Gene: TRAM1

23471
PNAS8|TRAM|TRAMP
translocation associated membrane protein 1
protein-coding
8q13.3
Ensembl:ENSG00000067167 MIM:605190 Vega:OTTHUMG00000164428 UniprotKB:Q15629
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.771e-1 (AD)  2.515e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAP1B0.899
SMAD50.873
KLF30.863
MCMBP0.863
TMOD30.858
ATL30.856
BNIP20.855
TROVE20.849
MOB1A0.846
LMAN10.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.388
OR4F29-0.386
SPEF1-0.384
KCNG2-0.377
GSG1-0.372
DLK2-0.37
PIP5KL1-0.365
ABCC12-0.363
ADRA1D-0.361
NKX6-3-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TRAM1 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TRAM1 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of TRAM1 mRNA"15215175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TRAM1 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRAM1 mRNA27153756
C547126AZM551248AZM551248 results in increased expression of TRAM1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TRAM1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAM1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TRAM1 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of TRAM1 mRNA17823450
D004958EstradiolEstradiol results in decreased expression of TRAM1 mRNA20068009
C044887beta-methylcholinebeta-methylcholine affects the expression of TRAM1 mRNA21179406
C053541bicalutamidebicalutamide results in increased expression of TRAM1 mRNA16631469
D001647Bile Acids and SaltsBile Acids and Salts results in increased expression of TRAM1 mRNA18556422
C006780bisphenol Abisphenol A affects the expression of TRAM1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TRAM1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TRAM1 mRNA15336504
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TRAM1 mRNA23650126
C100187chloropicrinchloropicrin affects the expression of TRAM1 mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of TRAM1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAM1 mRNA19549813
C030973cupric oxidecupric oxide results in decreased expression of TRAM1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased methylation of TRAM1 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of TRAM1 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of TRAM1 mRNA25270620
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TRAM1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TRAM1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TRAM1 mRNA16061661|2739243
C000944dicrotophosdicrotophos results in decreased expression of TRAM1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of TRAM1 mRNA18042831|1903023
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of TRAM1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of TRAM1 mRNA26846883
D007213IndomethacinIndomethacin results in decreased expression of TRAM1 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TRAM1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TRAM1 mRNA27392435
C011890kojic acidkojic acid results in decreased expression of TRAM1 mRNA16595896
D008627Mercuric ChlorideMercuric Chloride affects the expression of TRAM1 mRNA20353558
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAM1 mRNA23649840
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of TRAM1 mRNA12634122
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TRAM1 mRNA"25554681
D009532NickelNickel results in increased expression of TRAM1 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of TRAM1 mRNA24612858
D000073878Palm OilPalm Oil results in increased expression of TRAM1 mRNA18042831
D010795Phthalic AcidsPhthalic Acids results in increased expression of TRAM1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of TRAM1 mRNA23811191
C045950propiconazolepropiconazole results in increased expression of TRAM1 mRNA21278054
C059514resveratrolresveratrol results in increased expression of TRAM1 protein25505154
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TRAM1 mRNA"16251409
C017947sodium arsenitesodium arsenite results in decreased expression of TRAM1 mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAM1 mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of TRAM1 mRNA22378314
D013849ThimerosalThimerosal results in increased expression of TRAM1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of TRAM1 mRNA27760801
D014415TunicamycinTunicamycin results in increased expression of TRAM1 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of TRAM1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of TRAM1 gene29154799
C111237vorinostatvorinostat results in increased expression of TRAM1 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of TRAM1 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18555783  
GO:0038023signaling receptor activity-TAS1315422  
GO ID GO Term Qualifier Evidence PubMed
GO:0006613cotranslational protein targeting to membrane-TAS1315422  
GO:0007165signal transduction-IEA-  
GO:0016032viral process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA18555783  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005791rough endoplasmic reticulum-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-1799339SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-392499Metabolism of proteinsIEA
R-HSA-72766TranslationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14557830Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. (2004 Jan)Wasserman LInt J Obes Relat Metab Disord