Gene: NPTXR

23467
NPR
neuronal pentraxin receptor
protein-coding
22q13.1
Ensembl:ENSG00000221890 MIM:609474 Vega:OTTHUMG00000150458 UniprotKB:O95502
NC_000022.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.430e-1 (AD)  5.413e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7288826chr22:38818769 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LINGO10.941
DIRAS10.939
CAMKK20.937
CHD50.934
ATXN7L30.934
SEPT30.93
RAB150.929
IQSEC30.929
OLFM10.929
CDK160.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.582
OR4F29-0.533
SNHG18-0.504
ACAP1-0.487
SH2D1A-0.479
REST-0.476
CLEC2B-0.471
C1orf87-0.47
SGMS2-0.463
RAI14-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NPTXR mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTXR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTXR mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NPTXR mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of NPTXR mRNA28959563
D000638AmiodaroneAmiodarone results in increased expression of NPTXR mRNA19774075
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NPTXR mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of NPTXR mRNA25181051
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of NPTXR mRNA18636392
D003042CocaineCocaine results in decreased expression of NPTXR mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of NPTXR mRNA]18355967
D003042CocaineCocaine results in decreased expression of NPTXR mRNA16076954
D003471CuprizoneCuprizone results in decreased expression of NPTXR mRNA26577399
D016572CyclosporineCyclosporine affects the expression of NPTXR mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of NPTXR mRNA27989131
C023614dibenzofurandibenzofuran analog results in increased expression of NPTXR mRNA20566336
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NPTXR mRNA20823114
D002945CisplatinCisplatin results in increased expression of NPTXR mRNA22023808
C118739entinostatentinostat results in increased expression of NPTXR mRNA27188386
D000431EthanolEthanol affects the expression of NPTXR mRNA11772933
D000431EthanolEthanol results in increased expression of NPTXR mRNA17920746
D005839GentamicinsGentamicins results in decreased expression of NPTXR mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NPTXR mRNA24796395|2675264
D007854LeadLead affects the expression of NPTXR mRNA28903495
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of NPTXR mRNA20823114
D008727MethotrexateMethotrexate results in increased expression of NPTXR mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NPTXR mRNA"25554681
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of NPTXR mRNA18636392
D010269ParaquatParaquat results in increased expression of NPTXR mRNA18198484
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NPTXR mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NPTXR mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of NPTXR mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of NPTXR mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NPTXR mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of NPTXR gene28589171
D013605T-2 ToxinT-2 Toxin results in decreased expression of NPTXR mRNA26141394
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of NPTXR mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of NPTXR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NPTXR mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of NPTXR mRNA23179753|2800136
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of NPTXR mRNA25423262

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0031175neuron projection development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0009898cytoplasmic side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0030175filopodium-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030426growth cone-IBA21873635  
GO:0043025neuronal cell body-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal