Gene: FOLR1

2348
FBP|FOLR
folate receptor 1
protein-coding
11q13.4
Ensembl:ENSG00000110195 MIM:136430 Vega:OTTHUMG00000167876 UniprotKB:P15328
NG_015863.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.743e-1 (AD)  3.437e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOGA10.684
CYP11A10.677
ACSF20.67
CCDC80.669
FAH0.668
GPR1430.664
ENTPD20.659
TNFSF130.638
MMP280.637
CLDN100.635

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST2-0.465
OSBPL10-0.441
DPP4-0.44
M1AP-0.437
SMPX-0.424
FSTL4-0.415
RYR2-0.413
RXFP1-0.411
LRMP-0.409
FHL2-0.408

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalTarget
DB05168VintafolideSmall Molecule742092-03-1InvestigationalTarget
DB05595FarletuzumabBiotechDrug896723-44-7InvestigationalTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of FOLR1 mRNA"22101062
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FOLR1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of FOLR1 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOLR1 mRNA"27188386
C0059845-methyltetrahydrofolateFOLR1 protein results in increased uptake of 5-methyltetrahydrofolate17473184
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOLR1 mRNA"27188386
C496492abrineabrine results in increased expression of FOLR1 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of FOLR1 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of FOLR1 mRNA29067470
D000452AldrinAldrin results in increased expression of FOLR1 mRNA18579281
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of FOLR1 mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of FOLR1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FOLR1 mRNA16483693
D001280AtrazineAtrazine results in increased expression of FOLR1 mRNA22378314
D001397AzoxymethaneFOLR1 gene mutant form results in increased susceptibility to Azoxymethane15705887
C487081belinostatbelinostat results in decreased expression of FOLR1 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOLR1 mRNA27195522
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of FOLR1 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FOLR1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of FOLR1 mRNA19619570
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of FOLR1 mRNA18692832
C504662BGC945BGC945 binds to FOLR1 protein16357184
C504662BGC945BGC945 binds to FOLR1 protein16357184
C004541biochanin Abiochanin A results in decreased expression of FOLR1 mRNA12111696
C006780bisphenol Abisphenol A results in decreased expression of FOLR1 mRNA19371625
C006780bisphenol Abisphenol A results in increased expression of FOLR1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of FOLR1 mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of FOLR1 mRNA22956110
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FOLR1 mRNA14729362|1500399
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FOLR1 mRNA17484886
D002746ChlorpromazineChlorpromazine affects the expression of FOLR1 mRNA25064622
D002922CiguatoxinsCiguatoxins affects the expression of FOLR1 mRNA18353800
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of FOLR1 mRNA15467011
D003471CuprizoneCuprizone results in increased expression of FOLR1 mRNA26577399|2752363
D016572CyclosporineCyclosporine affects the expression of FOLR1 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of FOLR1 mRNA20106945|2798913
D003976DiazinonDiazinon results in decreased expression of FOLR1 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FOLR1 mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of FOLR1 mRNA19371625
D004317DoxorubicinDoxorubicin results in decreased expression of FOLR1 mRNA16404146
D004317DoxorubicinFOLR1 protein results in decreased susceptibility to Doxorubicin15634643
D000431EthanolEthanol results in decreased expression of FOLR1 mRNA17531458
D000431EthanolEthanol results in increased expression of FOLR1 mRNA19616087
D000431EthanolEthanol results in increased expression of FOLR1 protein17449590
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOLR1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOLR1 mRNA23300682
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FOLR1 mRNA15834898|1755790
D015025ZearalenoneZearalenone results in decreased expression of FOLR1 mRNA19371625
D005419FlavonoidsFlavonoids results in decreased expression of FOLR1 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of FOLR1 mRNA16510598
D005480FlurbiprofenFlurbiprofen results in decreased expression of FOLR1 mRNA16949054
D005492Folic AcidFolic Acid affects the expression of FOLR1 mRNA17311948
D005492Folic AcidFolic Acid binds to FOLR1 protein21879757
D005492Folic AcidFolic Acid deficiency results in decreased expression of FOLR1 mRNA20465997
D005492Folic Acid"Folic Acid inhibits the reaction [FOLR1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid]"21879757
D005492Folic AcidFolic Acid results in decreased expression of FOLR1 mRNA17616776
D005492Folic AcidFOLR1 gene mutant form results in decreased abundance of Folic Acid19732866
D005492Folic AcidFOLR1 protein results in increased transport of Folic Acid19732866
D005492Folic Acid"N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid inhibits the reaction [Folic Acid binds to FOLR1 protein]"21879757
D005492Folic AcidFOLR1 protein affects the abundance of Folic Acid15705887
D005492Folic AcidFOLR1 protein results in increased uptake of Folic Acid14581169
D005492Folic AcidRFC1 protein mutant form promotes the reaction [FOLR1 protein mutant form results in decreased abundance of Folic Acid]18926688
D005492Folic AcidFolic Acid results in decreased expression of FOLR1 protein17482424
D005492Folic AcidFolic Acid inhibits the reaction [FOLR1 protein binds to and results in increased import of lometrexol]16740727
D005620Freund's AdjuvantFreund's Adjuvant promotes the reaction [Urethane results in decreased expression of FOLR1 mRNA]12810352
D005620Freund's Adjuvant[Urethane co-treated with Freund's Adjuvant] results in increased expression of FOLR1 mRNA12400877
C069837fullerene C60fullerene C60 results in decreased expression of FOLR1 mRNA19167457
D019833GenisteinGenistein results in decreased expression of FOLR1 mRNA19371625
D005947GlucoseGlucose results in decreased expression of FOLR1 mRNA19616087
C004312glycidolglycidol results in increased expression of FOLR1 mRNA24915197
D006493HeparinFOLR1 protein binds to Heparin16470783
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FOLR1 mRNA20044591
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FOLR1 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FOLR1 mRNA14729362
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOLR1 mRNA26644586
C008261lead acetatelead acetate affects the expression of FOLR1 mRNA21864555|2264161
C045894lometrexolFolic Acid inhibits the reaction [FOLR1 protein binds to and results in increased import of lometrexol]16740727
C045894lometrexolFOLR1 protein binds to and results in increased import of lometrexol16740727
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FOLR1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOLR1 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of FOLR1 mRNA27167697
D009151Mustard GasMustard Gas results in increased expression of FOLR1 mRNA25102026
C568952N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"Folic Acid inhibits the reaction [FOLR1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid]"21879757
C568952N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"FOLR1 protein results in increased susceptibility to N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"21879757
C568952N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid"N-((5-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)propyl)thiophen-2-yl)carbonyl)glutamic acid inhibits the reaction [Folic Acid binds to FOLR1 protein]"21879757
D009532NickelNickel results in decreased expression of FOLR1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of FOLR1 mRNA19167457
D009538NicotineNicotine results in increased expression of FOLR1 mRNA19616087
C016340o,p'-DDT"o,p'-DDT results in decreased expression of FOLR1 mRNA"19371625
D010269ParaquatParaquat affects the expression of FOLR1 mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FOLR1 mRNA"25510870
C046012pentanalpentanal results in increased expression of FOLR1 mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of FOLR1 mRNA18692542
C031181phenanthrenephenanthrene results in increased expression of FOLR1 mRNA19457238
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FOLR1 mRNA15728792
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of FOLR1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of FOLR1 mRNA18692832
D011374ProgesteroneProgesterone results in decreased expression of FOLR1 mRNA19690047
C068874raltitrexedFOLR1 protein results in increased susceptibility to raltitrexed21879757
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of FOLR1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FOLR1 mRNA25895662
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of FOLR1 mRNA]21245298
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FOLR1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FOLR1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOLR1 mRNA22298810
D013752TetracyclineTetracycline affects the expression of FOLR1 mRNA25064622
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FOLR1 protein18951874
D013849ThimerosalThimerosal results in decreased expression of FOLR1 mRNA24675092
D013853ThioacetamideThioacetamide affects the expression of FOLR1 mRNA25064622
D014118Toxins, Biological"Toxins, Biological affects the expression of FOLR1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of FOLR1 mRNA16604517
D014241TrichloroethyleneTrichloroethylene affects the expression of FOLR1 mRNA21135412
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FOLR1 gene27618143
D014520UrethaneFreund's Adjuvant promotes the reaction [Urethane results in decreased expression of FOLR1 mRNA]12810352
D014520Urethane[Urethane co-treated with Freund's Adjuvant] results in increased expression of FOLR1 mRNA12400877
D014520UrethaneUrethane results in increased expression of FOLR1 mRNA12400877
D014635Valproic AcidValproic Acid affects the expression of FOLR1 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOLR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FOLR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FOLR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of FOLR1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of FOLR1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of FOLR1 mRNA9188671
D014635Valproic AcidValproic Acid results in decreased expression of FOLR1 mRNA19136453|2054688
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FOLR1 gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of FOLR1 mRNA18579281
C088658zoledronic acidzoledronic acid results in decreased expression of FOLR1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005542folic acid binding-IBA21873635  
GO:0005542folic acid binding-IDA2527252  10787414  14722620  23851396  
GO:0005542folic acid binding-NAS1840502  
GO:0008144drug binding-IPI19116913  
GO:0038023signaling receptor activity-TAS10633085  
GO:0051870methotrexate binding-IDA19116913  
GO:0061714folic acid receptor activity-IC10787414  
GO:0061714folic acid receptor activity-IMP8033114  
GO ID GO Term Qualifier Evidence PubMed
GO:0001947heart looping-ISS-  
GO:0003147neural crest cell migration involved in heart formation-ISS-  
GO:0003253cardiac neural crest cell migration involved in outflow tract morphogenesis-ISS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0006898receptor-mediated endocytosis-TAS9545095  
GO:0007165signal transduction-IEA-  
GO:0015884folic acid transport-IMP8033114  
GO:0017015regulation of transforming growth factor beta receptor signaling pathway-ISS-  
GO:0031103axon regeneration-ISS-  
GO:0046655folic acid metabolic process-IEA-  
GO:0048208COPII vesicle coating-TAS-  
GO:0060828regulation of canonical Wnt signaling pathway-ISS-  
GO:0061626pharyngeal arch artery morphogenesis-ISS-  
GO:0061713anterior neural tube closure-ISS-  
GO:0071231cellular response to folic acid-IDA14722620  
GO:1904447folate import across plasma membrane-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005634nucleus-IDA23243496  
GO:0005768endosome-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-NAS1840502  
GO:0009986cell surface-HDA19581412  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0016020membrane-TAS10633085  
GO:0016323basolateral plasma membrane-IDA10787414  
GO:0016324apical plasma membrane-IDA10787414  
GO:0030133transport vesicle-TAS-  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0031362anchored component of external side of plasma membrane-IBA21873635  
GO:0031362anchored component of external side of plasma membrane-IDA2527252  8033114  
GO:0031526brush border membrane-IEA-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0070062extracellular exosome-HDA19199708  23533145  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23598597The dormant and the fully competent oocyte: comparing the transcriptome of human oocytes from primordial follicles and in metaphase II. (2013 Sep)Grondahl MLMol Hum Reprod