Gene: FOLR3

2352
FR-G|FR-gamma|gamma-hFR
folate receptor 3
protein-coding
11q13.4
Ensembl:ENSG00000110203 MIM:602469 Vega:OTTHUMG00000167870 UniprotKB:P41439
NG_032935.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.873e-2 (AD)  3.052e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNJ150.81
TRIM100.782
DPPA40.768
CEACAM30.742
TFPI20.74
TFPI0.735
TBX210.734
SULT1C20.723
MROH50.721
NLRP120.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THY1-0.55
LRTM2-0.526
SVOP-0.52
CYP46A1-0.518
EXTL1-0.517
CDK5R2-0.516
BCL11A-0.512
C1orf53-0.509
CLEC2L-0.507
KCNC2-0.502

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalTarget
DB05168VintafolideSmall Molecule742092-03-1InvestigationalTarget
ID Drug Name Action PubMed
C100187chloropicrinchloropicrin affects the expression of FOLR3 mRNA26352163
C544151jinfukangjinfukang results in increased expression of FOLR3 mRNA27392435
C016340o,p'-DDT"o,p'-DDT results in increased expression of FOLR3 mRNA"18204070
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of FOLR3 mRNA21334430
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOLR3 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOLR3 mRNA22574217

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005542folic acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007342fusion of sperm to egg plasma membrane involved in single fertilization-IBA21873635  
GO:0015884folic acid transport-TAS8110752  
GO:0035036sperm-egg recognition-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0016020membrane-TAS8110752  
GO:0019898extrinsic component of membrane-TAS8110752  
GO:0031362anchored component of external side of plasma membrane-IBA21873635  
GO:0035580specific granule lumen-TAS-  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22363809Monocyte gene expression signature of patients with early onset coronary artery disease. (2012)Sivapalaratnam SPLoS One