Gene: FOSB

2354
AP-1|G0S3|GOS3|GOSB
FosB proto-oncogene, AP-1 transcription factor subunit
protein-coding
19q13.32
Ensembl:ENSG00000125740 MIM:164772 Vega:OTTHUMG00000182122 UniprotKB:P53539
NG_029675.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
21   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.477e-1 (AD)  6.500e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPAS40.834
NR4A30.814
EGR10.758
PPP1R15A0.715
EGR20.709
KDM6B0.691
EGR40.69
NFKBID0.689
NR4A10.687
JUN0.649

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFTN2-0.302
CA14-0.239
ANLN-0.238
UGT8-0.232
SPATA3-0.228
CTNNA3-0.22
CLCA4-0.219
BTBD8-0.219
GPSM2-0.216
GPR17-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FOSB mRNA"25614096
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein19464336
C0312782-chloroethyl ethyl sulfide[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein]19464336
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased activity of FOSB protein18675330
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of FOSB protein18675330
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of FOSB mRNA"19561079
C0209224-O-methyl-12-O-tetradecanoylphorbol 13-acetate4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOSB mRNA17324382
C0209224-O-methyl-12-O-tetradecanoylphorbol 13-acetate4-O-methyl-12-O-tetradecanoylphorbol 13-acetate results in increased expression of FOSB protein17324382
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]17933546
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa results in increased expression of FOSB protein]17933546|1963653
D000082AcetaminophenAcetaminophen results in increased expression of FOSB mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FOSB mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FOSB mRNA11264010
D000111Acetylcysteine[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein]19464336
D000376AgmatineAgmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]15899480
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of FOSB mRNA"23195993
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"FOSB protein results in increased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"21907220
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein]19464336
D000638AmiodaroneAmiodarone results in increased expression of FOSB mRNA19774075
D003913DextroamphetamineDextroamphetamine results in increased expression of FOSB mRNA12558987
D003913DextroamphetamineDextroamphetamine affects the expression of FOSB protein12726824
D003913DextroamphetamineDextroamphetamine deficiency affects the reaction [Dextroamphetamine affects the expression of FOSB protein]12726824
D003913DextroamphetamineDextroamphetamine results in increased expression of FOSB mRNA1347779
D003913DextroamphetamineDextroamphetamine results in increased expression of FOSB protein16678866
D003913Dextroamphetamine[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein16678866
D000661AmphetamineAmphetamine promotes the reaction [JUN protein binds to FOSB protein]15814102
D000661AmphetamineAmphetamine results in increased activity of [JUN protein binds to FOSB protein]15814102
D000661AmphetamineAmphetamine results in increased expression of FOSB protein15814102
D000661AmphetamineAmphetamine results in increased expression of FOSB mRNA19710318
D000661AmphetamineAmphetamine results in increased expression of FOSB protein alternative form12417638
D000661AmphetamineSCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]19710318
D000661AmphetamineAmphetamine promotes the reaction [FOSB protein alternative form binds to FOS promoter]18632938
D000661AmphetamineAmphetamine results in increased expression of FOSB mRNA17324382
D000661AmphetamineAmphetamine results in increased expression of FOSB protein alternative form15926929
D000661AmphetamineFOSB protein alternative form inhibits the reaction [Amphetamine results in increased expression of FOS mRNA]18632938
D000841AnisomycinAnisomycin results in increased expression of FOSB mRNA18241849
D000936Antigen-Antibody ComplexAntigen-Antibody Complex results in increased expression of FOSB mRNA25451590
D000936Antigen-Antibody Complexshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]25451590
D001151ArsenicArsenic affects the methylation of FOSB gene26411935
D001151ArsenicArsenic results in increased expression of FOSB26411935
C006632arsenic trioxidearsenic trioxide results in decreased expression of FOSB mRNA19410645
C015001arsenitearsenite affects the expression of FOSB mRNA22959463
D001194AsbestosAsbestos results in decreased expression of FOSB mRNA21563230
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of FOSB mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FOSB mRNA"18687144|2535159
D001241AspirinAspirin results in decreased expression of FOSB mRNA15928584
D001280AtrazineAtrazine results in decreased expression of FOSB mRNA25929836
D001280AtrazineAtrazine results in increased expression of FOSB mRNA27614199
C005177benserazide, levodopa drug combination"benserazide, levodopa drug combination results in increased expression of FOSB protein"18434508
C005177benserazide, levodopa drug combination"Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein]"18434508
D001554BenzeneBenzene results in decreased expression of FOSB mRNA16188089|1916216
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOSB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FOSB mRNA27195522
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FOSB mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FOSB mRNA"19150397
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of FOSB mRNA20660070
D004958EstradiolEstradiol results in increased expression of FOSB mRNA19153601
D004958EstradiolEstradiol affects the expression of FOSB mRNA15598610
D004958EstradiolEstradiol results in increased expression of FOSB mRNA25210133
C006780bisphenol Abisphenol A affects the methylation of FOSB promoter27334623
C006780bisphenol Abisphenol A results in increased expression of FOSB mRNA25270620
C006780bisphenol Abisphenol A affects the expression of FOSB mRNA21786754
C018475butyraldehydebutyraldehyde results in increased expression of FOSB mRNA26079696
C047047cabergoline"cabergoline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein]"8714707
D002104CadmiumCadmium results in decreased expression of FOSB mRNA16439709
D002104CadmiumCadmium results in increased expression of FOSB mRNA21694771
C028031cadmium acetatecadmium acetate results in increased expression of FOSB mRNA18155341
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FOSB mRNA21219922
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FOSB protein21219922
D000001CalcimycinCalcimycin results in increased expression of FOSB mRNA25451590|8764118
D000001Calcimycinshikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA]25451590
D002746ChlorpromazineChlorpromazine affects the expression of FOSB mRNA20843724
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOSB gene20938992
D002994ClofibrateClofibrate analog results in increased expression of FOSB mRNA8764118
D003024ClozapineClozapine results in increased expression of FOSB protein alternative form15579174
D003024ClozapineDRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]15579174
D003024ClozapineClozapine results in decreased expression of FOSB mRNA12093589
D003024ClozapineClozapine results in increased expression of FOSB mRNA12093589|1224376
D003024ClozapineClozapine results in increased expression of FOSB protein11259127
D003042CocaineCocaine results in increased expression of FOSB protein15814102
D003042CocaineCocaine affects the expression of FOSB mRNA18355967
D003042CocaineCocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]]20056891
D003042CocaineCocaine promotes the reaction [EHMT2 protein binds to FOSB protein]20056891
D003042CocaineCocaine results in increased expression of FOSB mRNA20056891
D003042CocaineCocaine results in increased expression of FOSB protein10103106
D003042CocaineCocaine results in increased expression of FOSB protein alternative form12417638|1671031
D003042Cocaine[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein15056714
D003042Cocaine[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein15056714
D003042CocaineEHMT2 protein inhibits the reaction [Cocaine results in increased expression of FOSB mRNA]20056891
D003042Cocaine[JUND protein results in decreased activity of FOSB protein] which results in decreased susceptibility to Cocaine20056891
D003042Cocaine"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]"16710312
D003042CocainePPP1R1B gene mutant form inhibits the reaction [Cocaine results in increased expression of FOSB protein]10103106
D003042CocaineSL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]16263220
D003042CocaineSL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]15056714
D003042CocaineSL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]15056714
D003042CocaineCocaine affects the expression of FOSB mRNA20633205
D003042CocaineCocaine affects the expression of FOSB protein20633205
D003042CocaineCocaine results in increased expression of FOSB mRNA11739600|2789988
D003042CocaineCocaine results in increased expression of FOSB protein11391778|1173960
D003042CocaineCocaine results in increased expression of FOSB protein alternative form15926929|1667492
D003042CocaineDRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]16674926
D003042CocaineDRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]16674926
D003042CocaineSCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein]16674926|1882227
D003042CocaineSCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]16674926
D003042CocaineCocaine results in increased expression of FOSB protein18355967
D005576ColforsinColforsin results in increased expression of FOSB mRNA17324382
D005576ColforsinColforsin results in increased expression of FOSB protein17324382
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of FOSB mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of FOSB mRNA22077320
C054531CY 208-243CY 208-243 results in increased expression of FOSB protein8714707
C054531CY 208-243CY 208-243 results in increased expression of FOSB mRNA8714707
C054531CY 208-243CY 208-243 results in increased expression of FOSB protein8714707
C089595cylindrospermopsincylindrospermopsin results in increased expression of FOSB mRNA23726867|2492166
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FOSB mRNA24317228
C025351delta(9)-tetrahydrocannabinolic aciddelta(9)-tetrahydrocannabinolic acid results in increased expression of FOSB protein alternative form18293355
D013759DronabinolDronabinol results in increased expression of FOSB mRNA18454173
D013759DronabinolDronabinol results in increased expression of FOSB mRNA29082320
D013759DronabinolDronabinol results in increased expression of FOSB protein alternative form29082320
D013759Dronabinol[Dronabinol results in increased susceptibility to Dronabinol] which results in decreased expression of FOSB mRNA29082320
D013759Dronabinol[Dronabinol results in increased susceptibility to Dronabinol] which results in increased expression of FOSB mRNA alternative form29082320
D013759Dronabinol[Dronabinol results in increased susceptibility to Dronabinol] which results in increased expression of FOSB protein alternative form29082320
D013759DronabinolDronabinol results in increased expression of FOSB protein9751146
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in increased expression of FOSB protein]9751146
C479072delta-tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein]19464336
C007262deoxynivalenoldeoxynivalenol affects the activity of FOSB protein10662601
D003907DexamethasoneDexamethasone results in increased expression of FOSB mRNA25047013
C020735dibutyldichlorotindibutyldichlorotin results in increased expression of FOSB mRNA10722888
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FOSB mRNA27392435
D0199003,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"FOSB protein results in increased susceptibility to 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer"21907220
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of FOSB mRNA28085963
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of FOSB mRNA23999411
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA24690739
D016291Dizocilpine MaleateFOSB protein modified form results in increased susceptibility to Dizocilpine Maleate24067299
D007980LevodopaFOSB results in increased susceptibility to Levodopa20505100
D007980Levodopa[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein15207268|1952036
D007980LevodopaLevodopa results in increased expression of FOSB protein16139809
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein16139809
D007980Levodopa6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]17933546
D007980Levodopa6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Levodopa results in increased expression of FOSB protein]17933546|1963653
D007980Levodopa[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein17933546
D007980LevodopaLevodopa promotes the reaction [Oxidopamine results in increased expression of FOSB protein]16095907
D007980LevodopaLevodopa results in increased expression of FOSB mRNA11739600|1705565
D007980LevodopaLevodopa results in increased expression of FOSB protein10600402|1173960
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein15659429
D007980Levodopa[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOSB mRNA22079256
D000431EthanolEthanol results in increased expression of FOSB protein alternative form18293355
D005473FluoxetineFluoxetine results in increased expression of FOSB mRNA18758753
D005473FluoxetineFluoxetine results in increased expression of FOSB protein18758753
D005473FluoxetineN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
D005473Fluoxetinetyrphostin AG 1478 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
D005473Fluoxetinetyrphostin AG 1478 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]18758753
D005473FluoxetineU 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
D005473FluoxetineU 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]18758753
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of FOSB mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOSB gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of FOSB mRNA17938736|2065599
D024504gamma-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide results in increased activity of and results in increased expression of FOSB protein]19464336
D006220HaloperidolHaloperidol results in increased expression of FOSB protein alternative form15579174
D006220Haloperidol8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]19695244
D006220HaloperidolHaloperidol results in increased expression of FOSB modified form24067299
D006220HaloperidolHaloperidol results in increased expression of FOSB mRNA12243769|1969524
D006220HaloperidolHaloperidol results in increased expression of FOSB protein11180499|8714707
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of FOSB mRNA20044591
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of FOSB mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of FOSB mRNA19153601
D007052IbuprofenIbuprofen results in increased expression of FOSB mRNA17070997
C051890irinotecanirinotecan metabolite results in increased expression of FOSB mRNA15956246
C051890irinotecanirinotecan results in increased expression of FOSB mRNA15956246
D007545IsoproterenolIsoproterenol results in increased expression of FOSB7905536
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FOSB mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FOSB mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOSB mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FOSB mRNA26558777
C119620kenpaullonekenpaullone results in increased expression of FOSB mRNA17993264
C031895lead chromatelead chromate results in increased expression of FOSB mRNA23584427
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]"15187114
C482199lipopolysaccharide, E coli O55-B5"Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]"15187114
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FOSB mRNA12057914
D008094LithiumLithium results in increased expression of FOSB mRNA21092101
D008148Lovastatin"Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein]"18434508
D047311LuteolinLuteolin results in decreased activity of FOSB protein16343431
D008558MelphalanMelphalan results in increased expression of FOSB mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOSB gene20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of FOSB mRNA24657277
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOSB mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FOSB mRNA"20188158
D008774MethylphenidateMethylphenidate results in increased expression of FOSB protein15916815
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein"27566062
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein alternative form"27566062
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein"8714707
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"cabergoline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of FOSB protein]"8714707
D009020MorphineMorphine results in increased expression of FOSB mRNA22454534
D009020MorphineAgmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]15899480
D009020MorphineMorphine results in increased expression of FOSB mRNA22454534
D009020MorphineMorphine results in increased expression of FOSB protein15899480|2318558
D009020MorphineMorphine results in increased expression of FOSB protein alternative form18293355
D009020MorphineMorphine results in increased expression of FOSB protein modified form23185589
C092756N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
C518313N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine results in increased expression of FOSB mRNA"19695244
C518313N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine"N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine results in increased expression of FOSB mRNA]"19695244
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide"N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine results in increased expression of FOSB mRNA]"19695244
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FOSB mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOSB mRNA"25102311
D009532NickelNickel results in increased expression of FOSB mRNA23195993|2476865
C022838nickel chloride[nickel chloride results in increased expression of GADD45A protein] which results in decreased expression of FOSB protein23536762
D009538NicotineNicotine results in increased expression of FOSB mRNA16949557
D009538NicotineNicotine results in increased expression of FOSB mRNA17456735
D009538NicotineNicotine results in increased expression of FOSB protein17324382
D009569Nitric OxideNitric Oxide results in increased activity of FOSB protein15949472
C478058N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine"N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]"16710312
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of FOSB mRNA27935865
D009638NorepinephrineNorepinephrine results in increased expression of FOSB7905536
C570896NSC305787NSC305787 results in increased expression of FOSB mRNA27137931
D016627Oxidopamine[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein15207268|1952036
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein16139809
D016627Oxidopamine6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein]17933546
D016627Oxidopamine[Levodopa co-treated with Oxidopamine] results in increased expression of FOSB protein17933546
D016627OxidopamineLevodopa promotes the reaction [Oxidopamine results in increased expression of FOSB protein]16095907
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein15659429
D016627OxidopamineOxidopamine results in increased expression of FOSB protein12127155|1609590
D016627Oxidopamine[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]15659429
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Haloperidol results in increased expression of FOSB mRNA]19695244
C507134ON 01910ON 01910 results in decreased expression of FOSB mRNA22351695
D010081OxazoloneOxazolone results in increased expression of FOSB mRNA23999411
D052638Particulate MatterParticulate Matter results in increased expression of FOSB mRNA17450221
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FOSB mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of FOSB mRNA27614199
D010622Phencyclidine[Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein16678866
D010622PhencyclidinePhencyclidine results in increased expression of FOSB protein16678866
D010656PhenylephrinePhenylephrine results in increased activity of FOSB protein15949472
D010656PhenylephrinePhenylephrine results in increased expression of FOSB7905536
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]20064835
D010862PilocarpinePilocarpine results in increased expression of FOSB protein16391389
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of FOSB mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of FOSB mRNA8764118
D010938Plant OilsPlant Oils results in increased expression of FOSB mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of FOSB mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of FOSB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FOSB mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of FOSB mRNA20660070
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FOSB mRNA27029645
D015474IsotretinoinIsotretinoin results in decreased expression of FOSB mRNA20436886
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in increased expression of FOSB protein]9751146
C534628SCH 23390SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]19710318
C534628SCH 23390SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein]16674926|1882227
C534628SCH 23390SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]16674926
C016101shikoninshikonin inhibits the reaction [Antigen-Antibody Complex results in increased expression of FOSB mRNA]25451590
C016101shikoninshikonin inhibits the reaction [Calcimycin results in increased expression of FOSB mRNA]25451590
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOSB mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of FOSB mRNA22300531|2535159
D012822Silicon DioxideSilicon Dioxide results in increased expression of FOSB mRNA19073995
D012834SilverSilver analog results in decreased expression of FOSB mRNA27180073
D012834SilverSilver results in increased expression of FOSB mRNA26014281
D012834SilverSilver results in increased expression of FOSB mRNA27131904
D012835Silver NitrateSilver Nitrate results in decreased expression of FOSB mRNA27180073
D019821Simvastatin"Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]"15187114
C424127SL 327SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]16263220
C424127SL 327SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]15056714
C424127SL 327SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]15056714
C110881S-nitro-N-acetylpenicillamineS-nitro-N-acetylpenicillamine results in increased activity of FOSB protein15949472
C009277sodium arsenatesodium arsenate results in increased expression of FOSB mRNA11353140
C017947sodium arsenitesodium arsenite results in increased activity of FOSB protein12220541
C017947sodium arsenitesodium arsenite results in increased expression of FOSB mRNA11353140|1601473
C017947sodium arsenitesodium arsenite results in increased methylation of FOSB gene24118411
C016104sodium bichromatesodium bichromate results in increased expression of FOSB mRNA27859739
D053260SootSoot results in increased expression of FOSB mRNA26551751
C061133tamibarotenetamibarotene results in increased expression of FOSB mRNA15498508
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FOSB mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOSB protein16985168
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOSB mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOSB mRNA16962184|2157046
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FOSB protein17148446
D013792ThalidomideThalidomide analog results in increased expression of FOSB mRNA20525221
D019284ThapsigarginThapsigargin results in increased expression of FOSB mRNA21694771
D013849ThimerosalThimerosal results in increased expression of FOSB mRNA16870260
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FOSB mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased phosphorylation of FOSB protein26191140
C024746tobacco tartobacco tar results in decreased expression of FOSB mRNA19559774
D014050TolueneToluene results in increased expression of FOSB mRNA16737738
D014212TretinoinTretinoin results in increased expression of FOSB mRNA15498508
C011559tributyltintributyltin results in increased expression of FOSB mRNA27614199
D014241TrichloroethyleneTrichloroethylene results in increased expression of FOSB mRNA25549359
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]18758753
C113580U 0126U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB mRNA]18758753
C113580U 0126U 0126 inhibits the reaction [Fluoxetine results in increased expression of FOSB protein]18758753
D014520UrethaneUrethane results in increased expression of FOSB mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of FOSB mRNA24383497
D002762CholecalciferolCholecalciferol results in increased expression of FOSB mRNA17170073
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FOSB mRNA18593933
D019287Zinc SulfateZinc Sulfate results in decreased expression of FOSB mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0003677DNA binding-TAS1900040  
GO:0008134transcription factor binding-TAS1900040  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-TAS1900040  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007565female pregnancy-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0032570response to progesterone-IEA-  
GO:0032870cellular response to hormone stimulus-IEA-  
GO:0043278response to morphine-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0051412response to corticosterone-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0071277cellular response to calcium ion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA22387553  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29090793Cocaine and the AP-1 Transcription Factor Complex. (1998 May)Hope BTAnn N Y Acad Sci
9294222FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. (1997 Sep 16)Hiroi NProc Natl Acad Sci U S A
17468183Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. (2007 Apr 1)Zhu HHum Mol Genet
17560044Elevations of FosB in the nucleus accumbens during forced cocaine abstinence correlate with divergent changes in reward function. (2007 Jul 13)Harris GCNeuroscience
27480020Disruption of a dopamine receptor complex amplifies the actions of cocaine. (2016 Sep)Perreault MLEur Neuropsychopharmacol
14566342Regulation of gene expression and cocaine reward by CREB and DeltaFosB. (2003 Nov)McClung CANat Neurosci
29093669Cocaine and Caffeine Effects on the Conditioned Place Preference Test: Concomitant Changes on Early Genes within the Mouse Prefrontal Cortex and Nucleus Accumbens. (2017)Muniz JAFront Behav Neurosci
15291243[Genetic basis of drug dependence and comorbid behavioral traits]. (2004 Jun)Agatsuma SNihon Shinkei Seishin Yakurigaku Zasshi
27494187Differential Expression of FosB Proteins and Potential Target Genes in Select Brain Regions of Addiction and Depression Patients. (2016)Gajewski PAPLoS One
21338584Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. (2011 Apr 18)Taqi MMBrain Res
11032893Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal. (2000 Nov)Loftis JMJ Neurochem
23665060Sexually dimorphic intracellular responses after cocaine-induced conditioned place preference expression. (2013 Jul 3)Nygard SKBrain Res
1631058Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. (1992 Jul 1)Hope BProc Natl Acad Sci U S A
28724635Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking. (2017 Sep 8)Kotla SJ Biol Chem
22049069Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine. (2011 Nov 2)Levine ASci Transl Med
22403532Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. (2012)El Rawas RFront Behav Neurosci
23447367Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats. (2013 Sep)Galeano PSynapse
21967557Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence. (2012 Mar)Li FAddict Biol
27765636Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin. (2016 Dec)Zhang LAm J Pathol
25522720Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression. (2015 Feb 26)Nygard SKNeuroscience
9668659Cocaine and the AP-1 transcription factor complex. (1998 May 30)Hope BTAnn N Y Acad Sci