Gene: SCRIB

23513
CRIB1|SCRB1|SCRIB1|Vartul
scribbled planar cell polarity protein
protein-coding
8q24.3
Ensembl:ENSG00000180900 MIM:607733 Vega:OTTHUMG00000165154 UniprotKB:Q14160
NG_030583.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.459e-1 (AD)  5.037e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHM20.835
KIF5A0.805
INPPL10.787
TCF30.785
PKN10.777
RNPEPL10.777
GNAI20.763
SORBS30.756
SLC2A4RG0.754
CASKIN20.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.625
OR4F29-0.625
COL25A1-0.307
GLRA2-0.302
AARD-0.296
CDH7-0.291
PTGFR-0.284
EGFL6-0.284
C8orf34-0.283
FSTL5-0.281

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of SCRIB mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SCRIB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SCRIB mRNA19770486
D001151ArsenicArsenic affects the methylation of SCRIB gene25304211
D001280AtrazineAtrazine results in decreased expression of SCRIB mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SCRIB promoter]19654925
D004958EstradiolEstradiol results in increased phosphorylation of SCRIB protein27026707
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SCRIB mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SCRIB mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SCRIB mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCRIB mRNA28628672
C584509C646 compoundC646 compound results in increased expression of SCRIB mRNA26191083
D002104CadmiumCadmium results in decreased expression of SCRIB mRNA24067728
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCRIB mRNA24763279
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCRIB mRNA19320972
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SCRIB mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCRIB mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of SCRIB mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SCRIB protein23301498
D000431EthanolEthanol results in decreased expression of SCRIB protein20621659
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SCRIB mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SCRIB mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCRIB mRNA24763279
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SCRIB mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCRIB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of SCRIB mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SCRIB mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SCRIB mRNA23649840
C059539midostaurinmidostaurin results in increased expression of SCRIB mRNA20980353
C568376MT19c compoundMT19c compound results in decreased expression of SCRIB mRNA21781307
D010100OxygenOxygen deficiency results in increased expression of SCRIB mRNA24205000
D010936Plant ExtractsPlant Extracts results in decreased expression of SCRIB mRNA23557933
D018038Sodium SeleniteSodium Selenite results in increased expression of SCRIB mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCRIB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCRIB mRNA15328365
D014635Valproic AcidValproic Acid results in increased methylation of SCRIB gene29154799
C025643vinclozolinvinclozolin results in decreased expression of SCRIB mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11027293  15182672  15649318  15775968  15975580  16103886  
16137684  16611247  18716323  19041750  19439659  19555689  
19615732  20622900  21132015  21525870  21701506  24550280  
28169360  
GO:0035255ionotropic glutamate receptor binding-IBA21873635  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-IMP22095531  
GO:0001921positive regulation of receptor recycling-IMP15775968  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0008283cell proliferation-IDA16965391  
GO:0016080synaptic vesicle targeting-IEA-  
GO:0016477cell migration-IMP18716323  
GO:0021747cochlear nucleus development-IEA-  
GO:0035089establishment of apical/basal cell polarity-IMP19041750  
GO:0039502suppression by virus of host type I interferon-mediated signaling pathway-IEA-  
GO:0039563suppression by virus of host STAT1 activity-IEA-  
GO:0039564suppression by virus of host STAT2 activity-IEA-  
GO:0042060wound healing-IEA-  
GO:0043065positive regulation of apoptotic process-IMP19041750  
GO:0043113receptor clustering-IBA21873635  
GO:0043615astrocyte cell migration-IEA-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IBA21873635  
GO:0045930negative regulation of mitotic cell cycle-IDA16965391  
GO:0046037GMP metabolic process-IEA-  
GO:0046710GDP metabolic process-IEA-  
GO:0048488synaptic vesicle endocytosis-IEA-  
GO:0050918positive chemotaxis-IMP18716323  
GO:0060088auditory receptor cell stereocilium organization-IEA-  
GO:0060561apoptotic process involved in morphogenesis-IMP19041750  
GO:0060603mammary gland duct morphogenesis-ISS-  
GO:0071896protein localization to adherens junction-IMP16611247  
GO:0090630activation of GTPase activity-IMP19041750  
GO:0097120receptor localization to synapse-IBA21873635  
GO:0098609cell-cell adhesion-IGI16344308  
GO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane-IBA21873635  
GO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane-IEA-  
GO:0098968neurotransmitter receptor transport postsynaptic membrane to endosome-IBA21873635  
GO:0098968neurotransmitter receptor transport postsynaptic membrane to endosome-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA15182672  28169360  
GO:0005886plasma membranecolocalizes_withIDA16611247  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-IDA15649318  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0005913cell-cell adherens junction-IDA16965391  
GO:0008328ionotropic glutamate receptor complexCOLOCALIZES_WITHIBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0016323basolateral plasma membrane-IBA21873635  
GO:0030027lamellipodium-IEA-  
GO:0030054cell junction-IBA21873635  
GO:0030054cell junction-IDA-  
GO:0031252cell leading edgecolocalizes_withIDA18716323  
GO:0034750Scrib-APC-beta-catenin complex-IDA16611247  
GO:0035748myelin sheath abaxonal region-IEA-  
GO:0042734presynaptic membranecolocalizes_withIDA15182672  
GO:0044291cell-cell contact zone-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membraneCOLOCALIZES_WITHIBA21873635  
GO:0045211postsynaptic membranecolocalizes_withIDA15182672  
GO:0070062extracellular exosome-HDA20458337  
GO:0097060synaptic membraneCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-4086400PCP/CE pathwayIEA
R-HSA-4608870Asymmetric localization of PCP proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28237967Heterozygous Vangl2(Looptail) mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. (2017 Apr 1)Poobalasingam TDis Model Mech