Gene: PRAME

23532
CT130|MAPE|OIP-4|OIP4
preferentially expressed antigen in melanoma
protein-coding
22q11.22
Ensembl:ENSG00000185686 MIM:606021 Vega:OTTHUMG00000151172 UniprotKB:P78395
NC_000022.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.756e-1 (AD)  1.502e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTCFL0.947
HOXB90.93
PAGE50.911
HBG10.908
SSX10.906
IGF2BP10.902
MAGEC20.897
RHAG0.894
MAGEA60.884
MAGEB20.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC11A-0.221
ARSF-0.207
SHBG-0.201
SPATA2L-0.199
CRHBP-0.198
FJX1-0.196
CRH-0.191
ACY3-0.19
SST-0.186
HES6-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"[4,4'-hexafluorisopropylidene diphenol binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form]"28751236
C103303alitretinoinalitretinoin promotes the reaction [RARA protein binds to PRAME protein]16179254
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to PRAME protein]23665804
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PRAME mRNA17404688
C044887beta-methylcholinebeta-methylcholine affects the expression of PRAME mRNA21179406
C006780bisphenol A[bisphenol A binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to PRAME protein modified form]28751236
C006780bisphenol Abisphenol A results in decreased expression of PRAME mRNA25181051
D002794CholineCholine affects the expression of PRAME mRNA17616785
D017373Cyproterone Acetate[Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form]28751236
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRAME mRNA26752646
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] affects the localization of PRAME protein23460923
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PRAME mRNA23460923
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PRAME mRNA24810058
D015741Metribolone[Metribolone binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PRAME protein modified form]28751236
C119536nickel acetateNFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of PRAME mRNA]23023193
C119536nickel acetatenickel acetate results in decreased expression of PRAME mRNA23023193
D010457Peptidoglycan[Peptidoglycan co-treated with IFNG protein] affects the localization of PRAME protein23460923
D010457Peptidoglycan[Peptidoglycan co-treated with IFNG protein] results in increased expression of PRAME mRNA23460923
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PRAME mRNA17404688
D013629TamoxifenTamoxifen inhibits the reaction [ESR1 protein binds to PRAME protein]23665804
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRAME mRNA21296121
D014212TretinoinPRAME protein results in decreased activity of Tretinoin16179254
D014212TretinoinTretinoin promotes the reaction [RARA protein binds to PRAME protein]16179254
D014415TunicamycinTunicamycin results in decreased expression of PRAME mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of PRAME mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of PRAME gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16179254  
GO:0042974retinoic acid receptor binding-IDA16179254  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0008284positive regulation of cell proliferation-IDA16179254  
GO:0030154cell differentiation-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0043066negative regulation of apoptotic process-IDA16179254  
GO:0045596negative regulation of cell differentiation-IDA16179254  
GO:0045892negative regulation of transcription, DNA-templated-IDA16179254  
GO:0048387negative regulation of retinoic acid receptor signaling pathway-IDA16179254  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16475205Expression of cancer testis antigens in head and neck squamous cell carcinomas. (2006 Jul)Figueiredo DLHead Neck
27794402The prevalence of expression of MAGE-A3 and PRAME tumor antigens in East and South East Asian non-small cell lung cancer patients. (2016 Nov)Thongprasert SLung Cancer