Gene: SF3B1

23451
Hsh155|MDS|PRP10|PRPF10|SAP155|SF3b155
splicing factor 3b subunit 1
protein-coding
2q33.1
Ensembl:ENSG00000115524 MIM:605590 Vega:OTTHUMG00000154447 UniprotKB:O75533
NG_032903.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.558e-1 (AD)  9.833e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX50.949
ARGLU10.946
SRSF110.943
DDX170.942
RBM390.939
GPBP1L10.938
ZC3H11A0.936
PRPF4B0.936
WDR260.93
SUN10.927

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.771
OR4F29-0.757
HMHB1-0.159
KRTAP19-1-0.157
NANOGNB-0.151
MTRNR2L6-0.149
MTRNR2L10-0.148
OR4F16-0.148
HES5-0.14
MTRNR2L9-0.137

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SF3B1 mRNA"19162173
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SF3B1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SF3B1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SF3B1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SF3B1 mRNA22230336
D000086AcetazolamideAcetazolamide results in increased expression of SF3B1 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SF3B1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SF3B1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SF3B1 mRNA16483693
D001104ArbutinArbutin results in increased expression of SF3B1 mRNA17103032
D001280AtrazineAtrazine results in decreased expression of SF3B1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SF3B1 mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SF3B1 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of SF3B1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SF3B1 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of SF3B1 protein28903499
D002737ChloropreneChloroprene results in increased expression of SF3B1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SF3B1 mRNA18668222
D002922CiguatoxinsCiguatoxins affects the expression of SF3B1 mRNA18353800
D016572CyclosporineCyclosporine results in decreased expression of SF3B1 mRNA21632981
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of SF3B1 mRNA23914054
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SF3B1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of SF3B1 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SF3B1 mRNA"22485181
D004237DiuronDiuron results in decreased expression of SF3B1 mRNA25152437
D005557FormaldehydeFormaldehyde results in decreased expression of SF3B1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of SF3B1 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SF3B1 mRNA21179406
D008727MethotrexateSF3B1 protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SF3B1 mRNA26272509
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SF3B1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SF3B1 mRNA"25554681
D009532NickelNickel results in decreased expression of SF3B1 mRNA24084258
C028007nickel monoxidenickel monoxide results in decreased expression of SF3B1 mRNA19167457
C016030pantogabpantogab results in increased expression of SF3B1 mRNA17379144
D010269ParaquatParaquat results in increased expression of SF3B1 mRNA12595580
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SF3B1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SF3B1 protein26879310
D010634PhenobarbitalPhenobarbital results in decreased expression of SF3B1 mRNA23091169
C012526quercitrinquercitrin results in decreased expression of SF3B1 mRNA25193878
C059514resveratrolresveratrol results in decreased expression of SF3B1 protein25505154
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of SF3B1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of SF3B1 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of SF3B1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of SF3B1 mRNA21297353
D012999SomanSoman results in increased expression of SF3B1 mRNA19281266
C004648testosterone enanthatetestosterone enanthate affects the expression of SF3B1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SF3B1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SF3B1 mRNA21354282
D019284ThapsigarginThapsigargin results in increased expression of SF3B1 protein24648495
D013849ThimerosalThimerosal results in decreased expression of SF3B1 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SF3B1 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SF3B1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of SF3B1 mRNA26272509
C012589trichostatin Atrichostatin A results in decreased expression of SF3B1 mRNA15901671
C057693troglitazonetroglitazone results in decreased expression of SF3B1 mRNA28973697
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of SF3B1 mRNA18422935
D014635Valproic AcidValproic Acid results in decreased expression of SF3B1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of SF3B1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SF3B1 gene25560391
C025643vinclozolinvinclozolin affects the expression of SF3B1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of SF3B1 mRNA20566332
D002762CholecalciferolCholecalciferol results in increased expression of SF3B1 mRNA16508948
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of SF3B1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of SF3B1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003729mRNA binding-IBA21873635  
GO:0005515protein binding-IPI19515850  22365833  26575292  
GO ID GO Term Qualifier Evidence PubMed
GO:0000245spliceosomal complex assembly-IBA21873635  
GO:0000375RNA splicing, via transesterification reactions-NAS9585501  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA11252167  28781166  
GO:0000398mRNA splicing, via spliceosome-NAS9585501  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0045815positive regulation of gene expression, epigenetic-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18559850  28781166  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-NAS9585501  
GO:0005686U2 snRNP-IBA21873635  
GO:0005686U2 snRNP-IDA11252167  
GO:0005689U12-type spliceosomal complex-IBA21873635  
GO:0005689U12-type spliceosomal complex-IDA15146077  
GO:0016607nuclear speck-IDA-  
GO:0034693U11/U12 snRNP-IDA11252167  
GO:0071004U2-type prespliceosome-IBA21873635  
GO:0071005U2-type precatalytic spliceosome-IDA28781166  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72165mRNA Splicing - Minor PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget