Gene: OTP

23440
-
orthopedia homeobox
protein-coding
5q14.1
Ensembl:ENSG00000171540 MIM:604529 Vega:OTTHUMG00000102171 UniprotKB:Q5XKR4
NC_000005.10
PubMed
0   ANCO-SNPs
OD|ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.484e-1 (AD)  9.358e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOXB10.997
LHX50.994
HMX20.992
SIM10.986
C22orf420.984
NTS0.98
HCRT0.98
SIX60.969
FEZF10.964
HMX30.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGLL-0.395
LZTS1-0.384
KCNH3-0.357
CYTH3-0.356
SHANK3-0.352
MGAT5B-0.345
SLC17A7-0.341
MLLT6-0.339
DDN-0.339
GRASP-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of OTP gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of OTP mRNA16483693
C015001arsenitearsenite results in increased methylation of OTP promoter23974009
D001280AtrazineAtrazine results in decreased expression of OTP mRNA25929836
C006780bisphenol Abisphenol A affects the methylation of OTP promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of OTP mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OTP gene20938992
D003703DemecolcineDemecolcine results in increased expression of OTP mRNA23649840
C017435enilconazoleenilconazole affects the expression of OTP mRNA19124165
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OTP gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of OTP mRNA23649840
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of OTP protein18951874
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OTP protein18951874
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OTP gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of OTP mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of OTP mRNA"20188158
D009151Mustard GasMustard Gas results in increased expression of OTP mRNA15674844
D010269ParaquatParaquat results in decreased expression of OTP mRNA22563483
D010936Plant ExtractsPlant Extracts results in decreased expression of OTP mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OTP mRNA24058054
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of OTP protein18951874
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of OTP protein18951874
D014635Valproic AcidValproic Acid results in increased methylation of OTP gene29154799
D014750VincristineVincristine results in increased expression of OTP mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002052positive regulation of neuroblast proliferation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0021879forebrain neuron differentiation-IEA-  
GO:0021979hypothalamus cell differentiation-IEA-  
GO:0021985neurohypophysis development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29244540Overcoming Impediments to OTP Expansion in the United States and Abroad. (2018 Jan 28)Parrino MWSubst Use Misuse
27664553Use of and reasons for using multiple other tobacco products in daily and nondaily smokers: Associations with cigarette consumption and nicotine dependence. (2016 Nov 1)Dunbar MSDrug Alcohol Depend
21635762Age differences in heroin and prescription opioid abuse among enrolees into opioid treatment programs. (2011 Jun 2)Cleland CMSubst Abuse Treat Prev Policy
21776440Distance traveled and cross-state commuting to opioid treatment programs in the United States. (2011)Rosenblum AJ Environ Public Health