Gene: CLCF1

23529
BSF-3|BSF3|CISS2|CLC|NNT-1|NNT1|NR6
cardiotrophin like cytokine factor 1
protein-coding
11q13.2
Ensembl:ENSG00000175505 MIM:607672 Vega:OTTHUMG00000167669 UniprotKB:Q9UBD9
NG_013377.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.556e-1 (AD)  5.009e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF12A0.858
FOSL10.81
MAP2K30.802
ZNF8780.801
RELB0.798
C2CD4A0.794
SPOCD10.769
SPHK10.768
SERPINE10.762
TEAD40.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.423
LHX6-0.423
LRRC38-0.404
SLC7A4-0.401
KBTBD7-0.393
PVALB-0.391
FAM19A2-0.387
CASC15-0.386
ESRRG-0.383
KIT-0.382

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CLCF1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CLCF1 mRNA]"27071940
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CLCF1 mRNA"22698814|2890350
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CLCF1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CLCF1 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of CLCF1 mRNA"21346803
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CLCF1 mRNA21298039
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CLCF1 mRNA"22863853
D001280AtrazineAtrazine results in increased expression of CLCF1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CLCF1 mRNA19770486|2222880
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of CLCF1 mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of CLCF1 mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLCF1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CLCF1 mRNA25181051
D002104CadmiumCadmium results in increased expression of CLCF1 mRNA22562489
C062876cetrorelixcetrorelix results in decreased expression of CLCF1 mRNA21062912
D002746ChlorpromazineChlorpromazine results in increased expression of CLCF1 mRNA21683644
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLCF1 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLCF1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of CLCF1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of CLCF1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CLCF1 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of CLCF1 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of CLCF1 mRNA25562108
C014347decitabinedecitabine results in increased expression of CLCF1 mRNA19194470
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLCF1 mRNA28628672
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CLCF1 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of CLCF1 mRNA26485663
D004112DimercaprolDimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]16377760
C082360fipronilfipronil results in increased expression of CLCF1 mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLCF1 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLCF1 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of CLCF1 mRNA19167457
C039281furanfuran results in increased expression of CLCF1 mRNA25539665
C004312glycidolglycidol results in increased expression of CLCF1 mRNA24915197
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CLCF1 mRNA20044591
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLCF1 mRNA28628672
D007213IndomethacinIndomethacin inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]16377760
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CLCF1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CLCF1 mRNA25307878|2675264
C045463leflunomideleflunomide results in increased expression of CLCF1 mRNA28988120
C018091maduramicinmaduramicin results in increased expression of CLCF1 mRNA29128925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CLCF1 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CLCF1 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of CLCF1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CLCF1 mRNA26011545
D009151Mustard GasDimercaprol inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]16377760
D009151Mustard GasIndomethacin inhibits the reaction [Mustard Gas results in increased expression of CLCF1 mRNA]16377760
D009151Mustard GasMustard Gas results in increased expression of CLCF1 mRNA16377760
D009532NickelNickel results in increased expression of CLCF1 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of CLCF1 mRNA22110744
C028007nickel monoxidenickel monoxide results in increased expression of CLCF1 mRNA19167457
C570897NSC668394NSC668394 results in increased expression of CLCF1 mRNA27137931
D009966OrphenadrineOrphenadrine affects the expression of CLCF1 mRNA23665939
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of CLCF1 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of CLCF1 mRNA18445702
D010936Plant ExtractsPlant Extracts results in decreased expression of CLCF1 mRNA23557933
C045950propiconazolepropiconazole results in increased expression of CLCF1 mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of CLCF1 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of CLCF1 mRNA23224687
D012834SilverSilver results in increased expression of CLCF1 mRNA26014281
D012834SilverSilver results in increased expression of CLCF1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of CLCF1 mRNA27862939
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of CLCF1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CLCF1 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of CLCF1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CLCF1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CLCF1 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CLCF1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of CLCF1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of CLCF1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CLCF1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CLCF1 mRNA26682919
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of CLCF1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI15272019  
GO:0005125cytokine activity-IBA21873635  
GO:0005125cytokine activitycontributes_toIDA10966616  
GO:0005125cytokine activity-NAS10500198  
GO:0005127ciliary neurotrophic factor receptor binding-IDA11285233  
GO:0005127ciliary neurotrophic factor receptor bindingcontributes_toIDA10966616  
GO:0005515protein binding-IPI10966616  
GO:0008083growth factor activity-TAS14632778  
GO:0046982protein heterodimerization activity-IDA10966616  
GO ID GO Term Qualifier Evidence PubMed
GO:0002639positive regulation of immunoglobulin production-ISS-  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007166cell surface receptor signaling pathway-ISS-  
GO:0007259JAK-STAT cascade-ISS-  
GO:0008284positive regulation of cell proliferation-IDA10966616  11285233  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0019221cytokine-mediated signaling pathway-NAS10500198  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030183B cell differentiation-ISS-  
GO:0030890positive regulation of B cell proliferation-IBA21873635  
GO:0030890positive regulation of B cell proliferation-ISS-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA10966616  11285233  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-TAS14632778  
GO:0043524negative regulation of neuron apoptotic process-IDA10966616  11285233  
GO:0048295positive regulation of isotype switching to IgE isotypes-ISS-  
GO:0048711positive regulation of astrocyte differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-IDA10966616  
GO:0005576extracellular region-NAS10448081  
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IEA-  
GO:0097058CRLF-CLCF1 complex-IBA21873635  
GO:0097058CRLF-CLCF1 complex-IDA10966616  
GO:0097059CNTFR-CLCF1 complex-IBA21873635  
GO:0097059CNTFR-CLCF1 complex-IDA11285233  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal