Gene: CBX6

23466
-
chromobox 6
protein-coding
22q13.1
Ensembl:ENSG00000183741 MIM:617438 Vega:OTTHUMG00000150456 UniprotKB:O95503
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.782e-1 (AD)  6.197e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05007163chr22:39266069CBX6Gene body7.053e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBXL160.968
SYNPO0.96
NCS10.956
PDZD40.955
BAP10.954
CDK160.953
CAMK2A0.952
FBXO410.952
SEPT50.952
BRSK10.95

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.687
OR4F29-0.638
SNHG18-0.404
TFPI2-0.392
SGMS2-0.392
ANXA13-0.39
C1orf87-0.382
CLEC2B-0.38
VRK2-0.373
C9orf135-0.373

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CBX6 mRNA"21394737
D000082AcetaminophenAcetaminophen results in decreased expression of CBX6 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CBX6 mRNA17562736
D001104ArbutinArbutin results in decreased expression of CBX6 mRNA17103032
D001280AtrazineAtrazine results in decreased expression of CBX6 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CBX6 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of CBX6 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CBX6 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CBX6 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CBX6 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of CBX6 mRNA18353800
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBX6 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of CBX6 mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of CBX6 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of CBX6 mRNA27594783
D002945CisplatinCisplatin results in increased expression of CBX6 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of CBX6 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CBX6 mRNA17602206
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CBX6 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CBX6 mRNA20938992
D019833GenisteinGenistein results in decreased expression of CBX6 mRNA16705744
D019833GenisteinGenistein results in increased expression of CBX6 mRNA20884965
D017313FenretinideFenretinide results in increased expression of CBX6 mRNA28973697
C410337K 7174K 7174 results in increased expression of CBX6 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CBX6 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CBX6 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CBX6 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CBX6 mRNA23649840
C022838nickel chloridenickel chloride results in decreased expression of CBX6 mRNA17312168
D010936Plant ExtractsPlant Extracts results in decreased expression of CBX6 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of CBX6 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of CBX6 mRNA24780913
D011794QuercetinQuercetin results in increased expression of CBX6 mRNA21632981
D012645SelenomethionineSelenomethionine affects the expression of CBX6 mRNA17222674
D012822Silicon DioxideSilicon Dioxide results in increased expression of CBX6 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CBX6 mRNA19073995
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBX6 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBX6 mRNA22298810
D014241TrichloroethyleneTrichloroethylene affects the expression of CBX6 mRNA21135412
C012589trichostatin Atrichostatin A affects the expression of CBX6 mRNA28542535
D014415TunicamycinTunicamycin results in decreased expression of CBX6 mRNA22378314
D014520UrethaneUrethane results in decreased expression of CBX6 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of CBX6 mRNA23179753
C029297vinylidene chloridevinylidene chloride results in decreased expression of CBX6 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of CBX6 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003727single-stranded RNA binding-IEA-  
GO:0005515protein binding-IPI18927235  20543829  20601937  21282530  27705803  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP21282530  
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000792heterochromatin-IEA-  
GO:0005634nucleus-IDA21282530  
GO:0005654nucleoplasm-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0009898cytoplasmic side of plasma membrane-IBA21873635  
GO:0030175filopodium-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030426growth cone-IBA21873635  
GO:0031519PcG protein complex-IDA21282530  
GO:0043025neuronal cell body-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1257604PIP3 activates AKT signalingIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-6807070PTEN RegulationTAS
R-HSA-6807070PTEN RegulationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownTAS
R-HSA-8943724Regulation of PTEN gene transcriptionTAS
R-HSA-8943724Regulation of PTEN gene transcriptionIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006925Intracellular signaling by second messengersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29028944Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer. (2017 Dec 7)Selinski SCarcinogenesis