Gene: MMD

23531
MMA|MMD1|PAQR11
monocyte to macrophage differentiation associated
protein-coding
17q22
Ensembl:ENSG00000108960 MIM:604467 Vega:OTTHUMG00000177845 UniprotKB:Q15546
NC_000017.11
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
6.317e-2 (AD)  2.697e-2 (ND)   (Frontal_Cortex)
7.250e-1 (AD)  2.972e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4630612chr17:55420404 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP2R5C0.864
CCNY0.864
CHMP30.861
ARPP190.847
SUB10.846
PLEKHB20.836
RNF110.824
MZT10.823
SLC30A90.822
EIF4E30.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.564
CSAG1-0.356
S100A12-0.311
MAGEA12-0.309
FOXJ1-0.305
EVC2-0.302
FXYD3-0.299
TGIF1-0.298
WDR38-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMD mRNA28329830
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of MMD mRNA"21920950
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MMD mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MMD mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MMD mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MMD mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MMD mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MMD mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MMD protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MMD mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MMD mRNA23630614
C006632arsenic trioxidearsenic trioxide results in increased expression of MMD mRNA20458559
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MMD mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MMD mRNA22342234
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MMD mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of MMD mRNA21185374
C006780bisphenol Abisphenol A affects the expression of MMD mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of MMD mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of MMD mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MMD mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MMD mRNA25181051
D002994ClofibrateClofibrate results in increased expression of MMD mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of MMD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MMD mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of MMD mRNA20106945
C014347decitabinedecitabine affects the expression of MMD mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MMD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MMD mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of MMD mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MMD mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MMD mRNA28962523
D002945CisplatinCisplatin affects the expression of MMD mRNA23300844
D002945CisplatinCisplatin results in increased expression of MMD mRNA27594783
D004026DieldrinDieldrin results in decreased expression of MMD mRNA28385952
D004026DieldrinDieldrin results in increased expression of MMD mRNA23153324
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MMD mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of MMD mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of MMD mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MMD mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of MMD mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of MMD mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of MMD mRNA16002434
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MMD mRNA27638505
D004237DiuronDiuron results in decreased expression of MMD mRNA25152437
D004610Ellagic AcidEllagic Acid results in increased expression of MMD mRNA12002526
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of MMD mRNA"15919760
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMD mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MMD mRNA29097150
D011345FenofibrateFenofibrate results in increased expression of MMD mRNA25572481
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMD mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of MMD mRNA23649840
C039281furanfuran results in increased expression of MMD mRNA27387713
D006533HeptachlorHeptachlor results in increased expression of MMD mRNA23153324
D017313FenretinideFenretinide results in decreased expression of MMD mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MMD mRNA18951874
C492448ICG 001ICG 001 results in increased expression of MMD mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MMD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MMD mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMD mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MMD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of MMD mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of MMD mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MMD mRNA23086925
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMD mRNA25119042
C045463leflunomideleflunomide results in increased expression of MMD mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MMD mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MMD mRNA15919760
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MMD mRNA23649840
D015735MifepristoneMifepristone results in increased expression of MMD mRNA17584828
D008917MirexMirex results in increased expression of MMD mRNA23153324
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MMD mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMD mRNA"25620056
D009966OrphenadrineOrphenadrine affects the expression of MMD mRNA23665939
D000073878Palm OilPalm Oil results in decreased expression of MMD mRNA18042831
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMD mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of MMD mRNA25119042
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of MMD mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MMD mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MMD mRNA28511854
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MMD mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of MMD mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of MMD mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MMD mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MMD mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of MMD mRNA18301758|2381119
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MMD mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MMD mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of MMD mRNA20864642
C045950propiconazolepropiconazole results in decreased expression of MMD mRNA21278054
C059514resveratrolresveratrol results in increased expression of MMD mRNA12002526
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MMD mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MMD mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MMD mRNA23221170
D013605T-2 ToxinT-2 Toxin results in decreased expression of MMD mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMD mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMD mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMD mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of MMD mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMD mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MMD gene27618143
D014635Valproic AcidValproic Acid affects the expression of MMD mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MMD mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of MMD gene29154799
D014635Valproic AcidValproic Acid affects the expression of MMD mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MMD mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MMD gene25560391
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of MMD mRNA21503142
D014750VincristineVincristine results in increased expression of MMD mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of MMD mRNA26682919
D024483Vitamin K 3MMD affects the susceptibility to Vitamin K 322715409
D024483Vitamin K 3Vitamin K 3 affects the expression of MMD mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA21968647  
GO:0038023signaling receptor activity-TAS7503749  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-IEA-  
GO:0019835cytolysis-IEA-  
GO:0032880regulation of protein localization-IDA21968647  
GO:0045666positive regulation of neuron differentiation-IDA21968647  
GO:0045860positive regulation of protein kinase activity-IDA21968647  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0005794Golgi apparatus-IDA21968647  
GO:0005887integral component of plasma membrane-TAS7503749  
GO:0016020membrane-TAS7503749  
GO:0031902late endosome membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26140494Operative wound-related complications after cranial revascularization surgeries. (2015 Nov)Takanari KJ Neurosurg
27113098CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)Wu YYJ Formos Med Assoc
27294081The Association between Muscle Mass Deficits Estimated from Bioelectrical Impedance Analysis and Lumbar Spine Bone Mineral Density in Korean Adults. (2016 May)Jang HYJ Bone Metab