Gene: FOLH1

2346
FGCP|FOLH|GCP2|GCPII|NAALAD1|NAALAdase|PSM|PSMA|mGCP
folate hydrolase 1
protein-coding
11p11.12
Ensembl:ENSG00000086205 MIM:600934 Vega:OTTHUMG00000166625 UniprotKB:Q04609
NG_029170.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.700e-1 (AD)  5.013e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOG0.946
TMEM1440.945
ST180.939
LDB30.927
EVI2A0.924
ASPA0.918
HHIP0.917
NINJ20.916
COL4A50.916
C21orf910.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.456
NEUROD1-0.442
CHRNA2-0.431
GPR153-0.425
HCN4-0.409
LTK-0.407
WTIP-0.403
CALB2-0.392
PCDH8-0.39
SHROOM3-0.389

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00089Capromab pendetideBiotechDrug145464-28-4ApprovedTarget
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB06928(2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACIDSmall MoleculeExperimentalTarget
DB07754N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acidSmall MoleculeExperimentalTarget
DB08835Spaglumic AcidSmall Molecule4910-46-7ApprovedTarget
ID Drug Name Action PubMed
C5727231-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]"26729308
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in decreased expression of FOLH1 mRNA"26729308
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog results in increased expression of FOLH1 mRNA"26729308
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FOLH1 mRNA"23146750
C5443802-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of FOLH1 mRNA28522335
C4021072-(phosphonomethyl)pentanedioic acid2-(phosphonomethyl)pentanedioic acid binds to and results in decreased activity of FOLH1 protein19895667
C4021072-(phosphonomethyl)pentanedioic acid[2-(phosphonomethyl)pentanedioic acid binds to and results in decreased activity of FOLH1 protein] which results in increased abundance of isospaglumic acid19895667
C109238acylineacyline results in increased expression of FOLH1 mRNA17510436
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of FOLH1 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FOLH1 mRNA27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of FOLH1 mRNA12711008
D015119Aminocaproic Acid"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOLH1 mRNA16483693
C015001arsenitearsenite results in increased methylation of FOLH1 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of FOLH1 mRNA25181051
C118536bombesin (7-14)"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
D002509CephaloridineCephaloridine results in decreased expression of FOLH1 mRNA18500788
D003300Copper"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
D016572CyclosporineCyclosporine results in decreased expression of FOLH1 mRNA20106945|2798913
D003634DDTDDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]25682698
D003634DDTDDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]25682698
D003634DDTDDT results in increased expression of FOLH1 protein25682698
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]25682698
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene results in increased expression of FOLH1 protein25682698
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FOLH1 mRNA24535843
C115058difenoconazoledifenoconazole results in increased expression of FOLH1 mRNA12711008
D002117CalcitriolAR protein affects the reaction [Calcitriol results in decreased expression of FOLH1 protein]18247401
D002117CalcitriolCalcitriol results in decreased expression of FOLH1 protein18247401
D004317DoxorubicinDoxorubicin results in increased expression of FOLH1 mRNA15033991
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FOLH1 mRNA26159488
D017313FenretinideFenretinide results in decreased expression of FOLH1 mRNA28973697
C027172isospaglumic acid"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
C027172isospaglumic acidisospaglumic acid binds to FOLH1 protein24508213
C027172isospaglumic acid[2-(phosphonomethyl)pentanedioic acid binds to and results in decreased activity of FOLH1 protein] which results in increased abundance of isospaglumic acid19895667
D015741Metribolone"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane analog inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]"26729308
D015741MetriboloneDDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]25682698
D015741MetriboloneDDT inhibits the reaction [Metribolone results in decreased expression of FOLH1 protein]25682698
D015741MetriboloneDichlorodiphenyl Dichloroethylene inhibits the reaction [Metribolone results in decreased expression of FOLH1 mRNA]25682698
D015741Metribolone"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 mRNA"26709203
D015741Metribolone"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 protein"26709203
D015741MetriboloneMetribolone results in decreased expression of FOLH1 mRNA12711008|2568269
D015741MetriboloneMetribolone results in decreased expression of FOLH1 protein17152098|2568269
D009532NickelNickel results in decreased expression of FOLH1 mRNA25583101
D010100OxygenOxygen deficiency results in increased expression of FOLH1 mRNA26516004
D010424PentobarbitalFOLH1 protein results in increased susceptibility to Pentobarbital15387974
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FOLH1 mRNA23146750
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FOLH1 mRNA24535843
C011978phentin acetatephentin acetate results in increased expression of FOLH1 mRNA12711008
C006253pirinixic acidpirinixic acid results in increased expression of FOLH1 mRNA12832660
D011441PropylthiouracilPropylthiouracil results in decreased expression of FOLH1 mRNA24780913
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of FOLH1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of FOLH1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FOLH1 mRNA25895662
D012999SomanSoman results in decreased expression of FOLH1 mRNA19281266
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FOLH1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOLH1 mRNA24680724
C009424tetramethrintetramethrin results in decreased expression of FOLH1 mRNA12711008
C016805tris(1,3-dichloro-2-propyl)phosphate"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 mRNA"26709203
C016805tris(1,3-dichloro-2-propyl)phosphate"[Metribolone co-treated with tris(1,3-dichloro-2-propyl)phosphate] affects the expression of FOLH1 protein"26709203
D014631Valerates"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]"24508213
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FOLH1 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of FOLH1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of FOLH1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004181metallocarboxypeptidase activity-IDA12949938  17241121  24863754  
GO:0008233peptidase activity-NAS9375657  
GO:0016805dipeptidase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO:1904492Ac-Asp-Glu binding-IDA24863754  
GO:1904493tetrahydrofolyl-poly(glutamate) polymer binding-IDA24863754  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA12949938  
GO:0006508proteolysis-NAS9375657  
GO:0006760folic acid-containing compound metabolic process-IEA-  
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO:0035609C-terminal protein deglutamylation-IDA12949938  17241121  24863754  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IDA12949938  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009986cell surface-IDA12949938  
GO:0016020membrane-NAS9375657  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21597034The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)Ye XPsychosom Med
19172696The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. (2008)Eklof VScand J Clin Lab Invest
27070640MADD-FOLH1 Polymorphisms and Their Haplotypes with Serum Lipid Levels and the Risk of Coronary Heart Disease and Ischemic Stroke in a Chinese Han Population. (2016 Apr 8)Wu DFNutrients
22479380Genetic and non-genetic influences during pregnancy on infant global and site specific DNA methylation: role for folate gene variants and vitamin B12. (2012)McKay JAPLoS One
18635682Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm. (2008 Nov)Giusti BJ Med Genet
21338559Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population. (2011 Oct)Huang TPublic Health Nutr