SIRT1 protein]" | 24603648|2584913 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]" | 20426787 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SIRT1 mRNA]" | 23358928 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]" | 23358928 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]" | 21163946 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA]]" | 21163946 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]]" | 21163946 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of SLC2A2 mRNA]]" | 21163946 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]]" | 21163946 |
| C059514 | resveratrol | ELAVL1 mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 23814050 |
| C059514 | resveratrol | fulvestrant inhibits the reaction [[TNF protein co-treated with resveratrol] promotes the reaction [SIRT1 protein binds to IL6 promoter]] | 24771768 |
| C059514 | resveratrol | [Glucose co-treated with resveratrol] results in increased expression of SIRT1 protein | 24064760 |
| C059514 | resveratrol | [Glucose deficiency co-treated with Galactose co-treated with Amino Acids co-treated with Pyruvic Acid] inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 27358235 |
| C059514 | resveratrol | MAT2B mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 23814050 |
| C059514 | resveratrol | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 25943029 |
| C059514 | resveratrol | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 19928762 |
| C059514 | resveratrol | PARP1 protein affects the reaction [resveratrol results in increased expression of SIRT1 protein] | 25533949 |
| C059514 | resveratrol | PRKACA protein affects the reaction [[TNF protein co-treated with resveratrol] results in increased expression of SIRT1 protein] | 24145604 |
| C059514 | resveratrol | PRKACA protein promotes the reaction [resveratrol results in increased expression of SIRT1 protein] | 25943029 |
| C059514 | resveratrol | resveratrol affects the activity of SIRT1 protein | 24064760 |
| C059514 | resveratrol | resveratrol affects the localization of SIRT1 protein | 24587049 |
| C059514 | resveratrol | [resveratrol binds to and results in increased activity of SIRT1 protein] which results in decreased activity of ATXN3 protein mutant form | 17885668 |
| C059514 | resveratrol | [resveratrol co-treated with Lipopolysaccharides] results in increased expression of SIRT1 mRNA | 20844277 |
| C059514 | resveratrol | [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA | 26459286 |
| C059514 | resveratrol | [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein | 26459286 |
| C059514 | resveratrol | [resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein | 23257246 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24224909 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 mRNA] | 27049278 |
| C059514 | resveratrol | resveratrol inhibits the reaction [GSK3B protein binds to SIRT1 protein] | 23292070 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 mRNA] | 27049278 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 23859249 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein] | 25472572 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein] | 25943029 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein]] | 25991017 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 mRNA] | 25991017 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] | 25991017 |
| C059514 | resveratrol | resveratrol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]] | 24771768 |
| C059514 | resveratrol | resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] | 23881456 |
| C059514 | resveratrol | resveratrol promotes the reaction [cudraflavone B results in increased expression of SIRT1 protein] | 23881456 |
| C059514 | resveratrol | resveratrol promotes the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] | 23217256 |
| C059514 | resveratrol | resveratrol promotes the reaction [[LMNA protein binds to and results in increased activity of SIRT1 protein] which results in decreased acetylation of TP53 protein] | 23217256 |
| C059514 | resveratrol | resveratrol promotes the reaction [MAT2B protein binds to SIRT1 protein] | 23814050 |
| C059514 | resveratrol | resveratrol promotes the reaction [NOS3 protein binds to SIRT1 protein] | 23463510 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein] | 19047049 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein binds to BIRC3 promoter] | 15152190 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein binds to FOXO3 protein] | 21713995 |
| C059514 | resveratrol | resveratrol promotes the reaction [[SIRT1 protein binds to FOXO3 protein] which binds to RUNX2 3' UTR] | 21713995 |
| C059514 | resveratrol | resveratrol promotes the reaction [[[SIRT1 protein binds to FOXO3 protein] which binds to RUNX2 3' UTR] which results in increased expression of RUNX2 mRNA] | 21713995 |
| C059514 | resveratrol | resveratrol promotes the reaction [TNF protein results in increased expression of SIRT1 mRNA] | 23257246 |
| C059514 | resveratrol | resveratrol results in decreased activity of SIRT1 protein | 24429678 |
| C059514 | resveratrol | resveratrol results in decreased expression of SIRT1 mRNA | 21980390 |
| C059514 | resveratrol | resveratrol results in decreased expression of SIRT1 protein | 20195491|2395432 |
| C059514 | resveratrol | [resveratrol results in increased abundance of NAD] which results in increased expression of SIRT1 protein | 19928762 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 protein | 15749705|1710301 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] | 18482975 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein] | 18482975 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides] | 18482975 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein] | 20426787 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] | 20426787 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 mRNA] | 20978007 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 protein] | 20978007 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein] | 19047049 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of CTNNB1 protein | 19047049 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of RELA protein | 19047049 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to SCX protein] | 22936809 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein | 20169165 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein | 20169165 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of PARP1 protein | 16628003 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein | 22245592 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of CXCL8 mRNA | 24894820 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein | 22245592 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein | 22245592 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased phosphorylation of EIF4EBP1 protein | 20169165 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased phosphorylation of RPS6 protein | 20169165 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased susceptibility to Hydrogen Peroxide | 18681908 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of DEFB4A mRNA | 24894820 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of FOXO3 protein | 21713995 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein | 22245592 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA1 protein | 18482975 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA2 protein | 18482975 |
| C059514 | resveratrol | resveratrol results in increased expression of and affects the localization of SIRT1 protein | 25707573 |
| C059514 | resveratrol | resveratrol results in increased expression of and results in increased stability of SIRT1 protein | 23814050 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 | 21224254|2123846 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 mRNA | 20697895|2324809 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 16849586|1966464 |
| C059514 | resveratrol | [resveratrol results in increased expression of SIRT1] which results in decreased expression of MMP9 | 21238464 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of TP53 protein]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] | 23257246 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein] | 23248098 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of ELAVL1 protein] | 23814050 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B mRNA] | 23814050 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of MAT2B protein] | 23814050 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in increased expression of NR0B2 mRNA] | 26044878 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]] | 20960276 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]] | 20960276 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]] | 20960276 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] | 24145604 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] | 24145604 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] | 24145604 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased expression of MKI67 protein] | 26959057 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased expression of MMP9 protein] | 26959057 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased expression of STAT3 protein modified form] | 24064760 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of FOXO3 protein] | 23022493 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of MSRA protein] | 23022493 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of NOS3 mRNA] | 23583951 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of NOS3 protein] | 23583951 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of SOX9 protein] | 24962570 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [[TNF protein co-treated with resveratrol] results in increased expression of MAP1LC3B protein alternative form] | 24145604 |
| C059514 | resveratrol | SIRT1 protein affects the susceptibility to resveratrol | 22523472|2406476 |
| C059514 | resveratrol | [SIRT1 protein binds to SOX9 protein] which affects the susceptibility to resveratrol | 24962570 |
| C059514 | resveratrol | SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]] | 21163946 |
| C059514 | resveratrol | SIRT1 protein inhibits the reaction [resveratrol results in decreased expression of CXCR4 protein] | 26959057 |
| C059514 | resveratrol | SIRT1 protein inhibits the reaction [resveratrol results in increased acetylation of TP53 protein] | 24603648 |
| C059514 | resveratrol | SIRT1 protein inhibits the reaction [resveratrol results in increased secretion of NAMPT protein] | 24603648 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]] | 26174951 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]] | 26174951 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides] | 18482975 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]] | 20068143 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] | 20844277 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]] | 20844277 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]] | 20844277 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitates results in increased acetylation of TP53 protein]] | 20068143 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in decreased activity of SIRT1 protein]] | 25943029 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA alternative form]] | 25707573 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in decreased expression of and results in decreased secretion of CXCL8 protein] | 20463039 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in decreased expression of and results in decreased secretion of IL6 protein] | 20463039 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in decreased expression of REST mRNA] | 26307266 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in decreased expression of REST protein] | 26307266 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased degradation of SQSTM1 protein] | 25943029 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA] | 21163946 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of KLF2 mRNA] | 19815564 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA] | 21163946 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of SLC2A2 mRNA] | 21163946 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA] | 21163946 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of ACACA protein] | 18482975 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein] | 18482975 |
| C059514 | resveratrol | SIRT1 protein results in decreased susceptibility to resveratrol | 23248098 |
| C059514 | resveratrol | SIRT1 protein results in increased susceptibility to resveratrol | 19664641|2617495 |
| C059514 | resveratrol | sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein] | 23257246 |
| C059514 | resveratrol | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 20610621|2069789 |
| C059514 | resveratrol | [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] | 18482975 |
| C059514 | resveratrol | STK11 protein promotes the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein] | 18482975 |
| C059514 | resveratrol | [TNF protein co-treated with resveratrol] results in increased expression of SIRT1 protein | 24145604 |
| C059514 | resveratrol | TSC2 protein promotes the reaction [[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein] | 20169165 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[cobaltous chloride results in decreased abundance of Oxygen] which results in increased expression of SIRT1 protein] | 24319332 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein results in increased activity of FOXO4 protein] | 16012755 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased acetylation of and results in increased activity of FOXO4 protein] | 16012755 |
| C059514 | resveratrol | [resveratrol analog co-treated with Dietary Fats] results in increased expression of SIRT1 mRNA | 24759758 |
| C059514 | resveratrol | [2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate co-treated with resveratrol] affects the expression of SIRT1 protein | 24885036 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]]" | 25665036|2645094 |
| C059514 | resveratrol | "6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]" | 20370652 |
| C059514 | resveratrol | "[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol" | 23124026 |
| C059514 | resveratrol | Acetaminophen inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 25956474 |
| C059514 | resveratrol | Ethanol promotes the reaction [resveratrol results in increased expression of SIRT1 protein] | 18755807 |
| C059514 | resveratrol | [MIR34A mRNA results in decreased expression of SIRT1 protein] which results in decreased susceptibility to resveratrol | 24073240 |
| C059514 | resveratrol | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 23735732 |
| C059514 | resveratrol | PRKAA1 gene mutant form inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 25761413 |
| C059514 | resveratrol | PRKAA1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]] | 23090186 |
| C059514 | resveratrol | PRKAA2 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]] | 23090186 |
| C059514 | resveratrol | resveratrol affects the expression of SIRT1 protein | 24254769 |
| C059514 | resveratrol | [resveratrol co-treated with Dietary Fats] results in increased expression of SIRT1 mRNA | 24985011 |
| C059514 | resveratrol | "[resveratrol co-treated with enterotoxin B, staphylococcal] results in increased expression of SIRT1 mRNA" | 22646800 |
| C059514 | resveratrol | [resveratrol co-treated with Ethanol] results in increased expression of SIRT1 mRNA | 18755807 |
| C059514 | resveratrol | [resveratrol co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA | 21113404 |
| C059514 | resveratrol | resveratrol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein] | 24254769 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 mRNA] | 25707573 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Bleomycin results in decreased expression of SIRT1 protein] | 25707573 |
| C059514 | resveratrol | resveratrol inhibits the reaction [CCAR2 protein binds to and results in decreased activity of SIRT1 protein] | 24252177 |
| C059514 | resveratrol | [resveratrol inhibits the reaction [CCAR2 protein binds to and results in decreased activity of SIRT1 protein]] which results in increased activity of SIRT1 protein | 24252177 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein] | 21593185 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 mRNA] | 24548422 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 protein] | 19940103 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 24812660 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein] | 25665036|2645094 |
| C059514 | resveratrol | "resveratrol inhibits the reaction [enterotoxin B, staphylococcal results in decreased expression of SIRT1 protein]" | 22646800 |
| C059514 | resveratrol | resveratrol inhibits the reaction [ERCC6 gene mutant form results in decreased expression of SIRT1 protein] | 25440059 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein] | 18755807 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein] | 18755807 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 18755807 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 23090186 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] | 23293585 |
| C059514 | resveratrol | "resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of SIRT1 mRNA]" | 23625030 |
| C059514 | resveratrol | "resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SIRT1 protein]" | 23625030|2705221 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased activity of SIRT1 protein] | 19279313 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein] | 22952890|2397330 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA] | 22687363 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein] | 22058332 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 24889822 |
| C059514 | resveratrol | resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 mRNA] | 26708779 |
| C059514 | resveratrol | resveratrol promotes the reaction [Paraquat results in increased expression of SIRT1 protein] | 26708779 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein results in decreased acetylation of PPARGC1A protein] | 17581637 |
| C059514 | resveratrol | resveratrol promotes the reaction [SIRT1 protein results in increased acetylation of TRP53 protein] | 19819963 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 protein | 17112576|1758163 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of BAD protein] | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased acetylation of PPARGC1A protein | 18755807 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein | 21321189 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein | 21321189 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein | 21321189 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased cleavage of and results in decreased activity of CASP1 protein | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased cleavage of and results in decreased activity of CASP3 protein | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased localization of FOXO3 protein | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of DLG1 mRNA | 21232033 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of PPARGC1A protein | 20561979 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein | 20370652 |
| C059514 | resveratrol | [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein | 20370652 |
| C059514 | resveratrol | resveratrol results in increased expression of and results in increased activity of SIRT1 protein | 18755807 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 | 21224254 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 mRNA | 18755807|2264680 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 18930334|1994010 |
| C059514 | resveratrol | resveratrol results in increased localization of and results in increased activity of SIRT1 protein | 20370652 |
| C059514 | resveratrol | [resveratrol results in increased localization of and results in increased activity of SIRT1 protein] which results in decreased susceptibility to Glucose | 20370652 |
| C059514 | resveratrol | resveratrol results in increased phosphorylation of SIRT1 protein | 24296261 |
| C059514 | resveratrol | SIRT1 gene mutant form inhibits the reaction [resveratrol results in decreased acetylation of JUN protein] | 24073240 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]] | 21593185 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]] | 21593185 |
| C059514 | resveratrol | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]]" | 23625030 |
| C059514 | resveratrol | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]" | 23625030 |
| C059514 | resveratrol | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 protein]]" | 23625030 |
| C059514 | resveratrol | "SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]]" | 23625030 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [ZMPSTE24 gene mutant form results in increased expression of CAT protein]] | 23217256 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [ZMPSTE24 gene mutant form results in increased expression of GADD45A protein]] | 23217256 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in decreased expression of EP300 protein] | 23297412 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased expression of BIRC5 protein] | 22137261 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in decreased phosphorylation of AKT1 protein] | 22137261 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased cleavage of CASP3 protein] | 22137261 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased cleavage of CASP9 protein] | 22137261 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol results in increased expression of MYH6 mRNA] | 18192211 |
| C059514 | resveratrol | SIRT1 protein affects the susceptibility to resveratrol | 23090186|2478261 |
| C059514 | resveratrol | [SIRT1 protein co-treated with resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein] | 23090186 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]] | 22069489 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL1B protein]] | 22069489 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 protein]] | 22069489 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]] | 22069489 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of ACADM mRNA] | 19934007 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of ESRRA mRNA] | 19934007 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol results in increased expression of PPARGC1A mRNA] | 19934007 |
| C059514 | resveratrol | SIRT1 protein results in increased susceptibility to resveratrol | 22069489|2362503 |
| C059514 | resveratrol | SIRT1 results in increased susceptibility to resveratrol | 21593185 |
| C059514 | resveratrol | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]] | 25665036|2645094 |
| C059514 | resveratrol | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 23973301 |
| C059514 | resveratrol | [Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 24252177 |
| C059514 | resveratrol | wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 22952890 |
| C059514 | resveratrol | "(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]]" | 23211629 |
| C059514 | resveratrol | bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]] | 24889822 |
| C059514 | resveratrol | Niacinamide inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] | 23211629 |
| C059514 | resveratrol | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 mRNA] | 23891692 |
| C059514 | resveratrol | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 23891692 |
| C059514 | resveratrol | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA] | 18420994 |
| C059514 | resveratrol | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 25108154 |
| C059514 | resveratrol | resveratrol binds to and results in increased activity of SIRT1 protein | 18239056|2296814 |
| C059514 | resveratrol | [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA | 17583434 |
| C059514 | resveratrol | resveratrol inhibits the reaction [AGT protein promotes the reaction [SIRT1 protein binds to FOXO1 protein]] | 26955731 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] | 25833014 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 mRNA] | 22284404 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SIRT1 protein] | 22284404 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dietary Fats results in decreased activity of SIRT1 protein] | 21632075 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 25849131 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 protein] | 25228148|2568656 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA] | 18793633 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 mRNA] | 26488877 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Fructose results in decreased expression of SIRT1 protein] | 25108154 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310|2689108 |
| C059514 | resveratrol | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of SIRT1 mRNA] | 25238689 |
| C059514 | resveratrol | resveratrol inhibits the reaction [High Fructose Corn Syrup results in decreased expression of SIRT1 protein] | 25238689 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein] | 23891692 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 mRNA] | 25352008 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 protein] | 25352008 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA] | 22968147 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 mRNA] | 22733486|2474075 |
| C059514 | resveratrol | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 23792339|2474075 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA] | 24289075 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 protein] | 24289075 |
| C059514 | resveratrol | resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein] | 23211629 |
| C059514 | resveratrol | resveratrol promotes the reaction [Tobacco Smoke Pollution results in increased expression of SIRT1 mRNA] | 18424637 |
| C059514 | resveratrol | resveratrol results in decreased expression of SIRT1 protein | 20195491|2097282 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 protein | 18077353|1900834 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased acetylation of PPARGC1A protein | 23422569 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of CASP3 protein modified form | 23479127 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in increased acetylation of and results in decreased degradation of FOXO1 protein | 18077353 |
| C059514 | resveratrol | resveratrol results in increased expression of and results in increased activity of SIRT1 protein | 24395567 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 | 23790948 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 mRNA | 17583434|2171568 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 17583434|2171568 |
| C059514 | resveratrol | SIRT1 mutant form affects the reaction [resveratrol results in decreased expression of GH1 mRNA] | 23292070 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]] | 23292070 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in decreased expression of POU1F1 protein] | 23292070 |
| C059514 | resveratrol | SIRT1 mutant form inhibits the reaction [resveratrol results in decreased secretion of GH1 protein] | 23292070 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CTGF protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of FN1 protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of HIF1A protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of TGFB1 protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of VEGFA protein]] | 26891083 |
| C059514 | resveratrol | SIRT1 protein affects the susceptibility to resveratrol | 20651248 |
| C059514 | resveratrol | "SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST mRNA]]" | 26307266 |
| C059514 | resveratrol | "SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [2,2',3,5',6-pentachlorobiphenyl results in increased expression of REST protein]]" | 26307266 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]] | 24889822 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]] | 24889822 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein]] | 24889822 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Hydrogen Peroxide]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP3 protein]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP7 protein]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NOS2 mRNA]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]] | 18424637 |
| C059514 | resveratrol | SIRT1 protein promotes the reaction [resveratrol promotes the reaction [FOXO1 protein binds to RAB7A promoter]] | 24889822 |
| C059514 | resveratrol | SIRT1 protein results in increased susceptibility to resveratrol | 22561310|2488982 |
| C059514 | resveratrol | sirtinol inhibits the reaction [resveratrol results in increased expression of and results in increased activity of SIRT1 protein] | 24395567 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 mRNA | 17037214|1785173 |
| C059514 | resveratrol | resveratrol results in increased expression of SIRT1 protein | 23065251 |
| C059514 | resveratrol | resveratrol analog results in increased activity of SIRT1 protein | 24759758 |
| C059514 | resveratrol | resveratrol binds to and results in increased activity of SIRT1 protein | 17885668|1819221 |
| C059514 | resveratrol | [resveratrol co-treated with IL1B protein] promotes the reaction [SIRT1 protein binds to SCX protein] | 22936809 |
| C059514 | resveratrol | resveratrol inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in decreased activity of SIRT1 protein] | 19008341 |
| C059514 | resveratrol | resveratrol inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein] | 22936809 |
| C059514 | resveratrol | [resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]] inhibits the reaction [Niacinamide results in increased expression of PPARG] | 22539994 |
| C059514 | resveratrol | [resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]] which results in decreased activity of NCOR1 protein | 22539994 |
| C059514 | resveratrol | resveratrol results in decreased activity of SIRT1 protein | 21205922 |
| C059514 | resveratrol | [resveratrol results in decreased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP9] | 24429678 |
| C059514 | resveratrol | [resveratrol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to IL1B protein | 24429678 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 | 21593185 |
| C059514 | resveratrol | resveratrol results in increased activity of SIRT1 protein | 17041012|1745244 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Colforsin results in increased expression of CRTC2 protein modified form] | 18849969 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased abundance of Nitrites] | 19008341 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased acetylation of RELA protein] | 19008341 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of NOS2 mRNA] | 19008341 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased expression of NOS2 protein] | 19008341 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] | 19008341 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which affects the activity of NCOR1 protein | 22539994 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of PPARG protein | 22539994 |
| C059514 | resveratrol | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of AGTR1 | 18420994 |
| C059514 | resveratrol | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [TGFB1 protein results in increased acetylation of SMAD3 protein]] | 20651248 |
| C059514 | resveratrol | SIRT1 protein affects the susceptibility to resveratrol | 22539994 |
| C499731 | resveratrol-4'-O-glucuronide | resveratrol-4'-O-glucuronide results in increased expression of SIRT1 mRNA | 22945685 |
| C089730 | rosiglitazone | [rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of SIRT1 protein | 29288687 |
| C089730 | rosiglitazone | [rosiglitazone co-treated with Oxygen deficiency] results in increased expression of SIRT1 protein | 21113404 |
| C089730 | rosiglitazone | rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 20007851 |
| C089730 | rosiglitazone | rosiglitazone inhibits the reaction [Oxygen deficiency results in decreased expression of SIRT1 protein] | 21113404 |
| D012402 | Rotenone | resveratrol inhibits the reaction [Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein]] | 25991017 |
| D012402 | Rotenone | resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 mRNA] | 25991017 |
| D012402 | Rotenone | resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein] | 25991017 |
| D012402 | Rotenone | Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein] | 25991017 |
| D012402 | Rotenone | Rotenone results in decreased expression of SIRT1 mRNA | 25991017 |
| D012402 | Rotenone | Rotenone results in decreased expression of SIRT1 protein | 25991017 |
| D012402 | Rotenone | Rotenone results in decreased expression of SIRT1 protein | 18538940 |
| D012402 | Rotenone | Rotenone results in increased expression of SIRT1 protein | 18538940 |
| C513635 | S-2-pentyl-4-pentynoic hydroxamic acid | S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SIRT1 mRNA | 21427059 |
| D020156 | Salicylic Acid | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid | 25108154 |
| C568740 | salvianolic acid | salvianolic acid results in increased expression of SIRT1 protein | 23993977 |
| C568740 | salvianolic acid | salvianolic acid results in increased expression of SIRT1 mRNA | 23993977 |
| C568740 | salvianolic acid | salvianolic acid results in increased expression of SIRT1 protein | 23993977 |
| C066201 | salvianolic acid A | Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 mRNA] | 23993977 |
| C066201 | salvianolic acid A | Plant Extracts promotes the reaction [salvianolic acid A results in increased expression of SIRT1 protein] | 23993977 |
| C066201 | salvianolic acid A | salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 mRNA] | 23993977 |
| C066201 | salvianolic acid A | salvianolic acid A promotes the reaction [Plant Extracts results in increased expression of SIRT1 protein] | 23993977 |
| C076944 | salvianolic acid B | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 27989594 |
| C076944 | salvianolic acid B | salvianolic acid B results in increased expression of SIRT1 protein | 24769256|2798959 |
| C076944 | salvianolic acid B | SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] | 27989594 |
| C076944 | salvianolic acid B | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA] | 24769256 |
| C076944 | salvianolic acid B | salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 24769256|2798959 |
| C076944 | salvianolic acid B | SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]] | 27989594 |
| C018381 | salvin | Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]] | 24557422 |
| C018381 | salvin | salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| C018381 | salvin | salvin results in increased expression of SIRT1 mRNA | 24557422 |
| C018381 | salvin | salvin results in increased expression of SIRT1 protein | 24557422 |
| C018381 | salvin | SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein] | 24557422 |
| D012503 | Saponins | Saponins inhibits the reaction [Galactose results in decreased expression of SIRT1 protein] | 25892055 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [Hydrogen Peroxide affects the localization of SIRT1 protein] | 25512378 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]] | 19303870 |
| C093642 | SB 203580 | SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]] | 19303870 |
| D012643 | Selenium | Selenium results in decreased expression of SIRT1 mRNA | 19244175 |
| D012822 | Silicon Dioxide | Silicon Dioxide results in increased expression of SIRT1 mRNA | 25351596 |
| D012834 | Silver | Silver results in increased expression of SIRT1 mRNA | 26014281 |
| D026082 | Singlet Oxygen | Singlet Oxygen results in increased expression of SIRT1 mRNA | 22860104 |
| D026082 | Singlet Oxygen | Singlet Oxygen results in increased expression of SIRT1 protein | 22860104 |
| D020123 | Sirolimus | Aspirin inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D020123 | Sirolimus | cilostazol inhibits the reaction [Sirolimus results in decreased expression of SIRT1 protein] | 19520256 |
| D020123 | Sirolimus | [(+)-JQ1 compound co-treated with Sirolimus] results in decreased expression of SIRT1 protein | 25307878 |
| D020123 | Sirolimus | Sirolimus results in decreased expression of SIRT1 protein | 19520256|2530787 |
| D020123 | Sirolimus | Sirolimus inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] | 22561310 |
| D020123 | Sirolimus | Sirolimus results in increased expression of SIRT1 protein | 22561310 |
| D020123 | Sirolimus | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]] | 22561310 |
| D020123 | Sirolimus | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]] | 22561310 |
| D020123 | Sirolimus | SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of GLB1 protein]] | 22561310 |
| D020123 | Sirolimus | SIRT1 protein results in increased susceptibility to Sirolimus | 22561310 |
| C439060 | sirtinol | sirtinol inhibits the reaction [Glucose results in increased expression of SIRT1 protein] | 22284404 |
| C439060 | sirtinol | sirtinol analog results in decreased activity of SIRT1 protein | 16302818 |
| C439060 | sirtinol | sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 mRNA] | 23881456 |
| C439060 | sirtinol | sirtinol inhibits the reaction [cudraflavone B results in increased expression of SIRT1 protein] | 23881456 |
| C439060 | sirtinol | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| C439060 | sirtinol | sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]] | 25159133 |
| C439060 | sirtinol | sirtinol inhibits the reaction [[resveratrol co-treated with TNF protein] results in increased expression of SIRT1 protein] | 23257246 |
| C439060 | sirtinol | sirtinol inhibits the reaction [SIRT1 protein binds to SHC1 promoter] | 21778425 |
| C439060 | sirtinol | sirtinol results in decreased activity of SIRT1 protein | 16302818|1928822 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased expression of FBXO32 mRNA | 22146233 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Plant Extracts | 22563892 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 20610621|2069789 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide | 18681908 |
| C439060 | sirtinol | [cobaltous chloride co-treated with sirtinol] results in decreased expression of SIRT1 protein | 22275802 |
| C439060 | sirtinol | sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] | 24254769 |
| C439060 | sirtinol | sirtinol inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] | 24254769 |
| C439060 | sirtinol | sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 28477916 |
| C439060 | sirtinol | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in decreased activity of SIRT1 protein]] | 25665036|2645094 |
| C439060 | sirtinol | sirtinol inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 23973301 |
| C439060 | sirtinol | sirtinol results in decreased activity of SIRT1 protein | 20370652 |
| C439060 | sirtinol | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Glucose | 20370652 |
| C439060 | sirtinol | sirtinol inhibits the reaction [cobaltous chloride results in increased expression of SIRT1 protein] | 22669716 |
| C439060 | sirtinol | sirtinol inhibits the reaction [resveratrol results in increased expression of and results in increased activity of SIRT1 protein] | 24395567 |
| C439060 | sirtinol | sirtinol results in decreased activity of SIRT1 protein | 23479127 |
| C439060 | sirtinol | sirtinol binds to and results in decreased activity of SIRT1 protein | 18849969 |
| C439060 | sirtinol | [sirtinol binds to and results in decreased activity of SIRT1 protein] promotes the reaction [GCG protein results in increased acetylation of CRTC2 protein] | 18849969 |
| C439060 | sirtinol | sirtinol results in decreased activity of SIRT1 protein | 17041012|1765272 |
| D012906 | Smoke | SIRT1 protein affects the reaction [Smoke results in increased secretion of CXCL8 protein] | 17041012 |
| D012906 | Smoke | SIRT1 protein affects the reaction [Smoke results in increased secretion of TNF protein] | 17041012 |
| D012906 | Smoke | Smoke inhibits the reaction [SIRT1 protein binds to RELA protein] | 17041012 |
| D012906 | Smoke | Smoke results in decreased expression of and results in decreased activity of SIRT1 protein | 17041012 |
| C021315 | S-nitrosocysteine | S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased acetylation of TP53 protein] | 24451382 |
| C021315 | S-nitrosocysteine | S-nitrosocysteine inhibits the reaction [SIRT1 protein results in decreased cleavage of CASP3 protein] | 24451382 |
| C017947 | sodium arsenite | INS protein inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein] | 25982963 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of SIRT1 protein | 25982963 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of SIRT1 mRNA | 17879257 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of SIRT1 mRNA | 25610880 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of SIRT1 protein | 25610880 |
| C017947 | sodium arsenite | sodium arsenite results in increased expression of SIRT1 mRNA | 19822182 |
| D012969 | Sodium Fluoride | Sodium Fluoride results in increased expression of SIRT1 mRNA | 24296261 |
| D012969 | Sodium Fluoride | Sodium Fluoride results in increased phosphorylation of and results in increased activity of SIRT1 protein | 24296261 |
| D012969 | Sodium Fluoride | Sodium Fluoride results in increased phosphorylation of and results in increased expression of SIRT1 protein | 24296261 |
| C444426 | splitomicin | splitomicin results in decreased activity of SIRT1 protein | 18482975|2097800 |
| C444426 | splitomicin | "[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein]" | 18482975 |
| C444426 | splitomicin | [splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein] | 18482975 |
| C444426 | splitomicin | splitomicin results in decreased expression of SIRT1 mRNA | 25447406 |
| C444426 | splitomicin | splitomicin results in decreased activity of SIRT1 protein | 23525482 |
| C525422 | SRT1720 | SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein] | 26712469 |
| C525422 | SRT1720 | SRT1720 results in decreased activity of SIRT1 protein | 24429678 |
| C525422 | SRT1720 | SRT1720 results in increased activity of SIRT1 protein | 20844277 |
| C525422 | SRT1720 | SRT1720 results in increased expression of SIRT1 protein | 26873845 |
| C525422 | SRT1720 | SRT1720 results in increased activity of SIRT1 protein | 24633890 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in decreased expression of CRTC2 protein modified form | 18849969 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in increased abundance of Glucose | 21212096 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of ACACA mRNA | 21212096 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of HMGCR mRNA | 21212096 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of PPARGC1B mRNA | 21212096 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] which results in increased expression of SREBF1 mRNA | 21212096 |
| C525422 | SRT1720 | [SRT1720 results in decreased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP9] | 24429678 |
| C525422 | SRT1720 | [SRT1720 results in decreased activity of SIRT1 protein] which results in decreased susceptibility to IL1B protein | 24429678 |
| C525422 | SRT1720 | SRT1720 results in increased activity of SIRT1 protein | 18849969|2121209 |
| C525422 | SRT1720 | [SRT1720 results in increased activity of SIRT1 protein] inhibits the reaction [GCG protein results in increased expression of CRTC2 protein modified form] | 18849969 |
| C518404 | stannous mesoporphyrin | stannous mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin results in increased expression of SIRT1 protein] | 26026874 |
| C518404 | stannous mesoporphyrin | stannous mesoporphyrin inhibits the reaction [[SIRT1 gene mutant form co-treated with cobaltiprotoporphyrin] results in increased expression of PTPN1 protein] | 26026874 |
| D019311 | Staurosporine | [Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein | 23293585 |
| D019311 | Staurosporine | resveratrol inhibits the reaction [[Hydrogen Peroxide co-treated with Staurosporine] results in decreased expression of SIRT1 protein] | 23293585 |
| C012042 | steviol | steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] | 25554529 |
| C012043 | stevioside | stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] | 25554529 |
| D013311 | Streptozocin | AICA ribonucleotide inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein] | 22058332 |
| D013311 | Streptozocin | Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 23859249 |
| D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein] | 22058332 |
| D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 24889822 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2] | 22744176 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] | 21778425 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN1A] | 22744176 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1] | 22744176 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA] | 21778425 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 mRNA] | 21778425 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of SHC1 protein] | 21778425 |
| D013311 | Streptozocin | SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53] | 22744176 |
| D013311 | Streptozocin | Streptozocin results in decreased activity of SIRT1 protein | 22058332 |
| D013311 | Streptozocin | Streptozocin results in decreased expression of SIRT1 protein | 21778425|2385924 |
| D013311 | Streptozocin | Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 25301743 |
| D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 mRNA] | 22733486|2474075 |
| D013311 | Streptozocin | resveratrol inhibits the reaction [Streptozocin results in decreased expression of SIRT1 protein] | 23792339|2474075 |
| D013311 | Streptozocin | Streptozocin results in decreased expression of SIRT1 mRNA | 22733486|2474075 |
| D013311 | Streptozocin | Streptozocin results in decreased expression of SIRT1 protein | 23792339|2474075 |
| D013467 | Sulindac | Sulindac results in increased expression of SIRT1 mRNA | 11906190 |
| D013481 | Superoxides | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] | 18424637 |
| D013498 | Suramin | Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] | 23217256 |
| D013498 | Suramin | Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] | 18482975 |
| D013498 | Suramin | [Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 24252177 |
| D013498 | Suramin | Suramin results in decreased activity of SIRT1 protein | 24252177 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in decreased expression of SREBF1 mRNA] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A mRNA] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of CPT1A protein] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PCK1 mRNA] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in increased expression of PDK4 mRNA] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the susceptibility to Triiodothyronine | 23209300 |
| D014284 | Triiodothyronine | Triiodothyronine results in increased expression of SIRT1 mRNA | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in decreased acetylation of PPARGC1A protein] | 23209300 |
| D014284 | Triiodothyronine | SIRT1 protein affects the reaction [Triiodothyronine results in decreased activity of SREBF1 protein] | 23209300 |
| D014284 | Triiodothyronine | Triiodothyronine promotes the reaction [SIRT1 protein binds to CPT1A promoter] | 23209300 |
| D013654 | Taurine | Taurine inhibits the reaction [arsenite results in decreased expression of SIRT1 mRNA] | 23744399 |
| D013654 | Taurine | Taurine inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] | 26930420 |
| C045037 | testosterone-3-carboxymethyloxime-bovine serum albumin conjugate | testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of SIRT1 mRNA | 20189893 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of SIRT1 protein | 20876576 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of SIRT1 mRNA | 21570461 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SIRT1 mRNA | 25613284 |
| D008063 | Thioctic Acid | Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | 22327056 |
| D008063 | Thioctic Acid | Thioctic Acid results in increased expression of SIRT1 protein | 22327056 |
| D008063 | Thioctic Acid | [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein | 22327056 |
| D008063 | Thioctic Acid | [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein | 22327056 |
| D013974 | Thyroxine | Thyroxine results in increased expression of SIRT1 protein | 18204789 |
| C003466 | thymoquinone | thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of SIRT1 protein] | 27688165 |
| C003466 | thymoquinone | thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein] | 27688165 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of SIRT1 | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of HMOX1 mRNA] | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of NQO1 mRNA] | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SOD2 mRNA] | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SOD2 protein] | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal] | 24633890 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Malondialdehyde] | 24633890 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of SIRT1 | 24633890 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in decreased expression of SIRT1 protein | 27319396 |
| D014028 | Tobacco Smoke Pollution | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA] | 24289075 |
| D014028 | Tobacco Smoke Pollution | resveratrol inhibits the reaction [[Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 protein] | 24289075 |
| D014028 | Tobacco Smoke Pollution | resveratrol promotes the reaction [Tobacco Smoke Pollution results in increased expression of SIRT1 mRNA] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Hydrogen Peroxide]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP3 protein]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP7 protein]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NOS2 mRNA]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]] | 18424637 |
| D014028 | Tobacco Smoke Pollution | [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 mRNA | 24289075 |
| D014028 | Tobacco Smoke Pollution | [Tobacco Smoke Pollution co-treated with Lipopolysaccharides] results in decreased expression of SIRT1 protein | 24289075 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution results in increased expression of SIRT1 mRNA | 18424637 |
| C505532 | trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside | "SIRT1 mutant form inhibits the reaction [trans-3,5,4'-trihydroxystilbene-4'-O-beta-D-glucopyranoside results in increased expression of SOD2]" | 23042952 |
| C012589 | trichostatin A | [Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein] | 15788402 |
| D014280 | Triglycerides | PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides]] | 18482975 |
| D014280 | Triglycerides | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides] | 18482975 |
| D014280 | Triglycerides | SIRT1 protein inhibits the reaction [Glucose results in increased abundance of Triglycerides] | 18482975 |
| D014280 | Triglycerides | SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides] | 18482975 |
| D014302 | Trinitrobenzenesulfonic Acid | Trinitrobenzenesulfonic Acid results in decreased expression of SIRT1 protein | 24782617 |
| C031324 | tris(chloroethyl)phosphate | tris(chloroethyl)phosphate results in increased expression of SIRT1 mRNA | 26378621 |
| C031324 | tris(chloroethyl)phosphate | tris(chloroethyl)phosphate results in increased expression of SIRT1 protein | 26378621 |
| C002802 | tungsten carbide | [tungsten carbide co-treated with Cobalt] results in decreased expression of SIRT1 mRNA | 18078969 |
| C113580 | U 0126 | U 0126 results in decreased expression of SIRT1 protein | 24894820 |
| D014520 | Urethane | Urethane results in increased expression of SIRT1 mRNA | 28818685 |
| C003747 | urushiol | urushiol analog results in decreased activity of SIRT1 protein | 24998427 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of SIRT1 mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of SIRT1 mRNA | 23179753|2718838 |
| D014635 | Valproic Acid | Valproic Acid results in decreased methylation of SIRT1 gene | 28853863 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of SIRT1 mRNA | 15799026|1913645 |
| D001335 | Vehicle Emissions | Vehicle Emissions results in decreased methylation of SIRT1 gene | 25560391 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein] | 22539994 |
| D009536 | Niacinamide | Niacinamide results in decreased expression of SIRT1 protein | 22539994 |
| D009536 | Niacinamide | resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]] | 22539994 |
| D009536 | Niacinamide | resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein] | 22539994 |
| D009536 | Niacinamide | [Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein | 26712469 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]] | 25472572 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 19928762 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]] | 24557422 |
| D009536 | Niacinamide | Niacinamide promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein] | 24557422 |
| D009536 | Niacinamide | Niacinamide results in decreased activity of SIRT1 protein | 17103016|1907108 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] | 18681908 |
| D009536 | Niacinamide | Niacinamide results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] | 18482975 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased expression of DEFB4A mRNA | 24894820 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased expression of CXCL8 mRNA | 24894820 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of EIF4EBP1 protein | 20169165 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of RPS6 protein | 20169165 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide | 18681908 |
| D009536 | Niacinamide | Niacinamide results in decreased expression of SIRT1 mRNA | 21745208 |
| D009536 | Niacinamide | Niacinamide results in decreased expression of SIRT1 protein | 19928762 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [SIRT1 protein results in increased activity of FOXO4 protein] | 16012755 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [[SIRT1 protein binds to UCP2 promoter] which results in decreased expression of UCP2 mRNA] | 16366736 |
| D009536 | Niacinamide | Niacinamide results in decreased activity of SIRT1 protein | 16366736 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [SIRT1 protein results in increased expression of PPARGC1A mRNA] | 23891692 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased expression of DLG1 mRNA | 21232033 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 23735732 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein] | 19288225 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [FOXO1 protein binds to SIRT1 protein] | 20181797 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [resveratrol promotes the reaction [Pilocarpine results in increased expression of SIRT1 protein]] | 23211629 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 mRNA] | 23891692 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] | 23891692 |
| D009536 | Niacinamide | Niacinamide inhibits the reaction [SIRT1 protein results in decreased abundance of NAD] | 19288225 |
| D009536 | Niacinamide | Niacinamide results in decreased activity of SIRT1 protein | 16366736|1928822 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol] | 21212096 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Glucose] | 21212096 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of ACACA mRNA] | 21212096 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased expression of HMGCR mRNA] | 21212096 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA] | 18420994 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to AICA ribonucleotide | 25108154 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Fructose | 21212096 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin | 25108154 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol | 25108154 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid | 25108154 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein | 23422569 |
| D009536 | Niacinamide | [Niacinamide results in decreased activity of SIRT1 protein] which results in increased expression of AGTR1 mRNA | 18420994 |
| D009536 | Niacinamide | Niacinamide results in decreased expression of SIRT1 protein | 22561310 |
| D009536 | Niacinamide | Niacinamide results in decreased expression of SIRT1 mRNA | 17851734 |
| D009536 | Niacinamide | Niacinamide binds to and results in decreased activity of SIRT1 protein | 18849969 |
| D009536 | Niacinamide | [Niacinamide co-treated with trichostatin A] inhibits the reaction [FOXO1 protein binds to SIRT1 protein] | 15788402 |
| D009536 | Niacinamide | Niacinamide results in decreased activity of SIRT1 protein | 17452443|1842099 |
| D009536 | Niacinamide | [resveratrol promotes the reaction [SIRT1 protein binds to RUNX2 protein]] inhibits the reaction [Niacinamide results in increased expression of PPARG] | 22539994 |
| D014810 | Vitamin E | Vitamin E results in decreased expression of SIRT1 mRNA | 19244175 |
| C009687 | wortmannin | wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] | 18298901 |
| C009687 | wortmannin | wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]] | 22952890 |
| C009687 | wortmannin | [wortmannin co-treated with IL1B protein] promotes the reaction [SIRT1 protein binds to SCX protein] | 22936809 |
| C009687 | wortmannin | wortmannin inhibits the reaction [IL1B protein results in decreased expression of SIRT1 protein] | 22936809 |
| D015032 | Zinc | [PCI 5002 co-treated with Zinc] results in increased expression of SIRT1 mRNA | 18593933 |
| D015034 | Zinc Oxide | Zinc Oxide affects the expression of SIRT1 mRNA | 28648595 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | - | IEA | - |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | - | IEA | - |
| GO:0002039 | p53 binding | - | IPI | 11672523 |
| GO:0003714 | transcription corepressor activity | - | IDA | 12535671 |
| GO:0003714 | transcription corepressor activity | - | ISS | - |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | NOT | TAS | 17456799 |
| GO:0004407 | histone deacetylase activity | - | EXP | 18485871 |
| GO:0004407 | histone deacetylase activity | - | IDA | 20027304 |
| GO:0005515 | protein binding | - | IPI | 11672523 12006491 12535671 14976264 15126506 15152190 15175761 15205477 15220471 15632193 15692560 16892051 16998810 17172643 17334224 17612497 17680780 17901049 17936707 17964266 18004385 18203716 18235501 18235502 18296641 18485871 19047049 19188449 19236849 19343720 19478080 19680552 19690166 19934257 19934264 20169165 20375098 20439735 20670893 20817729 21030595 21081649 21212262 21241768 21245319 21471201 21555002 21698133 21775285 21807113 21890893 21909281 21947282 21968188 22094255 22169038 22190034 22510882 22863012 23382074 24681097 25661920 25751424 |
| GO:0008022 | protein C-terminus binding | - | IPI | 18203716 |
| GO:0008134 | transcription factor binding | - | IPI | 20955178 23382074 |
| GO:0017136 | NAD-dependent histone deacetylase activity | - | IDA | 12006491 15469825 16959573 |
| GO:0019213 | deacetylase activity | - | IDA | 18203716 |
| GO:0019899 | enzyme binding | - | IPI | 23382074 |
| GO:0033558 | protein deacetylase activity | - | IDA | 19934257 20027304 21807113 23056314 |
| GO:0033558 | protein deacetylase activity | - | IMP | 20424141 20670893 |
| GO:0034979 | NAD-dependent protein deacetylase activity | - | IDA | 20955178 21775285 |
| GO:0034979 | NAD-dependent protein deacetylase activity | - | IMP | 11672523 |
| GO:0034979 | NAD-dependent protein deacetylase activity | - | TAS | - |
| GO:0035257 | nuclear hormone receptor binding | - | IPI | 24043310 |
| GO:0042393 | histone binding | - | IPI | 15469825 22956909 |
| GO:0042802 | identical protein binding | - | IPI | 15469825 |
| GO:0043398 | HLH domain binding | - | IPI | 12535671 |
| GO:0043425 | bHLH transcription factor binding | - | IPI | 12535671 21807113 |
| GO:0046872 | metal ion binding | - | IEA | - |
| GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | - | ISS | - |
| GO:0051019 | mitogen-activated protein kinase binding | - | IPI | 20027304 |
| GO:0070403 | NAD+ binding | - | IEA | - |
| GO:1990254 | keratin filament binding | - | IPI | 23382074 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000012 | single strand break repair | - | IMP | 20097625 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | - | IDA | 12535671 15692560 20955178 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | - | IMP | 21947282 |
| GO:0000183 | chromatin silencing at rDNA | - | IDA | 18485871 |
| GO:0000183 | chromatin silencing at rDNA | - | TAS | - |
| GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair | - | IMP | 21149730 |
| GO:0000731 | DNA synthesis involved in DNA repair | - | ISS | - |
| GO:0001525 | angiogenesis | - | IDA | 20620956 |
| GO:0001542 | ovulation from ovarian follicle | - | IEA | - |
| GO:0001678 | cellular glucose homeostasis | - | ISS | - |
| GO:0001934 | positive regulation of protein phosphorylation | - | ISS | - |
| GO:0001938 | positive regulation of endothelial cell proliferation | - | IMP | 20203304 |
| GO:0002821 | positive regulation of adaptive immune response | - | IDA | 21890893 |
| GO:0006325 | chromatin organization | - | IMP | 22956909 |
| GO:0006342 | chromatin silencing | - | TAS | 10381378 |
| GO:0006343 | establishment of chromatin silencing | - | IDA | 15469825 |
| GO:0006344 | maintenance of chromatin silencing | - | IMP | 15469825 |
| GO:0006346 | methylation-dependent chromatin silencing | - | TAS | 21947282 |
| GO:0006364 | rRNA processing | - | IEA | - |
| GO:0006366 | transcription by RNA polymerase II | - | IEA | - |
| GO:0006471 | protein ADP-ribosylation | NOT | TAS | 17456799 |
| GO:0006476 | protein deacetylation | - | IDA | 18203716 18662546 20027304 20955178 |
| GO:0006476 | protein deacetylation | - | IMP | 11672523 20424141 24824780 |
| GO:0006476 | protein deacetylation | - | TAS | 28386764 |
| GO:0006642 | triglyceride mobilization | - | ISS | - |
| GO:0006974 | cellular response to DNA damage stimulus | - | IDA | 18203716 |
| GO:0006979 | response to oxidative stress | - | IDA | 14976264 |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | - | IDA | 23960241 |
| GO:0007283 | spermatogenesis | - | IEA | - |
| GO:0007346 | regulation of mitotic cell cycle | - | IDA | 15692560 |
| GO:0007517 | muscle organ development | - | IEA | - |
| GO:0007569 | cell aging | - | TAS | 11672523 |
| GO:0008284 | positive regulation of cell proliferation | - | IMP | 21807113 |
| GO:0009267 | cellular response to starvation | - | ISS | - |
| GO:0010629 | negative regulation of gene expression | - | IMP | 17916362 20203304 |
| GO:0010875 | positive regulation of cholesterol efflux | - | ISS | - |
| GO:0010883 | regulation of lipid storage | - | ISS | - |
| GO:0010906 | regulation of glucose metabolic process | - | ISS | - |
| GO:0010934 | macrophage cytokine production | - | ISS | - |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | - | ISS | - |
| GO:0016032 | viral process | - | IEA | - |
| GO:0016239 | positive regulation of macroautophagy | - | IDA | 18296641 |
| GO:0016567 | protein ubiquitination | - | IDA | 21841822 |
| GO:0016567 | protein ubiquitination | - | IMP | 20203304 |
| GO:0016575 | histone deacetylation | - | IDA | 12006491 15469825 16079181 17172643 |
| GO:0018394 | peptidyl-lysine acetylation | - | IMP | 18004385 |
| GO:0030225 | macrophage differentiation | - | ISS | - |
| GO:0030308 | negative regulation of cell growth | - | IMP | 17505061 |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | - | ISS | - |
| GO:0031393 | negative regulation of prostaglandin biosynthetic process | - | ISS | - |
| GO:0031648 | protein destabilization | - | IDA | 20955178 |
| GO:0031648 | protein destabilization | - | ISS | - |
| GO:0031937 | positive regulation of chromatin silencing | - | IMP | 15469825 |
| GO:0032007 | negative regulation of TOR signaling | - | IMP | 20169165 |
| GO:0032071 | regulation of endodeoxyribonuclease activity | - | IMP | 19934257 |
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity | - | IDA | 15152190 |
| GO:0032868 | response to insulin | - | ISS | - |
| GO:0032922 | circadian regulation of gene expression | - | IMP | 18662546 |
| GO:0032922 | circadian regulation of gene expression | - | ISS | - |
| GO:0033158 | regulation of protein import into nucleus, translocation | - | IMP | 18203716 |
| GO:0033210 | leptin-mediated signaling pathway | - | ISS | - |
| GO:0034391 | regulation of smooth muscle cell apoptotic process | - | ISS | - |
| GO:0034983 | peptidyl-lysine deacetylation | - | IDA | 15469825 |
| GO:0035356 | cellular triglyceride homeostasis | - | ISS | - |
| GO:0035358 | regulation of peroxisome proliferator activated receptor signaling pathway | - | ISS | - |
| GO:0042127 | regulation of cell proliferation | - | IMP | 12006491 |
| GO:0042326 | negative regulation of phosphorylation | - | IMP | 17612497 |
| GO:0042542 | response to hydrogen peroxide | - | IDA | 19934257 |
| GO:0042595 | behavioral response to starvation | - | IEA | - |
| GO:0042632 | cholesterol homeostasis | - | ISS | - |
| GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | - | IMP | 20100829 |
| GO:0042981 | regulation of apoptotic process | - | IMP | 19934257 |
| GO:0043065 | positive regulation of apoptotic process | - | IDA | 15152190 |
| GO:0043065 | positive regulation of apoptotic process | - | IMP | 19047049 |
| GO:0043066 | negative regulation of apoptotic process | - | IMP | 16892051 21775285 |
| GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | - | IDA | 17680780 |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | - | IMP | 21841822 |
| GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | - | IMP | 19047049 |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | - | IDA | 11672523 20955178 |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity | - | IMP | 17505061 |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | - | IDA | 11672523 |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | - | IDA | 23960241 |
| GO:0044321 | response to leptin | - | ISS | - |
| GO:0045348 | positive regulation of MHC class II biosynthetic process | - | IDA | 21890893 |
| GO:0045599 | negative regulation of fat cell differentiation | - | ISS | - |
| GO:0045739 | positive regulation of DNA repair | - | IMP | 19934257 |
| GO:0045766 | positive regulation of angiogenesis | - | IDA | 23960241 25217442 |
| GO:0045766 | positive regulation of angiogenesis | - | IMP | 20424141 24048733 |
| GO:0045892 | negative regulation of transcription, DNA-templated | - | IDA | 11672523 20074560 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | - | IDA | 12837246 21807113 |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | - | IDA | 21241768 |
| GO:0050872 | white fat cell differentiation | - | ISS | - |
| GO:0051097 | negative regulation of helicase activity | - | IDA | 18203716 |
| GO:0051152 | positive regulation of smooth muscle cell differentiation | - | IEA | - |
| GO:0051574 | positive regulation of histone H3-K9 methylation | - | IMP | 22956909 |
| GO:0051898 | negative regulation of protein kinase B signaling | - | IMP | 21149730 |
| GO:0055089 | fatty acid homeostasis | - | ISS | - |
| GO:0060766 | negative regulation of androgen receptor signaling pathway | - | IMP | 17505061 |
| GO:0061647 | histone H3-K9 modification | - | IEA | - |
| GO:0070301 | cellular response to hydrogen peroxide | - | IDA | 20027304 |
| GO:0070857 | regulation of bile acid biosynthetic process | - | ISS | - |
| GO:0070914 | UV-damage excision repair | - | IMP | 20670893 |
| GO:0070932 | histone H3 deacetylation | - | IDA | 20027304 |
| GO:0070932 | histone H3 deacetylation | - | IMP | 17505061 |
| GO:0071356 | cellular response to tumor necrosis factor | - | IDA | 15152190 |
| GO:0071441 | negative regulation of histone H3-K14 acetylation | - | IMP | 17916362 |
| GO:0071456 | cellular response to hypoxia | - | IMP | 20620956 |
| GO:0071479 | cellular response to ionizing radiation | - | ISS | - |
| GO:0071900 | regulation of protein serine/threonine kinase activity | - | IMP | 20203304 |
| GO:0090335 | regulation of brown fat cell differentiation | - | ISS | - |
| GO:0090400 | stress-induced premature senescence | - | IMP | 17916362 |
| GO:1900034 | regulation of cellular response to heat | - | TAS | - |
| GO:1900113 | negative regulation of histone H3-K9 trimethylation | - | IEA | - |
| GO:1901215 | negative regulation of neuron death | - | IEA | - |
| GO:1901984 | negative regulation of protein acetylation | - | IMP | 17916362 20203304 |
| GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | - | ISS | 11672522 |
| GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | - | IMP | 17317627 |
| GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | - | IEA | - |
| GO:1904179 | positive regulation of adipose tissue development | - | ISS | - |
| GO:1990619 | histone H3-K9 deacetylation | - | IEA | - |
| GO:1990830 | cellular response to leukemia inhibitory factor | - | IEA | - |
| GO:2000111 | positive regulation of macrophage apoptotic process | - | ISS | - |
| GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | - | IDA | 20203304 |
| GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | - | IMP | 18687677 |
| GO:2000619 | negative regulation of histone H4-K16 acetylation | - | IMP | 17916362 |
| GO:2000655 | negative regulation of cellular response to testosterone stimulus | - | IMP | 17505061 |
| GO:2000757 | negative regulation of peptidyl-lysine acetylation | - | IDA | 20100829 |
| GO:2000773 | negative regulation of cellular senescence | - | IDA | 20203304 |
| GO:2000773 | negative regulation of cellular senescence | - | IMP | 20424141 |
| GO:2000774 | positive regulation of cellular senescence | - | IDA | 18687677 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000790 | nuclear chromatin | - | IDA | 17505061 22956909 |
| GO:0005634 | nucleus | - | IDA | 11672523 19934257 20027304 20167603 20955178 |
| GO:0005635 | nuclear envelope | - | IDA | 15469825 |
| GO:0005637 | nuclear inner membrane | - | IDA | 15469825 |
| GO:0005654 | nucleoplasm | - | IDA | 16079181 |
| GO:0005654 | nucleoplasm | - | TAS | - |
| GO:0005677 | chromatin silencing complex | - | IDA | 18485871 |
| GO:0005719 | nuclear euchromatin | - | IDA | 15469825 |
| GO:0005720 | nuclear heterochromatin | - | IDA | 15469825 |
| GO:0005730 | nucleolus | - | IDA | 15469825 |
| GO:0005730 | nucleolus | NOT | IDA | 16079181 |
| GO:0005737 | cytoplasm | - | IDA | 20027304 |
| GO:0005737 | cytoplasm | NOT | IDA | 15469825 |
| GO:0005739 | mitochondrion | - | IDA | - |
| GO:0005829 | cytosol | - | IDA | - |
| GO:0016605 | PML body | - | IDA | 12006491 |
| GO:0033553 | rDNA heterochromatin | - | IDA | 18485871 |
| GO:0035098 | ESC/E(Z) complex | colocalizes_with | IDA | 15684044 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-212165 | Epigenetic regulation of gene expression | TAS |
| R-HSA-212165 | Epigenetic regulation of gene expression | IEA |
| R-HSA-2262752 | Cellular responses to stress | TAS |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | TAS |
| R-HSA-3371556 | Cellular response to heat stress | TAS |
| R-HSA-400253 | Circadian Clock | IEA |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | TAS |
| R-HSA-427359 | SIRT1 negatively regulates rRNA expression | IEA |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | TAS |
| R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | IEA |
| R-HSA-74160 | Gene expression (Transcription) | TAS |
| R-HSA-74160 | Gene expression (Transcription) | IEA |
| R-HSA-8953897 | Cellular responses to external stimuli | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 29359516 | Seminal SIRT1 expression in infertile oligoasthenoteratozoospermic men with varicocoele. (2018 Mar) | Mostafa T | Andrology |
| 26298564 | Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. (2016 Feb) | Engler A | J Mol Med (Berl) |
| 29509781 | The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure. (2018) | Yanagisawa S | PLoS One |
| 17558024 | Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3. (2007 Aug 3) | Wu Z | J Biol Chem |
| 20054178 | Fat tissue and long life. (2008) | Bluher M | Obes Facts |
| 28123473 | Long-term nicotine exposure induces dysfunction of mouse endothelial progenitor cells. (2017 Jan) | Li W | Exp Ther Med |
| 27784320 | Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease. (2016 Oct 27) | Kato R | Respir Res |
| 23897750 | Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. (2013 Dec) | Paschalaki KE | Stem Cells |
| 27917437 | Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. (2017 Apr) | Sinha-Hikim I | Cell Tissue Res |
| 18424637 | Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. (2008 Jun) | Csiszar A | Am J Physiol Heart Circ Physiol |
| 26790673 | Resveratrol fails to affect cocaine conditioned place preference behavior, but alleviates anxiety-like behaviors in cocaine withdrawn rats. (2016 Apr) | Hu P | Psychopharmacology (Berl) |
| 22087257 | Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011) | Dong C | PLoS One |
| 26283591 | Resveratrol potentiates the effect of dexamethasone in rat model of acute lung inflammation. (2015 Sep) | Sadarani BN | Int Immunopharmacol |
| 22986747 | SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue. (2012 Nov 15) | Beane J | Cancer Res |
| 26672058 | Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study. (2016 Jul) | Pieters N | Environ Health Perspect |
| 19167483 | SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. (2009 Mar 15) | Zillikens MC | Free Radic Biol Med |
| 25894374 | K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. (2015 Sep) | Cheng D | Tumour Biol |
| 22978694 | Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. (2013 May 20) | Sundar IK | Antioxid Redox Signal |
| 24026667 | A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. (2013 Oct) | Luo C | Biogerontology |
| 24789730 | Nicotine inhibits the proliferation by upregulation of nitric oxide and increased HDAC1 in mouse neural stem cells. (2014 Sep) | Lee H | In Vitro Cell Dev Biol Anim |
| 24289075 | Resveratrol attenuates left ventricular remodeling in old rats with COPD induced by cigarette smoke exposure and LPS instillation. (2013 Dec) | Hu YX | Can J Physiol Pharmacol |
| 19756718 | Cardiovascular determinants of life span. (2010 Jan) | Shi Y | Pflugers Arch |
| 26352076 | Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum? (2016 Apr) | Caglayan EK | J Perinat Med |
| 27170122 | Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward. (2016 May 11) | Engel GL | J Neurosci |
| 25736869 | Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: a candidate gene approach. (2015 Jan) | Pieters N | Mech Ageing Dev |
| 26391109 | Ageing, metabolism and cardiovascular disease. (2016 Apr 15) | Costantino S | J Physiol |
| 25273948 | Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. (2014 Oct 2) | Kedenko L | BMC Med Genet |