Gene: GRIP1

23426
FRASRS3|GRIP
glutamate receptor interacting protein 1
protein-coding
12q14.3
Ensembl:ENSG00000155974 MIM:604597 Vega:OTTHUMG00000169019 UniprotKB:Q9Y3R0
NG_021400.1
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.613e-1 (AD)  8.947e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR1580.93
RAB3C0.928
NBEA0.922
KCNAB10.92
PCLO0.917
ELMOD10.916
KRT2220.916
NRXN30.914
ROBO20.912
PAK30.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.583
RAB13-0.544
MYL3-0.53
RNF135-0.53
COPZ2-0.525
ROM1-0.51
RHOD-0.501
HEY2-0.501
GNG11-0.497
AGTRAP-0.497

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRIP1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRIP1 mRNA"19114083
C0396742,3,4,5-tetrachlorophenate"GRIP1 gene SNP affects the susceptibility to 2,3,4,5-tetrachlorophenate"25622337
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GRIP1 mRNA"23196670
C0541213-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanoneGRIP1 gene SNP affects the susceptibility to 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone25622337
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
C014949acetylhydrazineacetylhydrazine results in decreased expression of GRIP1 mRNA15282401
D020106AcrylamideAcrylamide results in increased expression of GRIP1 mRNA28959563
D000393Air PollutantsAir Pollutants analog results in decreased expression of GRIP1 mRNA21757418
D000584AmilorideGRIP1 gene SNP affects the susceptibility to Amiloride25622337
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GRIP1 mRNA"17331233
C547126AZM551248AZM551248 results in decreased expression of GRIP1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRIP1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRIP1 mRNA23735875
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [GRIP1 protein binds to NR1I3 protein]24224465
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GRIP1 mRNA25566086
D004958EstradiolGRIP1 gene SNP affects the susceptibility to Estradiol25622337
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of GRIP1 mRNA25181051
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
C018475butyraldehydebutyraldehyde results in decreased expression of GRIP1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIP1 gene20938992
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in increased expression of GRIP1 mRNA18355967
D003042CocaineCocaine results in increased phosphorylation of GRIP1 protein19439608
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GRIP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GRIP1 mRNA27392435|2759478
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
C118739entinostatentinostat results in decreased expression of GRIP1 mRNA27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
D000431EthanolEthanol affects the expression of GRIP1 mRNA11772933
D000431EthanolEthanol results in decreased expression of GRIP1 mRNA20655511
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIP1 gene20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GRIP1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of GRIP1 mRNA27392435
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRIP1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GRIP1 mRNA26011545
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of GRIP1 mRNA25607892
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GRIP1 mRNA21061450
D010795Phthalic AcidsPhthalic Acids results in increased expression of GRIP1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GRIP1 mRNA19710929
C037850PK 11195PK 11195 inhibits the reaction [GRIP1 protein binds to NR1I3 protein]24224465
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of GRIP1 mRNA22714537
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
D011441PropylthiouracilPropylthiouracil results in increased expression of GRIP1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRIP1 mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of GRIP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRIP1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of GRIP1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased palmitoylation of GRIP1 protein26348896
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GRIP1 gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of GRIP1 mRNA25607892
C025643vinclozolinvinclozolin affects the expression of GRIP1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-NAS15572661  
GO:0005515protein binding-IPI11641419  16362036  16957778  17545996  17635946  17932106  
GO:0008013beta-catenin binding-TAS16344550  
GO:0008022protein C-terminus binding-IPI16344550  
GO:0030159receptor signaling complex scaffold activity-NAS10197531  
GO:0035259glucocorticoid receptor binding-IPI15769988  
GO:0050681androgen receptor binding-NAS15572661  
GO ID GO Term Qualifier Evidence PubMed
GO:0008104protein localization-IEA-  
GO:0016358dendrite development-IEA-  
GO:0030521androgen receptor signaling pathway-NAS15572661  
GO:0035556intracellular signal transduction-NAS10197531  
GO:0045893positive regulation of transcription, DNA-templated-NAS15572661  
GO:0150012positive regulation of neuron projection arborization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IEA-  
GO:0043005neuron projection-ISS-  
GO:0045121membrane raft-IEA-  
GO:0045211postsynaptic membrane-IEA-  
GO:0055037recycling endosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490364High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. (2016 Aug)Lo CLPLoS Genet
20018661Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. (2010 Jan 5)Thorsen TSProc Natl Acad Sci U S A