Gene: NNT

23530
GCCD4
nicotinamide nucleotide transhydrogenase
protein-coding
5p12
Ensembl:ENSG00000112992 MIM:607878 Vega:OTTHUMG00000096961 UniprotKB:Q13423
NG_032869.1
PubMed
0   ANCO-SNPs
OD|ND|AD
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.817e-1 (AD)  7.008e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMOD20.924
GFM10.921
EPS150.916
SPIN10.903
CKAP50.902
AGGF10.9
LRPPRC0.9
NDUFS10.898
CLASP20.898
ABI20.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.648
CSAG1-0.336
PRRX2-0.328
SPINK8-0.323
MTRNR2L6-0.297
MTRNR2L10-0.295
TFPI2-0.292
NANOGNB-0.292
C9orf135-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NNT mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NNT mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NNT mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of NNT mRNA29067470
D000393Air PollutantsAir Pollutants analog results in decreased expression of NNT mRNA21757418
D000638AmiodaroneAmiodarone results in increased expression of NNT mRNA17991464
C015001arsenitearsenite results in increased methylation of NNT promoter23974009
C547126AZM551248AZM551248 results in increased expression of NNT mRNA22323515
D004958EstradiolEstradiol affects the expression of NNT mRNA22574217
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of NNT mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of NNT mRNA21179406
D001663BilirubinBilirubin results in decreased expression of NNT mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of NNT mRNA29275510
C006780bisphenol Abisphenol A affects the expression of NNT mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of NNT mRNA26496021
C013418bromfenacoumbromfenacoum results in increased expression of NNT protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of NNT mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of NNT mRNA26079696
C018021cobaltous chloridecobaltous chloride results in decreased expression of NNT mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of NNT mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of NNT mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of NNT mRNA19789285
D019327Copper SulfateCopper Sulfate results in decreased expression of NNT mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of NNT mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of NNT mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NNT mRNA]27941970
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of NNT mRNA26924002
D004026DieldrinDieldrin results in decreased expression of NNT mRNA23153324
D004041Dietary FatsDietary Fats results in increased expression of NNT mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NNT mRNA21658437
C024629dimethyl phthalatedimethyl phthalate results in increased expression of NNT mRNA26924002
D004147DioxinsDioxins affects the expression of NNT mRNA20463971
D004237DiuronDiuron results in decreased expression of NNT mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NNT mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NNT mRNA16079270
C540355fenamidonefenamidone results in increased expression of NNT mRNA27029645
D005485FlutamideFlutamide results in decreased expression of NNT mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of NNT mRNA23649840
D005839GentamicinsGentamicins results in increased expression of NNT mRNA22061828
D005947GlucoseNNT protein affects the susceptibility to Glucose23504317
D005947GlucoseNNT protein results in decreased metabolism of Glucose23504317
D006533HeptachlorHeptachlor results in decreased expression of NNT mRNA23153324
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of NNT mRNA25270620
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NNT mRNA21179406
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NNT protein18951874
C492448ICG 001ICG 001 results in decreased expression of NNT mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NNT mRNA25613284
D007649KetamineKetamine results in decreased expression of NNT mRNA20080153
D008694MethamphetamineMethamphetamine results in increased expression of NNT mRNA19149911
C004925methylmercuric chloridemethylmercuric chloride affects the expression of NNT protein27012723
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of NNT protein26558463
D008917MirexMirex results in decreased expression of NNT mRNA23153324
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of NNT mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NNT mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of NNT mRNA24136188
C025256nonylphenolnonylphenol results in increased expression of NNT mRNA22982499
C025589ochratoxin Aochratoxin A results in increased expression of NNT protein26861962
D000073878Palm OilPalm Oil results in increased expression of NNT mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NNT mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NNT mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of NNT mRNA17097637
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NNT mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of NNT mRNA23811191
D011372ProgestinsProgestins results in increased expression of NNT mRNA19609016
C045950propiconazolepropiconazole results in decreased expression of NNT mRNA21278054
C513428pyrachlostrobinpyrachlostrobin results in increased expression of NNT mRNA27029645
D012822Silicon DioxideSilicon Dioxide results in decreased expression of NNT mRNA25351596
C016104sodium bichromatesodium bichromate results in decreased expression of NNT mRNA25993096
D013311StreptozocinStreptozocin results in increased expression of NNT protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of NNT protein]19634143
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NNT mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NNT mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of NNT mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NNT mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NNT mRNA16922920
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NNT mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NNT mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NNT mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of NNT protein18951874
C024746tobacco tartobacco tar results in increased expression of NNT mRNA19559774
D014118Toxins, Biological"Toxins, Biological affects the expression of NNT mRNA"19682533
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of NNT protein]19634143
C406224valdecoxibvaldecoxib results in decreased expression of NNT mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of NNT mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NNT mRNA23179753|2493525
D014640VancomycinVancomycin results in increased expression of NNT mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NNT gene25560391
D014750VincristineVincristine results in decreased expression of NNT mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of NNT mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003957NAD(P)+ transhydrogenase (B-specific) activity-TAS9524818  
GO:0008746NAD(P)+ transhydrogenase activity-EXP10673423  
GO:0008750NAD(P)+ transhydrogenase (AB-specific) activity-IBA21873635  
GO:0050661NADP binding-IBA21873635  
GO:0050661NADP binding-IDA10673423  
GO:0051287NAD binding-IBA21873635  
GO:0051287NAD binding-TAS10673423  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0006099tricarboxylic acid cycle-TAS10673423  
GO:0006740NADPH regeneration-IBA21873635  
GO:0010918positive regulation of mitochondrial membrane potential-IEA-  
GO:0032364oxygen homeostasis-IEA-  
GO:0033273response to vitamin-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-TAS10673423  
GO:0072593reactive oxygen species metabolic process-IMP22634753  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1902600proton transmembrane transport-TAS10673423  
GO:1903285positive regulation of hydrogen peroxide catabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS10673423  
GO:0005746mitochondrial respiratory chain-TAS10673423  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25214750Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment. (2013 Dec)Chen LSJ Food Drug Anal
26424102A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for prehypertensive and hypertensive patients: a quasi-experimental study in Greece. (2016 Jun)Darviri CJ Hum Hypertens
27208830Pathways to precision medicine in smoking cessation treatments. (2018 Mar 16)Chen LSNeurosci Lett
25234126Aclidinium bromide for stable chronic obstructive pulmonary disease. (2014 Sep 19)Ni HCochrane Database Syst Rev
24945054- (2014 May)Jonas DE-
15674887Opioid antagonists for alcohol dependence. (2005 Jan 25)Srisurapanont MCochrane Database Syst Rev
27943404The prevalence of ALK rearrangement in pulmonary adenocarcinomas in an unselected Caucasian population from a defined catchment area: impact of smoking. (2017 May)Skov BGHistopathology