Gene: BRD4

23476
CAP|HUNK1|HUNKI|MCAP
bromodomain containing 4
protein-coding
19p13.12
Ensembl:ENSG00000141867 MIM:608749 Vega:OTTHUMG00000183252 UniprotKB:O60885
NC_000019.10
PubMed
CD|ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.994e-1 (AD)  1.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FURIN0.887
CREBBP0.88
KHSRP0.877
PHRF10.876
SCAF40.873
BAHD10.872
ATXN2L0.87
CHERP0.867
DPP90.867
FAM193A0.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.618
OR4F29-0.579
CTNNA3-0.267
KLRC2-0.262
TSPAN8-0.253
PDE11A-0.25
CDNF-0.25
CHP2-0.247
GSDMC-0.244
LRRCC1-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0889691,4-diaminocyclohexane"1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]"24973920
C0889691,4-diaminocyclohexane"1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI2 protein]"24973920
C0889691,4-diaminocyclohexane"BRD4 mutant form inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI1 mRNA]"24973920
C0889691,4-diaminocyclohexane"BRD4 mutant form inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of GLI2 mRNA]"24973920
C0889691,4-diaminocyclohexane"BRD4 mutant form inhibits the reaction [1,4-diaminocyclohexane analog results in increased expression of PTCH1 mRNA]"24973920
C0889691,4-diaminocyclohexane"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]]"24973920
C0889691,4-diaminocyclohexane"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI2 protein]]"24973920
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BRD4 mRNA"27291303
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of BRD4 mRNA"20206263
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [TNF protein promotes the reaction [BRD4 protein binds to CCL2 enhancer]]25263595
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [TNF protein promotes the reaction [BRD4 protein binds to VCAM1 enhancer]]25263595
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BRD4 mRNA"18648102
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]"26301327
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]"26301327
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]"26301327
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [BDNF protein results in increased phosphorylation of BRD4 protein]"26301327
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of BRD4 mRNA"28073004
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"BRD4 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]"26212199
D000082AcetaminophenAcetaminophen results in decreased expression of BRD4 mRNA26690555
D000086AcetazolamideAcetazolamide results in increased expression of BRD4 mRNA19274763
D000276Adjuvants, Immunologic"Adjuvants, Immunologic results in increased expression of BRD4 mRNA"25656449
D013196DihydrotestosteroneDihydrotestosterone affects the localization of BRD4 protein24759320
D013196Dihydrotestosterone(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone affects the localization of BRD4 protein]24759320
C000606252ARV-825ARV-825 results in increased degradation of BRD4 protein26051217
C000606252ARV-825benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
C000606252ARV-825carfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
C000606252ARV-825pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
D001241AspirinAspirin results in increased expression of BRD4 mRNA11906190
D001280AtrazineAtrazine results in decreased expression of BRD4 mRNA25929836
D001280AtrazineAtrazine results in increased expression of BRD4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BRD4 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [BRD4 mutant form affects the localization of RELA protein]23686307
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]]25877301
C006780bisphenol Abisphenol A affects the expression of BRD4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of BRD4 mRNA25181051
C584509C646 compoundC646 compound inhibits the reaction [BRD4 protein binds to CDK6 promoter]25982114
C584509C646 compoundC646 compound inhibits the reaction [BRD4 protein binds to MYC enhancer]25982114
C584509C646 compoundC646 compound inhibits the reaction [BRD4 protein binds to MYC promoter]25982114
C584509C646 compoundC646 compound inhibits the reaction [BRD4 protein binds to PECAM1 promoter]25982114
C524865carfilzomibcarfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
D002108Ceruletide(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]26390243
D002108Ceruletide[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein26390243
D002737ChloropreneChloroprene results in increased expression of BRD4 mRNA23125180
C007095cobaltiprotoporphyrinBRD4 mutant form promotes the reaction [cobaltiprotoporphyrin promotes the reaction [NFE2L2 protein binds to HMOX1 enhancer]]24763052
C007095cobaltiprotoporphyrinBRD4 mutant form promotes the reaction [cobaltiprotoporphyrin results in increased expression of and affects the localization of NFE2L2 protein]24763052
C007095cobaltiprotoporphyrinBRD4 mutant form promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 mRNA]24763052
C007095cobaltiprotoporphyrinBRD4 mutant form promotes the reaction [cobaltiprotoporphyrin results in increased expression of HMOX1 protein]24763052
D003042CocaineCocaine promotes the reaction [BRD4 protein binds to BDNF promoter]26558777
D003042CocaineCocaine results in increased expression of BRD4 protein26558777
D003042Cocaine(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]26558777
D003042CocaineCocaine results in increased expression of BRD4 protein26558777
D016572CyclosporineCyclosporine results in increased expression of BRD4 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of BRD4 mRNA23640034
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of BRD4 mRNA"25908611
D002945CisplatinCisplatin results in decreased expression of BRD4 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of BRD4 mRNA28302478
D004237DiuronDiuron results in decreased expression of BRD4 mRNA25152437
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of BRD4 protein23301498
D000068338Everolimus[MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene]25537515
D005485FlutamideFlutamide results in increased expression of BRD4 mRNA20566332
D005839GentamicinsGentamicins results in decreased expression of BRD4 mRNA22061828
C010974glyphosateglyphosate results in increased expression of BRD4 mRNA26302742
C568713GSK1210151AGSK1210151A inhibits the reaction [[Lipopolysaccharides results in increased acetylation of RELA protein] which binds to BRD4 protein]25778533
D006861Hydrogen PeroxideBRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of CXCL8 protein]]24759736
D006861Hydrogen PeroxideBRD4 mutant form inhibits the reaction [Hydrogen Peroxide promotes the reaction [IL1B protein results in increased expression of IL6 protein]]24759736
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]24759736
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]24759736
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to CXCL8 promoter]]24759736
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [IL1B protein promotes the reaction [BRD4 protein binds to IL6 promoter]]24759736
D006861Hydrogen Peroxide(+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]]24759736
D006861Hydrogen Peroxide(+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]]24759736
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of BRD4 mRNA19376150
D007545IsoproterenolIsoproterenol results in decreased expression of BRD4 mRNA20003209
C561695(+)-JQ1 compoundBRD4 protein modified form affects the susceptibility to (+)-JQ1 compound26735014
C561695(+)-JQ1 compound(+)-JQ1 compound affects the localization of BRD4 protein22952229
C561695(+)-JQ1 compound(+)-JQ1 compound analog binds to BRD4 protein24972113
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of BRD4 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in decreased expression of BRD4 protein25989842
C561695(+)-JQ1 compound(+)-JQ1 compound analog results in increased expression of BRD4 mRNA25989842
C561695(+)-JQ1 compound(+)-JQ1 compound binds to BRD4 protein20871596|2449763
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to AR protein]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to BCL2L1 promoter]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to BCL2 promoter]24435446|2625444
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to BCL6 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CCND2 enhancer alternative form]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CDK6 promoter]24435446
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to COL1A1 enhancer]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to E2F2 promoter]27081696
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to EWSR1 promoter]27006472
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to FOSL1 promoter]25944566
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to FOSL2 gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IGH enhancer]21889194
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IL2RA gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IL6 promoter]26390243
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IL7R promoter]22904298
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IRF8 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MAL gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MED1 protein]26735014
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MYC enhancer]26254443
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MYC enhancer alternative form]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MYCN promoter]23430699
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to MYC promoter]21949397|2290429
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to PAX5 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to POU2AF1 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to RUNX2 gene]25944566
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to RUNX2 promoter]25307878
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SMARCA4 enhancer]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SMARCA4 promoter]23582323
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SOX2 enhancer]24736545
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to SOX2 promoter]24736545
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to TGFBR2 promoter]27432991
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to AR protein]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to AR protein modified form]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to SOX2 enhancer]24736545
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein modified form binds to SOX2 promoter]24736545
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Dihydrotestosterone affects the localization of BRD4 protein]24759320
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [EP300 protein promotes the reaction [RELA protein modified form binds to BRD4 protein]]23686307
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [ERG protein binds to BRD4 protein]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GNAQ gene mutant form promotes the reaction [BRD4 protein binds to BCL2L1 promoter]]26397223
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [GNAQ gene mutant form promotes the reaction [BRD4 protein binds to RAD51 promoter]]26397223
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to CXCL8 promoter]]24759736
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Hydrogen Peroxide co-treated with IL1B protein] promotes the reaction [BRD4 protein binds to IL6 promoter]]24759736
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [RELA protein modified form binds to BRD4 protein]23686307
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNF protein promotes the reaction [BRD4 protein binds to CCL2 enhancer]]25263595
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNF protein promotes the reaction [BRD4 protein binds to VCAM1 enhancer]]25263595
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to MMP9 promoter]]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24646477
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [BRD4 protein binds to CDK9 protein]22952229
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BRD4 protein23582323|2598984
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of BRD4 protein26051217|2637803
C561695(+)-JQ1 compound[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which affects the localization of BRD4 protein24045185
C561695(+)-JQ1 compoundtetraarsenic tetrasulfide promotes the reaction [(+)-JQ1 compound results in decreased expression of BRD4 protein]26586936
C561695(+)-JQ1 compoundBRD4 mutant form inhibits the reaction [(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in decreased expression of CDKN1A mRNA]]25877301
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to ARC promoter]]26301327
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to FOS promoter]]26301327
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BDNF protein promotes the reaction [BRD4 protein binds to NR4A1 promoter]]26301327
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CEBPA enhancer]26117538
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CEBPA gene]26117538
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to GLI1 promoter]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to GLI2 promoter]24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to PPARG enhancer]26117538
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to PPARG gene]26117538
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]26558777
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [FAS gene mutant form results in increased expression of BRD4 protein]26590112
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [BRD4 protein binds to IFIT1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [BRD4 protein binds to ISG15 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [IFNB1 protein promotes the reaction [BRD4 protein binds to MX1 promoter]]23589332
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[KRAS mutant form co-treated with TRP53 mutant form] results in increased expression of BRD4 protein]26390243
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]26390243
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to IL6 promoter]]"23420887
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to TNF promoter]]"24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [PDK1 gene mutant form promotes the reaction [BRD4 protein binds to MYC promoter]]25877301
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to BTK promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to CCL4 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to FCGR2B promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 enhancer]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[SP11 protein co-treated with FLI1 protein co-treated with ERG protein co-treated with CEBPB protein co-treated with MYB protein co-treated with BRD4 protein] binds to PECAM1 promoter]25982114
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to FOS promoter]]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TNFSF11 protein promotes the reaction [BRD4 protein binds to NFATC1 promoter]]24799421
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased activity of BRD4 protein25383670
C561695(+)-JQ1 compound[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased expression of BRD4 protein24045185
C561695(+)-JQ1 compoundSTK11 gene mutant form affects the reaction [[KRAS gene mutant form results in increased susceptibility to (+)-JQ1 compound] which results in increased expression of BRD4 protein]24045185
C561695(+)-JQ1 compound(+)-JQ1 compound affects the reaction [BRD4 protein binds to CCND1 promoter]27440272
C561695(+)-JQ1 compound(+)-JQ1 compound affects the reaction [BRD4 protein binds to MYC promoter]27440272
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI1 protein]]"24973920
C561695(+)-JQ1 compound"(+)-JQ1 compound inhibits the reaction [1,4-diaminocyclohexane analog promotes the reaction [BRD4 protein binds to GLI2 protein]]"24973920
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to ASCL1 enhancer]26253517
C045463leflunomideleflunomide results in increased expression of BRD4 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"BRD4 mutant form inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]]"26212199
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CCL2 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of IL6 protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF mRNA]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"BRD4 mutant form affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of TNF protein]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to IL6 promoter]]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"(+)-JQ1 compound inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to TNF promoter]]"24799421
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to IL6 promoter]"23420887
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [BRD4 protein binds to TNF promoter]"24799421
D008070LipopolysaccharidesGSK1210151A inhibits the reaction [[Lipopolysaccharides results in increased acetylation of RELA protein] which binds to BRD4 protein]25778533
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of BRD4 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BRD4 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of BRD4 mRNA27544571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BRD4 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of BRD4 mRNA29191790
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of BRD4 mRNA20024957
C025589ochratoxin Aochratoxin A results in increased expression of BRD4 mRNA22124623
D053683Oncostatin MOncostatin M promotes the reaction [BRD4 protein binds to SOCS3 promoter]24657799
D053683Oncostatin MSTAT3 protein affects the reaction [Oncostatin M promotes the reaction [BRD4 protein binds to SOCS3 promoter]]24657799
C000605331OTX015OTX015 results in increased expression of BRD4 protein26051217
D010100OxygenOxygen deficiency promotes the reaction [BRD4 protein binds to CA9 promoter]27292261
D010100OxygenOxygen deficiency promotes the reaction [BRD4 protein binds to VEGFA promoter]27292261
D010100OxygenOxygen deficiency results in increased expression of BRD427292261
D010100OxygenOxygen deficiency results in increased expression of BRD4 mRNA24205000
D010416PentachlorophenolPentachlorophenol results in increased expression of BRD4 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of BRD4 protein26879310
C031637phenothiazinephenothiazine inhibits the reaction [BRD4 protein binds to MED1 protein]26735014
D010656PhenylephrinePhenylephrine promotes the reaction [BRD4 protein binds to NPPA promoter]23939492
D010656PhenylephrinePhenylephrine results in increased expression of BRD4 protein23939492
C006253pirinixic acidpirinixic acid results in increased expression of BRD4 mRNA18445702
C467566pomalidomidepomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein]26051217
D011441PropylthiouracilPropylthiouracil results in decreased expression of BRD4 mRNA24780913
D012715Sesame OilSesame Oil results in decreased expression of BRD4 mRNA29191790
D012999SomanSoman results in increased expression of BRD4 mRNA19281266
C533237STA 9090benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]]25877301
C533237STA 9090STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]25877301
D013467SulindacSulindac results in decreased expression of BRD4 mRNA11906190
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [(+)-JQ1 compound results in decreased expression of BRD4 protein]26586936
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BRD4 mRNA21570461|2468072
C012589trichostatin Atrichostatin A results in decreased expression of BRD4 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BRD4 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of BRD4 mRNA28973697
D014520UrethaneUrethane results in increased expression of BRD4 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of BRD4 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of BRD4 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of BRD4 mRNA17292431
C025643vinclozolinvinclozolin affects the expression of BRD4 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of BRD4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000993RNA polymerase II core binding-IDA22509028  
GO:0002039p53 binding-IDA23317504  
GO:0003682chromatin binding-IDA20871596  23086925  23317504  
GO:0005515protein binding-IPI15109495  17023018  17189189  17474147  18305892  19103749  
22645123  22761572  23455924  23686307  24360279  24525235  
GO:0070577lysine-acetylated histone binding-IDA20871596  23086925  23317504  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-IMP18039861  
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IMP10938129  
GO:0016032viral process-IEA-  
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter-IDA19103749  23086925  
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter-IMP18039861  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA19103749  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA23086925  23317504  
GO:0050727regulation of inflammatory response-IDA19103749  
GO:1901407regulation of phosphorylation of RNA polymerase II C-terminal domain-IDA23086925  
GO ID GO Term Qualifier Evidence PubMed
GO:0000794condensed nuclear chromosome-IDA10938129  
GO:0005634nucleus-IDA20871596  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26001144Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. (2015 Jun)Sholl LMJ Thorac Oncol
15994877Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S phase in vitro. (2005 Jul)Haruki NJ Med Genet
26558777Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. (2015 Nov 11)Sartor GCJ Neurosci