Gene: TARDBP

23435
ALS10|TDP-43
TAR DNA binding protein
protein-coding
1p36.22
Ensembl:ENSG00000120948 MIM:605078 Vega:OTTHUMG00000002120 UniprotKB:Q13148
NG_008734.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.009e-1 (AD)  2.346e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRSF10.945
HNRNPA30.94
UBE2R20.933
RBM390.931
GPBP10.931
SRSF40.927
HNRNPA2B10.927
DDX230.922
SF3B10.918
STAU10.917

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.791
OR4F5-0.781
HES5-0.192
OR4F16-0.167
MTRNR2L10-0.165
REN-0.157
MTRNR2L6-0.154
MTRNR2L9-0.145
NXNL1-0.144
RSPO1-0.144

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TARDBP mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TARDBP mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TARDBP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TARDBP mRNA"27188386
D000965AntimonyAntimony results in decreased expression of TARDBP mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of TARDBP mRNA17547211
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TARDBP mRNA24449571
D001104ArbutinArbutin results in increased expression of TARDBP mRNA17103032
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TARDBP mRNA"26238291
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the localization of TARDBP protein19765185
C006780bisphenol Abisphenol A affects the expression of TARDBP mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of TARDBP promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of TARDBP mRNA24534842
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TARDBP promoter23359474
C006780bisphenol Abisphenol A results in increased expression of TARDBP mRNA25181051
C022777bufalinbufalin results in decreased expression of TARDBP protein23091618
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TARDBP mRNA18804290
C018475butyraldehydebutyraldehyde results in decreased expression of TARDBP mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TARDBP mRNA19010381
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TARDBP mRNA23650126
D002737ChloropreneChloroprene results in decreased expression of TARDBP mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TARDBP mRNA28472532
C031180chrysenechrysene results in increased expression of TARDBP mRNA26377693
D003300CopperCopper results in decreased expression of TARDBP mRNA26293553
D003300CopperCopper results in increased expression of TARDBP protein21146535
C029892cupric chloridecupric chloride inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
C029892cupric chloridecupric chloride results in decreased expression of TARDBP mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of TARDBP mRNA21163907|2556210
C014347decitabinedecitabine affects the expression of TARDBP mRNA23300844
C570445diacetylbis(4-methylthiosemicarbazonato)copper(II)diacetylbis(4-methylthiosemicarbazonato)copper(II) inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
C570445diacetylbis(4-methylthiosemicarbazonato)copper(II)diacetylbis(4-methylthiosemicarbazonato)copper(II) inhibits the reaction [TARDBP protein binds to TARDBP protein modified form]22879928
C570445diacetylbis(4-methylthiosemicarbazonato)copper(II)diacetylbis(4-methylthiosemicarbazonato)copper(II) promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form]22879928
C570445diacetylbis(4-methylthiosemicarbazonato)copper(II)diacetylbis(4-methylthiosemicarbazonato)copper(II) inhibits the reaction [SOD1 protein mutant form results in increased phosphorylation of TARDBP protein]22879928
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TARDBP promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TARDBP mRNA21266533
D002945CisplatinCisplatin affects the expression of TARDBP mRNA23300844
D002945CisplatinCisplatin results in increased phosphorylation of TARDBP protein22006019
D004008DiclofenacDiclofenac results in decreased expression of TARDBP mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TARDBP mRNA26924002
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of TARDBP promoter23359474
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TARDBP mRNA27638505
C024629dimethyl phthalatedimethyl phthalate affects the expression of TARDBP mRNA26924002
D004318DoxycyclineDoxycycline analog results in decreased expression of TARDBP protein24019256
D004318Doxycycline[Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein]24019256
D004640EmetineEmetine affects the reaction [TARDBP protein binds to TIA1 protein]19765185
D004640EmetineEmetine affects the reaction [TARDBP protein binds to TIAR protein]19765185
C118739entinostatentinostat results in decreased expression of TARDBP mRNA26272509
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TARDBP protein23301498
D005485FlutamideFlutamide results in increased expression of TARDBP mRNA24136188
D005839GentamicinsGentamicins results in increased expression of TARDBP mRNA22061828
D005897GlafenineGlafenine results in increased expression of TARDBP mRNA24136188
C545536glyoxalbis(N(4)-methylthiosemicarbazonato)copper(II)glyoxalbis(N(4)-methylthiosemicarbazonato)copper(II) inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
C031927hydroquinonehydroquinone affects the expression of TARDBP protein20021034
C492448ICG 001ICG 001 results in decreased expression of TARDBP mRNA26191083
C045463leflunomideleflunomide results in decreased expression of TARDBP mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TARDBP mRNA21641980
D008627Mercuric ChlorideMercuric Chloride results in increased expression of TARDBP mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TARDBP mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TARDBP mRNA28001369
D015741MetriboloneMetribolone results in decreased expression of TARDBP protein17152098
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TARDBP mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TARDBP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TARDBP mRNA"25620056
C051752nefazodonenefazodone results in increased expression of TARDBP mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of TARDBP mRNA17312168
C012655nimesulidenimesulide results in increased expression of TARDBP mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of TARDBP protein19716841
C025256nonylphenolnonylphenol results in decreased expression of TARDBP protein19260726
C025589ochratoxin Aochratoxin A results in decreased expression of TARDBP mRNA19287073
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TARDBP mRNA25729387
D010269Paraquatcupric chloride inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
D010269Paraquatdiacetylbis(4-methylthiosemicarbazonato)copper(II) inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
D010269Paraquatdiacetylbis(4-methylthiosemicarbazonato)copper(II) promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form]22879928
D010269Paraquatglyoxalbis(N(4)-methylthiosemicarbazonato)copper(II) inhibits the reaction [Paraquat affects the localization of TARDBP protein]22879928
D010269ParaquatParaquat affects the localization of TARDBP protein22879928
D010269ParaquatParaquat results in increased expression of TARDBP protein modified form22879928
D010269Paraquatpyrazolanthrone promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form]22879928
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of TARDBP mRNA19095052
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TARDBP mRNA23948077
C046012pentanalpentanal results in decreased expression of TARDBP mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of TARDBP mRNA23091169
D019800PhenolPhenol results in decreased expression of TARDBP mRNA17547211
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TARDBP mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TARDBP mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of TARDBP mRNA23811191
D011374ProgesteroneProgesterone results in decreased expression of TARDBP mRNA18037150
C432165pyrazolanthronepyrazolanthrone promotes the reaction [Paraquat results in increased expression of TARDBP protein modified form]22879928
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TARDBP mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TARDBP mRNA19073995
C080703SK&F 83959SK&F 83959 results in increased expression of TARDBP protein25852303
C009277sodium arsenatesodium arsenate results in increased expression of TARDBP mRNA21795629
C017947sodium arsenite[Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein]24019256
C017947sodium arsenitesodium arsenite affects the localization of TARDBP protein22879928|2401925
C017947sodium arsenitesodium arsenite affects the localization of TARDBP protein19765185
C017947sodium arsenitesodium arsenite promotes the reaction [TARDBP protein binds to TIA1 protein]19765185
C017947sodium arsenitesodium arsenite promotes the reaction [TARDBP protein binds to TIAR protein]19765185
D018038Sodium SeleniteSodium Selenite results in decreased expression of TARDBP mRNA18175754
D053260SootSoot results in decreased expression of TARDBP mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TARDBP mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TARDBP mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TARDBP mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TARDBP mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TARDBP mRNA"27188386
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TARDBP mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TARDBP mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TARDBP mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of TARDBP mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IBA21873635  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003690double-stranded DNA binding-IDA7745706  
GO:0003700DNA-binding transcription factor activity-TAS7745706  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-IDA11285240  
GO:0003727single-stranded RNA binding-IBA21873635  
GO:0003730mRNA 3'-UTR binding-IBA21873635  
GO:0003730mRNA 3'-UTR binding-IDA17481916  
GO:0005515protein binding-IPI20740007  21903422  23541532  24169621  29109149  
GO:0042802identical protein binding-IPI19383787  21666678  22193716  23384725  26099433  26735904  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IMP18305152  
GO:0006366transcription by RNA polymerase II-TAS7745706  
GO:0006397mRNA processing-IEA-  
GO:0008380RNA splicing-IDA11285240  
GO:0010629negative regulation of gene expression-IMP18305152  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0034976response to endoplasmic reticulum stress-IEA-  
GO:0042981regulation of apoptotic process-IMP18305152  
GO:0043922negative regulation by host of viral transcription-IDA7745706  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051252regulation of RNA metabolic process-IBA21873635  
GO:0051726regulation of cell cycle-IMP18305152  
GO:00709353'-UTR-mediated mRNA stabilization-IBA21873635  
GO:00709353'-UTR-mediated mRNA stabilization-IDA17481916  
GO:0071765nuclear inner membrane organization-IMP18305152  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11285240  17481916  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005726perichromatin fibrils-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0016607nuclear speck-IEA-  
GO:0035061interchromatin granule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20472259[Research in amyotrophic lateral sclerosis: what is new in 2009?]. (2010 Aug-Sep)Pradat PFRev Neurol (Paris)