Gene: DNPEP

23549
ASPEP|DAP
aspartyl aminopeptidase
protein-coding
2q35
Ensembl:ENSG00000123992 MIM:611367 Vega:OTTHUMG00000058919 UniprotKB:Q9ULA0
NC_000002.12
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.710e-1 (AD)  1.549e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TINF20.847
RPN20.84
GOLM10.839
NCBP20.838
NONO0.837
P4HB0.836
ACTG10.834
CAP10.832
ILF30.83
HNRNPD0.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.754
OR4F29-0.723
MOGAT2-0.168
NCBP2L-0.155
FOXB2-0.14
MTRNR2L6-0.138
TRPV5-0.13
PRDM14-0.126
MTRNR2L9-0.124
CTNNA3-0.123

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of DNPEP protein26194647
D001280AtrazineAtrazine results in increased expression of DNPEP mRNA22378314
D001663BilirubinBilirubin results in decreased expression of DNPEP mRNA20196124
C006780bisphenol Abisphenol A affects the expression of DNPEP mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DNPEP mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DNPEP mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DNPEP protein24527689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DNPEP gene20938992
D002994ClofibrateClofibrate results in decreased expression of DNPEP mRNA23811191
C018021cobaltous chloridecobaltous chloride results in increased expression of DNPEP mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of DNPEP mRNA20106945
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNPEP mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DNPEP gene20938992
C039281furanfuran results in increased expression of DNPEP mRNA26194646
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of DNPEP protein]20884965
D019833GenisteinGenistein results in decreased expression of DNPEP protein20884965
D005839GentamicinsGentamicins results in increased expression of DNPEP mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased secretion of DNPEP mRNA21179422
C492448ICG 001ICG 001 results in increased expression of DNPEP mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DNPEP mRNA25613284
D007854LeadLead results in decreased expression of DNPEP mRNA19921347
C008261lead acetatelead acetate results in decreased expression of DNPEP mRNA22609695|2527062
C008261lead acetatelead acetate results in increased expression of DNPEP mRNA21829687
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DNPEP gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DNPEP mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DNPEP mRNA23103053
D008770MethylnitrosoureaMethylnitrosourea results in decreased activity of DNPEP protein16537183
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DNPEP mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of DNPEP mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DNPEP mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNPEP mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNPEP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DNPEP mRNA22079256
D012643SeleniumSelenium results in increased expression of DNPEP mRNA19244175
C017947sodium arsenitesodium arsenite affects the expression of DNPEP mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of DNPEP mRNA16014739
D012969Sodium FluorideSodium Fluoride results in increased expression of DNPEP protein28918527
D018038Sodium SeleniteSodium Selenite results in increased expression of DNPEP mRNA18175754
D012999SomanSoman results in decreased expression of DNPEP mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DNPEP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DNPEP mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DNPEP mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DNPEP mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of DNPEP mRNA27760801
D014520UrethaneUrethane results in decreased expression of DNPEP mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DNPEP mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004177aminopeptidase activity-TAS9632644  
GO:0005515protein binding-IPI25416956  27107014  
GO:0008270zinc ion binding-IEA-  
GO:0042802identical protein binding-IPI25416956  
GO:0070006metalloaminopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006518peptide metabolic process-TAS9632644  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-IDA-  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal