Gene: TNFRSF13B

23495
CD267|CVID|CVID2|IGAD2|RYZN|TACI|TNFRSF14B
TNF receptor superfamily member 13B
protein-coding
17p11.2
Ensembl:ENSG00000240505 MIM:604907 Vega:OTTHUMG00000059262 UniprotKB:O14836
NG_007281.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.695e-1 (AD)  4.804e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA30.65
C5orf640.644
TRPV50.636
ARHGEF370.615
POU2AF10.615
TMEM1390.61
VRK20.606
SLCO1A20.598
SGMS20.592
MOBP0.591

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KITLG-0.426
PDZRN3-0.422
CITED2-0.413
IRS1-0.411
PIP5K1B-0.403
CUX2-0.402
ARL4C-0.4
IGSF3-0.4
HRH1-0.396
LUZP1-0.394

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of TNFRSF13B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNFRSF13B mRNA20127859|2156981
D004958EstradiolEstradiol results in increased expression of TNFRSF13B mRNA15849065
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF13B mRNA25181051
D019256Cadmium ChlorideCadmium Chloride affects the expression of TNFRSF13B mRNA18804290
D002737ChloropreneChloroprene results in decreased expression of TNFRSF13B mRNA23125180
D003703DemecolcineDemecolcine results in decreased expression of TNFRSF13B mRNA23649840
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TNFRSF13B mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TNFRSF13B mRNA23649840
D006025GlycosaminoglycansGlycosaminoglycans affects the reaction [TNFSF13B protein binds to and results in increased activity of TNFRSF13B protein]20807638
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFRSF13B mRNA25613284
C045463leflunomideleflunomide results in decreased expression of TNFRSF13B mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFRSF13B mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TNFRSF13B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TNFRSF13B mRNA"25554681
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNFRSF13B mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFRSF13B mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased expression of TNFRSF13B mRNA25549359
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNFRSF13B gene25560391
D015032ZincZinc deficiency results in increased expression of TNFRSF13B mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10801128  10880535  10956646  20676093  25416956  
GO:0038023signaling receptor activity-TAS9311921  
GO ID GO Term Qualifier Evidence PubMed
GO:0001782B cell homeostasis-IBA21873635  
GO:0002244hematopoietic progenitor cell differentiation-IBA21873635  
GO:0002250adaptive immune response-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS9311921  
GO:0030889negative regulation of B cell proliferation-IBA21873635  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04672Intestinal immune network for IgA production
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22673310Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population. (2012 Sep)Liao MGenes Immun
23303382Genome-wide association study of serum albumin:globulin ratio in Korean populations. (2013 Mar)Hong KWJ Hum Genet