Gene: CBX5

23468
HEL25|HP1|HP1A
chromobox 5
protein-coding
12q13.13
Ensembl:ENSG00000094916 MIM:604478 Vega:OTTHUMG00000169700 UniprotKB:P45973
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.375e-1 (AD)  9.083e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19641804chr12:54653065CBX51.600e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAQ0.89
PUM10.885
PUM20.873
XIAP0.871
ADNP0.865
ZBTB40.865
SNX270.864
HUWE10.863
ZMYM40.861
NCOA10.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.746
OR4F29-0.719
CSAG1-0.243
TFPI2-0.232
PDZK1IP1-0.227
HMHB1-0.222
NKX6-1-0.211
CLEC6A-0.21
TCF15-0.2
NCCRP1-0.2

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CBX5 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CBX5 mRNA"23962555
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CBX5 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CBX5 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CBX5 mRNA17562736
D001280AtrazineAtrazine results in increased expression of CBX5 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of CBX5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CBX5 mRNA21632981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CBX5 mRNA"20018196|2038263
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of CBX5 mRNA"20162321
C006780bisphenol Abisphenol A affects the expression of CBX5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CBX5 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CBX5 mRNA22687993
C006780bisphenol Abisphenol A affects the expression of CBX5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CBX5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CBX5 gene28505145
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CBX5 protein23535288
C018475butyraldehydebutyraldehyde results in decreased expression of CBX5 mRNA26079696
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA]"20230807
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CBX5 mRNA26272509
C018021cobaltous chloridecobaltous chloride results in decreased expression of CBX5 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CBX5 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CBX5 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of CBX5 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CBX5 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CBX5 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CBX5 mRNA20106945
D003703DemecolcineDemecolcine results in decreased expression of CBX5 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of CBX5 protein23811945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CBX5 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CBX5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CBX5 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CBX5 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CBX5 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CBX5 mRNA]17854601
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of CBX5 mRNA27638505
C012301domoic aciddomoic acid results in decreased expression of CBX5 mRNA18936300
C118739entinostatentinostat results in decreased expression of CBX5 mRNA27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CBX5 protein23301498
D000431EthanolEthanol results in decreased expression of CBX5 mRNA28986285
D005273FenbendazoleFenbendazole results in increased expression of CBX5 protein23411599
D005557FormaldehydeFormaldehyde results in decreased expression of CBX5 mRNA23649840
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of CBX5 protein]20884965
D019833GenisteinGenistein results in increased expression of CBX5 protein20884965
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CBX5 mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CBX5 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CBX5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CBX5 mRNA22802445
C017461lead nitrate[nickel chloride co-treated with lead nitrate] results in increased expression of CBX5 mRNA19187980
C045463leflunomideleflunomide results in increased expression of CBX5 mRNA28988120
C005223methyleugenolmethyleugenol results in increased expression of CBX5 protein23411599
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CBX5 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CBX5 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CBX5 mRNA"26251327
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of CBX5 mRNA12634122
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA]"20230807
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CBX5 mRNA"25620056
C022838nickel chloride[nickel chloride co-treated with lead nitrate] results in increased expression of CBX5 mRNA19187980
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CBX5 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA]"20230807
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CBX5 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CBX5 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CBX5 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in decreased expression of CBX5 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CBX5 protein26178269
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CBX5 mRNA26678675
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CBX5 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of CBX5 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of CBX5 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CBX5 mRNA19162173
D011794QuercetinQuercetin results in increased expression of CBX5 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CBX5 mRNA19167446
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CBX5 mRNA19244175
D012643SeleniumSelenium results in decreased expression of CBX5 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CBX5 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of CBX5 mRNA17879257
C017947sodium arsenitesodium arsenite results in increased expression of CBX5 mRNA28595984
C004648testosterone enanthatetestosterone enanthate affects the expression of CBX5 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CBX5 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CBX5 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of CBX5 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of CBX5 protein23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CBX5 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CBX5 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CBX5 protein16569592
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CBX5 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CBX5 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CBX5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CBX5 mRNA28973697
D014520UrethaneUrethane results in decreased expression of CBX5 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CBX5 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CBX5 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CBX5 gene25560391
D014750VincristineVincristine results in decreased expression of CBX5 mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CBX5 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of CBX5 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of CBX5 mRNA27188386
C111237vorinostatvorinostat results in increased expression of CBX5 protein20543569
C088658zoledronic acidzoledronic acid results in increased expression of CBX5 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0005515protein binding-IPI8663349  9636146  9636147  9864353  10330177  10699177  
12711603  15502821  15882967  16189514  16415788  18716626  
19498464  19617346  19666599  19834512  20042602  20562864  
20850016  20871592  21346195  21888893  21900206  23797873  
24018422  25931448  27107012  27705803  
GO:0030674protein binding, bridging-ISS-  
GO:0035064methylated histone binding-IDA19783980  21029866  
GO:0042802identical protein binding-IPI18716626  21888893  
GO:0042803protein homodimerization activity-IEA-  
GO:0042826histone deacetylase binding-IEA-  
GO:0043021ribonucleoprotein complex binding-IDA19617346  
GO:0044877protein-containing complex binding-IDA19617346  
GO:0070491repressing transcription factor binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP19617346  
GO:0007596blood coagulation-TAS-  
GO:0016032viral process-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA9636147  
GO:0045892negative regulation of transcription, DNA-templated-IMP9636146  9636147  
GO:0070317negative regulation of G0 to G1 transition-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-ISS-  
GO:0000776kinetochore-IEA-  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0005634nucleus-IDA9636146  19617346  19783980  
GO:0005635nuclear envelope-TAS8663349  
GO:0005654nucleoplasm-TAS-  
GO:0005720nuclear heterochromatin-TAS8663349  
GO:0005721pericentric heterochromatin-ISS-  
GO:0005730nucleolus-IDA9636146  
GO:0010369chromocenter-IEA-  
GO:0016605PML bodycolocalizes_withIMP9636146  
GO:0017053transcriptional repressor complex-ISS-  
GO:0031618nuclear pericentric heterochromatin-NAS16177824  
GO:0032991protein-containing complex-IDA19617346  
GO:0035097histone methyltransferase complex-ISS-  
GO:1990904ribonucleoprotein complex-IDA19617346  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2990846SUMOylationIEA
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-4551638SUMOylation of chromatin organization proteinsIEA
R-HSA-597592Post-translational protein modificationIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953750Transcriptional Regulation by E2F6TAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29464021Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. (2018 Jan 19)Wang HOncotarget