Gene: RIMBP2

23504
PPP1R133|RBP2|RIM-BP2
RIMS binding protein 2
protein-coding
12q24.33
Ensembl:ENSG00000060709 MIM:611602 Vega:OTTHUMG00000168385 UniprotKB:O15034
NC_000012.12
SNP Mapped
4   ANCO-SNPs
CD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.109e-1 (AD)  1.137e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10848190chr12:130717490 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs7958924chr12:130677635 (GRCh38.p7)A>Ccocaine dependenceSNV(Single Nucleotide Variation)
rs2048779chr12:130497072 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11060883chr12:130419855 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIAA1549L0.965
MYT1L0.961
SLC12A50.96
SHANK20.959
R3HDM10.956
PAK30.956
ADARB10.955
SCN3B0.955
GABRB30.953
AAK10.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.584
REST-0.579
CSAG1-0.573
MYL3-0.571
YES1-0.568
SNHG18-0.564
RAI14-0.562
COPZ2-0.552
RNF135-0.549
CNN2-0.544

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RIMBP2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIMBP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIMBP2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RIMBP2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RIMBP2 mRNA16483693
D001151ArsenicArsenic affects the methylation of RIMBP2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of RIMBP2 mRNA26705709
D001280AtrazineAtrazine results in decreased expression of RIMBP2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of RIMBP2 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of RIMBP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RIMBP2 gene28505145
D019833GenisteinGenistein results in increased methylation of RIMBP2 gene28505145
D007657Ketone BodiesKetone Bodies results in decreased expression of RIMBP2 mRNA16807920
D007854LeadLead affects the expression of RIMBP2 mRNA28903495
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RIMBP2 mRNA28001369
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of RIMBP2 mRNA22401849
D009532NickelNickel results in decreased expression of RIMBP2 mRNA24768652|2558310
D026023PermethrinPermethrin results in increased expression of RIMBP2 mRNA19017407
D011374ProgesteroneProgesterone results in increased expression of RIMBP2 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of RIMBP2 mRNA24780913
D014212TretinoinTretinoin results in increased expression of RIMBP2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of RIMBP2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RIMBP2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIMBP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RIMBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RIMBP2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of RIMBP2 gene29154799
C025643vinclozolinvinclozolin affects the expression of RIMBP2 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of RIMBP2 mRNA22615374
D015034Zinc OxideZinc Oxide analog results in decreased expression of RIMBP2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of RIMBP2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007274neuromuscular synaptic transmission-IBA21873635  
GO:0010923negative regulation of phosphatase activity-IDA19389623  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal