Gene: HEY1

23462
BHLHb31|CHF2|HERP2|HESR1|HRT-1|OAF1|hHRT1
hes related family bHLH transcription factor with YRPW motif 1
protein-coding
8q21.13
Ensembl:ENSG00000164683 MIM:602953 Vega:OTTHUMG00000164641 UniprotKB:Q9Y5J3
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.566e-1 (AD)  4.624e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FHL10.86
VMA210.846
RAB2A0.845
SUB10.844
MOCS20.844
DSTN0.843
PPT10.841
CCNY0.838
MPC20.838
CDC1230.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.68
OR4F29-0.641
MTRNR2L6-0.311
MTRNR2L10-0.306
ZBTB20-0.296
PRR26-0.296
FOLR3-0.288
S100A12-0.287
CSAG3-0.28
KCNJ15-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HEY1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HEY1 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of HEY1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HEY1 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HEY1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HEY1 mRNA24449571
C006632arsenic trioxidearsenic trioxide affects the methylation of HEY1 promoter26046465
C006632arsenic trioxidearsenic trioxide results in decreased expression of HEY1 mRNA24685274
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of HEY1 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of HEY1 mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of HEY1 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of HEY1 mRNA22323515
C006680baicaleinbaicalein results in increased expression of HEY1 mRNA19160421
C006680baicalein"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]"19160421
C038044baicalinbaicalin results in increased expression of HEY1 mRNA19160421
C038044baicalin"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]"19160421
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of HEY1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HEY1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HEY1 mRNA21569818|2222880
C523462benzyloxycarbonyl-leucyl-leucyl-norleucinalbenzyloxycarbonyl-leucyl-leucyl-norleucinal results in decreased expression of HEY1 mRNA21036696
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of HEY1 mRNA19619570
D004958EstradiolEstradiol affects the expression of HEY1 mRNA15598610
C044887beta-methylcholinebeta-methylcholine affects the expression of HEY1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of HEY1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of HEY1 mRNA25181051
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of HEY1 mRNA26472102
C018475butyraldehydebutyraldehyde results in increased expression of HEY1 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of HEY1 mRNA16934159
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of HEY1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of HEY1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of HEY1 mRNA15467011
D003300CopperCopper deficiency results in increased expression of HEY1 mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of HEY1 mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of HEY1 mRNA19020976
C030973cupric oxidecupric oxide results in increased expression of HEY1 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of HEY1 mRNA20106945|2556210
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of HEY1 mRNA23430952
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HEY1 mRNA26472102
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HEY1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HEY1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of HEY1 mRNA19561079
D019422Dietary SucroseDietary Sucrose results in increased expression of HEY1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HEY1 mRNA28412506
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of HEY1 mRNA26472102
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of HEY1 mRNA26472102
C118739entinostatentinostat results in decreased expression of HEY1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HEY1 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of HEY1 mRNA17938736
C577920GSK126GSK126 results in increased expression of HEY1 mRNA26424790
D017313FenretinideFenretinide results in increased expression of HEY1 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HEY1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HEY1 mRNA24796395
C045463leflunomideleflunomide results in increased expression of HEY1 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HEY1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HEY1 mRNA29104120
D016685MitomycinHEY1 protein affects the susceptibility to Mitomycin16217747
C523799MRK 003MRK 003 results in decreased expression of HEY1 mRNA17804716|2103669
C523799MRK 003MRK 003 results in decreased expression of HEY1 mRNA20197467
D009151Mustard GasMustard Gas results in increased expression of HEY1 mRNA15674844
C484278N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide"N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide results in decreased expression of HEY1 mRNA"21036696
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HEY1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HEY1 mRNA"25554681
D009532NickelNickel results in decreased expression of HEY1 mRNA12540486
D009538NicotineNicotine results in increased expression of HEY1 mRNA23825647
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]"19160421
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]"19160421
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of HEY1 mRNA20971185
C030110oxaliplatinoxaliplatin results in decreased expression of HEY1 mRNA17762391
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HEY1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of HEY1 mRNA25729387
D010126OzoneOzone results in decreased expression of HEY1 mRNA12763052
C006253pirinixic acidpirinixic acid results in decreased expression of HEY1 mRNA20813756
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of HEY1 mRNA21334430
C005556propionaldehydepropionaldehyde results in increased expression of HEY1 mRNA26079696
D011794QuercetinQuercetin results in increased expression of HEY1 mRNA23117658
D015125OxyquinolineOxyquinoline results in decreased expression of HEY1 mRNA21632981
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of HEY1 mRNA21127053
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HEY1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HEY1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HEY1 mRNA22300531|2535159
C017947sodium arsenitesodium arsenite results in increased expression of HEY1 mRNA28595984
D012969Sodium FluorideSodium Fluoride results in increased expression of HEY1 mRNA27862939
D012999SomanSoman results in decreased expression of HEY1 mRNA19281266
D053260SootSoot results in decreased expression of HEY1 mRNA26551751
D010042OuabainOuabain results in increased expression of HEY1 mRNA28795476
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HEY1 mRNA16443690
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of HEY1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HEY1 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HEY1 mRNA21570461|2405805
D019284ThapsigarginThapsigargin results in decreased expression of HEY1 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of HEY1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HEY1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HEY1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HEY1 mRNA21934132|2290670
D014212TretinoinTretinoin results in decreased expression of HEY1 mRNA20488242
C012589trichostatin Atrichostatin A results in increased expression of HEY1 mRNA24935251
C012589trichostatin Atrichostatin A results in decreased expression of HEY1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HEY1 mRNA"26179874
D017973Tungsten CompoundsTungsten Compounds results in increased expression of HEY1 mRNA28666766
D014415TunicamycinTunicamycin results in decreased expression of HEY1 mRNA22378314
D014415TunicamycinTunicamycin results in increased expression of HEY1 mRNA22115781
D014520UrethaneUrethane results in decreased expression of HEY1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HEY1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HEY1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of HEY1 mRNA24383497|2915479
D014635Valproic AcidValproic Acid results in increased methylation of HEY1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HEY1 mRNA19136453
D014635Valproic AcidValproic Acid results in decreased expression of HEY1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HEY1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding-ISS-  
GO:0000989transcription factor activity, transcription factor binding-IDA21290414  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA15485867  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0005515protein binding-IPI10692439  15485867  21454491  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-NAS17611704  
GO:0035939microsatellite binding-IBA21873635  
GO:0035939microsatellite binding-IDA21290414  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0046983protein dimerization activity-IEA-  
GO:1990837sequence-specific double-stranded DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA16043483  21290414  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP11486045  
GO:0001525angiogenesis-IEP11866539  
GO:0001568blood vessel development-IBA21873635  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0003190atrioventricular valve formation-ISS-  
GO:0003203endocardial cushion morphogenesis-ISS-  
GO:0003208cardiac ventricle morphogenesis-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-IDA10964718  25985737  
GO:0007507heart development-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO:0035912dorsal aorta morphogenesis-ISS-  
GO:0036304umbilical cord morphogenesis-ISS-  
GO:0045746negative regulation of Notch signaling pathway-IDA18239137  
GO:0045892negative regulation of transcription, DNA-templated-IDA15485867  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0050767regulation of neurogenesis-IBA21873635  
GO:0060317cardiac epithelial to mesenchymal transition-ISS-  
GO:0060347heart trabecula formation-ISS-  
GO:0060411cardiac septum morphogenesis-ISS-  
GO:0060412ventricular septum morphogenesis-IBA21873635  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060716labyrinthine layer blood vessel development-ISS-  
GO:0060842arterial endothelial cell differentiation-ISS-  
GO:0061314Notch signaling involved in heart development-IC17259303  
GO:0071385cellular response to glucocorticoid stimulus-IEA-  
GO:2000678negative regulation of transcription regulatory region DNA binding-IDA18239137  
GO:2000820negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-IDA18239137  
GO:2001212regulation of vasculogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8940973RUNX2 regulates osteoblast differentiationIEA
R-HSA-8941326RUNX2 regulates bone developmentIEA
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One