Gene: MTREX

23517
Dob1|KIAA0052|Mtr4|SKIV2L2|fSAP118
Mtr4 exosome RNA helicase
protein-coding
5q11.2
Ensembl:ENSG00000039123 Vega:OTTHUMG00000097019 UniprotKB:P42285
NC_000005.10
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.470e-1 (AD)  2.452e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12518892chr5:55404055 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs13154710chr5:55315905 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTREX mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of MTREX mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTREX gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of MTREX mRNA20458559
D001280AtrazineAtrazine results in increased expression of MTREX mRNA25929836
D001374AzacitidineAzacitidine results in increased expression of MTREX mRNA20823114
C044887beta-methylcholinebeta-methylcholine affects the expression of MTREX mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of MTREX mRNA25181051
C030973cupric oxidecupric oxide results in decreased expression of MTREX protein25470785
C000944dicrotophosdicrotophos results in decreased expression of MTREX mRNA28302478
D004126DimethylformamideDimethylformamide results in increased expression of MTREX mRNA22169935
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTREX mRNA18936297
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MTREX mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of MTREX mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of MTREX mRNA19167457
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MTREX mRNA22634610
C544151jinfukangjinfukang results in decreased expression of MTREX mRNA27392435
C011890kojic acidkojic acid results in decreased expression of MTREX mRNA16595896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MTREX mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTREX mRNA23649840
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MTREX protein26879310
D010936Plant ExtractsPlant Extracts results in increased expression of MTREX mRNA23557933
D011794QuercetinQuercetin results in decreased expression of MTREX mRNA21632981
C010327salinomycinsalinomycin results in decreased expression of MTREX mRNA19682730
C017947sodium arsenitesodium arsenite results in decreased expression of MTREX mRNA22714537
C012589trichostatin Atrichostatin A affects the expression of MTREX mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of MTREX mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004004ATP-dependent RNA helicase activity-IBA21873635  
GO:0005515protein binding-IPI15231747  16263084  16782053  17412707  27871484  27905398  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0000460maturation of 5.8S rRNA-IBA21873635  
GO:0000460maturation of 5.8S rRNA-IMP17412707  
GO:0006364rRNA processing-TAS-  
GO:0006401RNA catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000178exosome (RNase complex)colocalizes_withIDA11719186  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16263084  16782053  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IEA-  
GO:0031499TRAMP complex-IDA21855801  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03018RNA degradation
Reactome ID Reactome Term Evidence
R-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-72312rRNA processingTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal