Gene: HEY2

23493
CHF1|GRIDLOCK|GRL|HERP1|HESR2|HRT2|bHLHb32
hes related family bHLH transcription factor with YRPW motif 2
protein-coding
6q22.31
Ensembl:ENSG00000135547 MIM:604674 Vega:OTTHUMG00000015512 UniprotKB:Q9UBP5
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.045e-1 (AD)  2.380e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES10.795
HDAC10.769
BAMBI0.762
REST0.755
CPQ0.753
FAM114A10.75
KANK20.749
ACTL6A0.745
TCF7L10.744
HMG20B0.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN2B-0.658
KCNB2-0.652
CDCA5-0.652
CALHM1-0.649
MLIP-0.647
KCNS2-0.643
AGBL4-0.641
PTPN3-0.64
STYK1-0.638
FAM19A1-0.637

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of HEY2 mRNA21420995|2669055
D020106AcrylamideAcrylamide results in decreased expression of HEY2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HEY2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of HEY2 mRNA"19936710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HEY2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HEY2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of HEY2 mRNA24019935
C006632arsenic trioxidearsenic trioxide results in decreased expression of HEY2 mRNA26705709
D001280AtrazineAtrazine results in increased expression of HEY2 mRNA25929836
C006680baicaleinbaicalein results in increased expression of HEY2 mRNA19160421
C006680baicalein"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]"19160421
C038044baicalinbaicalin results in increased expression of HEY2 mRNA19160421
C038044baicalin"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]"19160421
C487081belinostatbelinostat results in increased expression of HEY2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HEY2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HEY2 mRNA22228805
D004958EstradiolEstradiol results in increased expression of HEY2 mRNA21185374
D004958EstradiolRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HEY2 mRNA]21185374
C006780bisphenol Abisphenol A affects the expression of HEY2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of HEY2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of HEY2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HEY2 mRNA22079614
D002211CapsaicinCapsaicin results in increased expression of HEY2 mRNA16278290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HEY2 gene20938992
D003471CuprizoneCuprizone results in increased expression of HEY2 mRNA27523638
C014347decitabinedecitabine affects the expression of HEY2 mRNA23300844
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of HEY2 mRNA23430952
D002945CisplatinCisplatin affects the expression of HEY2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of HEY2 mRNA23625948
D004041Dietary FatsDietary Fats results in increased expression of HEY2 mRNA25016146
C118739entinostatentinostat results in increased expression of HEY2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HEY2 gene20938992
C008261lead acetatelead acetate results in increased expression of HEY2 mRNA22609695
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HEY2 mRNA"21843347
D008344Maneb[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA23017109
D008627Mercuric ChlorideMercuric Chloride affects the expression of HEY2 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of HEY2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HEY2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HEY2 mRNA"26251327
C523799MRK 003MRK 003 results in decreased expression of HEY2 mRNA21169257
C523799MRK 003MRK 003 results in decreased expression of HEY2 mRNA20197467
D009151Mustard GasMustard Gas results in increased expression of HEY2 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HEY2 mRNA"25511174
D009532NickelNickel results in decreased expression of HEY2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of HEY2 mRNA19167457
D009534NiclosamideNiclosamide results in increased expression of HEY2 mRNA19160421
D009534Niclosamide"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]"19160421
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]"19160421
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]"19160421
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]"19160421
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HEY2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of HEY2 mRNA24236059
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of HEY2 mRNA26272509
D010269Paraquat[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA23017109
D010656PhenylephrineHEY2 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]16603706
D010656PhenylephrineHEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]16603706
D010656PhenylephrineHEY2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]16603706
D010656PhenylephrineHEY2 protein results in decreased susceptibility to Phenylephrine16603706|2000186
D010656PhenylephrinePhenylephrine results in decreased expression of HEY2 mRNA16603706
D011441PropylthiouracilPropylthiouracil results in increased expression of HEY2 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HEY2 mRNA]21185374
D012906SmokeSmoke affects the expression of HEY2 mRNA23693141
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HEY2 mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HEY2 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HEY2 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HEY2 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HEY2 mRNA27913140
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HEY2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of HEY2 mRNA21934132
D014520UrethaneUrethane results in increased expression of HEY2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HEY2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HEY2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HEY2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of HEY2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of HEY2 mRNA20219112
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HEY2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding-ISS-  
GO:0000989transcription factor activity, transcription factor binding-IDA21290414  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001102RNA polymerase II activating transcription factor binding-IPI16293227  
GO:0003700DNA-binding transcription factor activity-IDA15485867  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0005515protein binding-IPI10692439  11486045  12535671  21454491  23275563  25416956  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-NAS17611704  
GO:0035939microsatellite binding-IBA21873635  
GO:0035939microsatellite binding-IDA21290414  
GO:0042803protein homodimerization activity-IEA-  
GO:0042826histone deacetylase binding-IPI12535671  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IDA11486045  
GO:0046982protein heterodimerization activity-IEA-  
GO:1990837sequence-specific double-stranded DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA10692439  12535671  16043483  16293227  21290414  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP11486045  
GO:0001568blood vessel development-IBA21873635  
GO:0001570vasculogenesis-ISS-  
GO:0003150muscular septum morphogenesis-ISS-  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0003186tricuspid valve morphogenesis-ISS-  
GO:0003195tricuspid valve formation-IEA-  
GO:0003199endocardial cushion to mesenchymal transition involved in heart valve formation-IEA-  
GO:0003208cardiac ventricle morphogenesis-ISS-  
GO:0003214cardiac left ventricle morphogenesis-ISS-  
GO:0003215cardiac right ventricle morphogenesis-ISS-  
GO:0003222ventricular trabecula myocardium morphogenesis-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-ISS-  
GO:0007507heart development-IBA21873635  
GO:0009948anterior/posterior axis specification-IEA-  
GO:0010460positive regulation of heart rate-IEA-  
GO:0010621negative regulation of transcription by transcription factor localization-ISS-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0010667negative regulation of cardiac muscle cell apoptotic process-IEA-  
GO:0014031mesenchymal cell development-ISS-  
GO:0014898cardiac muscle hypertrophy in response to stress-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0035910ascending aorta morphogenesis-ISS-  
GO:0035912dorsal aorta morphogenesis-ISS-  
GO:0036304umbilical cord morphogenesis-ISS-  
GO:0045165cell fate commitment-IEA-  
GO:0045607regulation of inner ear auditory receptor cell differentiation-IEA-  
GO:0045746negative regulation of Notch signaling pathway-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12535671  15485867  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0050767regulation of neurogenesis-IBA21873635  
GO:0051145smooth muscle cell differentiation-NAS10692439  
GO:0055015ventricular cardiac muscle cell development-ISS-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0060317cardiac epithelial to mesenchymal transition-ISS-  
GO:0060317cardiac epithelial to mesenchymal transition-TAS20951801  
GO:0060347heart trabecula formation-IEA-  
GO:0060411cardiac septum morphogenesis-ISS-  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060413atrial septum morphogenesis-ISS-  
GO:0060633negative regulation of transcription initiation from RNA polymerase II promoter-IDA10692439  
GO:0060716labyrinthine layer blood vessel development-ISS-  
GO:0060842arterial endothelial cell differentiation-ISS-  
GO:0060948cardiac vascular smooth muscle cell development-IEA-  
GO:0060977coronary vasculature morphogenesis-IEA-  
GO:0061156pulmonary artery morphogenesis-ISS-  
GO:0061314Notch signaling involved in heart development-IC12372254  
GO:0065004protein-DNA complex assembly-IEA-  
GO:0090102cochlea development-IEA-  
GO:0097084vascular smooth muscle cell development-IEP15821257  
GO:2000678negative regulation of transcription regulatory region DNA binding-IDA10692439  
GO:2000723negative regulation of cardiac vascular smooth muscle cell differentiation-ISS-  
GO:2000820negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation-ISS-  
GO:2001212regulation of vasculogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-ISS-  
GO:0016580Sin3 complexcolocalizes_withIDA11486045  
GO:0017053transcriptional repressor complex-IDA11486045  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8940973RUNX2 regulates osteoblast differentiationIEA
R-HSA-8941326RUNX2 regulates bone developmentIEA
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One