Gene: ANGPTL2

23452
ARP2|HARP
angiopoietin like 2
protein-coding
9q33.3
Ensembl:ENSG00000136859 MIM:605001 Vega:OTTHUMG00000020695 UniprotKB:Q9UKU9
NC_000009.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.883e-1 (AD)  5.303e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC42EP10.771
TMC60.762
PRR5L0.754
CPNE20.753
ELOVL10.744
SOX100.74
THBS20.739
TMC70.738
ICOSLG0.737
SMIM50.737

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRB14-0.379
CNGB1-0.332
TRIML2-0.327
UBXN10-0.326
CUX2-0.323
DBH-0.31
LRRC2-0.31
CTXN3-0.308
NEUROD1-0.306
CCNO-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ANGPTL2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANGPTL2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANGPTL2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ANGPTL2 mRNA"23196670
D000082AcetaminophenAcetaminophen results in decreased expression of ANGPTL2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANGPTL2 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ANGPTL2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of ANGPTL2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of ANGPTL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANGPTL2 mRNA26238291
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ANGPTL2 mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of ANGPTL2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ANGPTL2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ANGPTL2 gene28505145
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA20847119
D020122tert-Butylhydroperoxidepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA15003993
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ANGPTL2 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANGPTL2 mRNA24763279
D003345CorticosteroneCorticosterone results in decreased expression of ANGPTL2 mRNA15755911
D016572CyclosporineCyclosporine results in decreased expression of ANGPTL2 mRNA22147139
D003561CytarabineCytarabine results in decreased expression of ANGPTL2 mRNA21198554
D000069439DasatinibDasatinib results in increased expression of ANGPTL2 mRNA20579391
C014476diethyl maleatediethyl maleate results in decreased expression of ANGPTL2 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ANGPTL2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPTL2 mRNA]17854601
C024565ethylene dichlorideethylene dichloride results in decreased expression of ANGPTL2 mRNA28189721
C540355fenamidonefenamidone results in increased expression of ANGPTL2 mRNA27029645
C082360fipronilfipronil results in decreased expression of ANGPTL2 mRNA23962444
D005472FluorouracilANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D002955LeucovorinANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ANGPTL2 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of ANGPTL2 mRNA28973697
C051890irinotecanANGPTL2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D007545IsoproterenolIsoproterenol results in decreased expression of ANGPTL2 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ANGPTL2 mRNA24796395
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ANGPTL2 mRNA21641980
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to ANGPTL2 promoter]20348232
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ANGPTL2 mRNA20713471
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ANGPTL2 mRNA17475336
D009569Nitric OxideANGPTL2 gene mutant form results in decreased chemical synthesis of Nitric Oxide27402837
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ANGPTL2 mRNA18692542
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA20847119
C060836pioglitazonepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]20847119
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ANGPTL2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ANGPTL2 mRNA23557933
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ANGPTL2 mRNA17404688
D011441PropylthiouracilPropylthiouracil affects the expression of ANGPTL2 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ANGPTL2 mRNA27029645
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ANGPTL2 mRNA14699072
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ANGPTL2 mRNA20847119
C009277sodium arsenatesodium arsenate results in decreased expression of ANGPTL2 mRNA23922661
D018038Sodium SeleniteSodium Selenite results in decreased expression of ANGPTL2 mRNA18175754
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ANGPTL2 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of ANGPTL2 mRNA14699072
D013739TestosteroneTestosterone results in decreased expression of ANGPTL2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANGPTL2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ANGPTL2 mRNA18691609
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANGPTL2 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of ANGPTL2 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ANGPTL2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ANGPTL2 mRNA28111298
C012589trichostatin Atrichostatin A results in decreased expression of ANGPTL2 mRNA15901671
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ANGPTL2 mRNA29024780
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ANGPTL2 mRNA]20847119
C057693troglitazonetroglitazone results in decreased expression of ANGPTL2 mRNA28973697
D014520UrethaneUrethane results in decreased expression of ANGPTL2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ANGPTL2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ANGPTL2 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of ANGPTL2 mRNA15901671
D014638VanadatesVanadates results in decreased expression of ANGPTL2 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of ANGPTL2 mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of ANGPTL2 mRNA22570695
C029297vinylidene chloridevinylidene chloride results in increased expression of ANGPTL2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS10473614  
GO:0005515protein binding-IPI22660330  24899623  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-TAS10473614  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS10473614  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23205131Angiopoietin-like protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung cancer. (2012 Dec)Sasaki HOncol Lett
27365403Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community: The Hisayama Study. (2016 Aug)Hata JArterioscler Thromb Vasc Biol