Gene info: ID 23429

Gene: RYBP

GENE ID: 23429

Synonyms: AAP1|APAP-1|DEDAF|YEAF1

Description: RING1 and YY1 binding protein

Gene type: protein-coding

Location: 3p13

dbXrefs: Ensembl:ENSG00000163602 MIM:607535 UniprotKB:Q8N488

RefSeq: NC_000003.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.641e-1 (AD) 7.363e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09006487	chr3:72424982	RYBP		4.850e-9	Maternal smoking in pregnancy	27040690
cg09006487	chr3:72424982	RYBP		2.700e-11	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDS5A	0.879
NOL11	0.876
PPP4R2	0.875
CGGBP1	0.861
KANSL2	0.86
BIRC2	0.859
DERL1	0.858
BUB3	0.856
NUFIP2	0.855
TBC1D23	0.853

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.586
OR4F29	-0.55
HES5	-0.294
NXNL1	-0.294
GLI1	-0.275
ALDH1L1-AS2	-0.229
REM1	-0.226
HPDL	-0.221
COX4I2	-0.221
FOXS1	-0.219

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of RYBP mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of RYBP mRNA"	21346803
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RYBP mRNA	12958071
D000082	Acetaminophen	Acetaminophen results in increased expression of RYBP mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of RYBP mRNA	17562736
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RYBP mRNA	20504355
D004958	Estradiol	Estradiol results in increased expression of RYBP mRNA	25210133
C006780	bisphenol A	bisphenol A results in decreased methylation of RYBP promoter	27312807
C006780	bisphenol A	bisphenol A affects the expression of RYBP mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of RYBP mRNA	27509014
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased methylation of RYBP gene	27509014
D002104	Cadmium	Cadmium results in increased expression of RYBP mRNA	21120746
C099555	CD 437	CD 437 results in decreased expression of RYBP mRNA	12958071
C100187	chloropicrin	chloropicrin results in increased expression of RYBP mRNA	26352163
D003042	Cocaine	Cocaine results in increased expression of RYBP mRNA	18000554
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of RYBP mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of RYBP mRNA	19549813
C029892	cupric chloride	cupric chloride affects the expression of RYBP mRNA	17211630
C030973	cupric oxide	cupric oxide results in increased expression of RYBP mRNA	22077320
D016572	Cyclosporine	Cyclosporine results in increased expression of RYBP mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of RYBP mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of RYBP mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of RYBP mRNA	27392435
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of RYBP mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RYBP mRNA"	22485181
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA	24690739
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of RYBP mRNA	17475347
D005485	Flutamide	Flutamide results in increased expression of RYBP mRNA	24793618
D005557	Formaldehyde	Formaldehyde results in increased expression of RYBP mRNA	23649840
D005839	Gentamicins	Gentamicins results in increased expression of RYBP mRNA	22061828
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of RYBP mRNA	20044591\|2117940
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RYBP mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of RYBP mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of RYBP mRNA	27392435
C045463	leflunomide	leflunomide results in increased expression of RYBP mRNA	28988120
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of RYBP mRNA	28001369
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of RYBP mRNA	20971185
D010081	Oxazolone	Oxazolone results in increased expression of RYBP mRNA	23999411
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of RYBP mRNA	18593933
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of RYBP protein	26178269
D010634	Phenobarbital	Phenobarbital affects the expression of RYBP mRNA	19159669
D010894	Piroxicam	Piroxicam results in decreased expression of RYBP mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of RYBP mRNA	23557933
D010938	Plant Oils	Plant Oils results in increased expression of RYBP mRNA	23370395
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of RYBP mRNA	21427059
C010327	salinomycin	salinomycin results in decreased expression of RYBP mRNA	19682730
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of RYBP mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of RYBP mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of RYBP mRNA	19073995
D012834	Silver	Silver results in increased expression of RYBP mRNA	26014281
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of RYBP mRNA	27914987
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of RYBP mRNA	25613284
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of RYBP gene	27618143
C012589	trichostatin A	trichostatin A affects the expression of RYBP mRNA	28542535
D014520	Urethane	Urethane results in increased expression of RYBP mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased expression of RYBP mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of RYBP mRNA	24935251\|2915479
D014635	Valproic Acid	Valproic Acid results in decreased expression of RYBP mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RYBP gene	25487561
C025643	vinclozolin	vinclozolin results in increased expression of RYBP mRNA	23034163
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of RYBP mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of RYBP mRNA	19244175
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of RYBP mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003677	DNA binding	-	IEA	-
GO:0003714	transcription corepressor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	16189514 16943429 17070805 19098711 20696397 24855944 25416956 26496610 26687479 27060496 27705803
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0007275	multicellular organism development	-	TAS	10369680
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	-	IMP	27060496
GO:0035518	histone H2A monoubiquitination	-	IDA	16943429
GO:0043065	positive regulation of apoptotic process	-	IMP	27060496
GO:0045893	positive regulation of transcription, DNA-templated	-	IMP	27060496
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	27060496
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IEA	-
GO:0031519	PcG protein complex	colocalizes_with	IDA	16943429

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	TAS
R-HSA-8953750	Transcriptional Regulation by E2F6	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28369212	Associations between single nucleotide polymorphisms in RYBP and the prognosis of hepatocellular carcinoma in a Chinese population. (2017 May 1)	Zhu X	Carcinogenesis