Gene: FOSL2

2355
FRA2
FOS like 2, AP-1 transcription factor subunit
protein-coding
2p23.2
Ensembl:ENSG00000075426 MIM:601575 Vega:OTTHUMG00000097832 UniprotKB:P15408
NC_000002.12
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.324e-1 (AD)  4.915e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PIM10.805
CSRNP10.78
KLF60.763
NEDD90.762
MYH90.759
PIK3R30.756
SHC10.753
NFKBIZ0.751
SBNO20.748
NUP980.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.375
OR4F5-0.373
NKX2-8-0.266
HES5-0.26
RERGL-0.25
SNX22-0.25
HOXD1-0.245
TSPAN8-0.24
DIAPH3-0.24
CA14-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FOSL2 mRNA"28903501
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of FOSL2 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of FOSL2 mRNA"25614096
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein19464336
C0312782-chloroethyl ethyl sulfide[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein]19464336
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of FOSL2 protein18675330
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FOSL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FOSL2 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in decreased expression of FOSL2 mRNA"28073004
D000082AcetaminophenAcetaminophen affects the expression of FOSL2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of FOSL2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FOSL2 mRNA17562736
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOSL2 mRNA]18700144
D000111Acetylcysteine[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein]19464336
D020106AcrylamideAcrylamide results in increased expression of FOSL2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FOSL2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FOSL2 mRNA21641981|2210060
D024502alpha-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein]19464336
D000638AmiodaroneAmiodarone affects the expression of FOSL2 mRNA25064622
D003913DextroamphetamineDextroamphetamine results in increased expression of FOSL2 mRNA12205029
D003913DextroamphetamineSOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FOSL2 mRNA]12205029
D000661AmphetamineAmphetamine promotes the reaction [JUND protein binds to FOSL2 protein]15814102
D000661AmphetamineAmphetamine results in decreased expression of FOSL2 protein15814102
D000661AmphetamineAmphetamine results in increased activity of [JUND protein binds to FOSL2 protein]15814102
D000728AndrogensAndrogens results in increased expression of FOSL2 mRNA15486991
D000728AndrogensAndrogens results in increased expression of FOSL2 protein15486991
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FOSL2 mRNA24449571
C015001arsenitearsenite affects the expression of FOSL2 mRNA22959463
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FOSL2 mRNA"18687144
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FOSL2 protein"16966607
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FOSL2 protein"16966607
D001241AspirinAspirin results in increased expression of FOSL2 mRNA12800193
D001280AtrazineAtrazine results in increased expression of FOSL2 mRNA22378314
D001554BenzeneBenzene results in increased expression of FOSL2 mRNA12928149
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of FOSL2 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOSL2 mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FOSL2 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOSL2 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of FOSL2 mRNA25210133
C006780bisphenol Abisphenol A affects the expression of FOSL2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of FOSL2 promoter27334623
C006780bisphenol Abisphenol A affects the expression of FOSL2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOSL2 mRNA28628672
D020148Butyric AcidButyric Acid results in increased expression of FOSL2 mRNA12800193
D002104CadmiumCadmium results in increased expression of FOSL2 mRNA24376830
C028031cadmium acetatecadmium acetate affects the expression of FOSL2 mRNA16249259
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FOSL2 mRNA21219922|2559613
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FOSL2 protein21219922
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of FOSL2 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of FOSL2 mRNA25064622
D002746ChlorpromazineChlorpromazine affects the expression of FOSL2 mRNA20843724
D004390ChlorpyrifosChlorpyrifos results in increased expression of FOSL2 mRNA21356183
C418118CI 1044CI 1044 results in increased expression of FOSL2 mRNA17569694
C059262cidofovircidofovir results in decreased expression of FOSL2 mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of FOSL2 mRNA25596134
D003024ClozapineClozapine results in increased expression of FOSL2 mRNA12093589|1224376
C018021cobaltous chloridecobaltous chloride results in increased expression of FOSL2 mRNA24386269
D003042CocaineCocaine promotes the reaction [JUN protein binds to FOSL2 protein]15814102
D003042CocaineCocaine results in decreased expression of FOSL2 protein15814102
D003042Cocaine[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein15056714
D003042Cocaine[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein15056714
D003042CocaineSL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]15056714
D003042CocaineSL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]15056714
D003042CocaineCocaine results in increased expression of FOSL2 protein18355967
D019327Copper SulfateCopper Sulfate results in increased expression of FOSL2 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]17148446
D003474CurcuminCurcumin results in decreased expression of FOSL2 mRNA17999991
D016572CyclosporineCyclosporine affects the expression of FOSL2 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of FOSL2 mRNA25562108
C014347decitabinedecitabine results in increased expression of FOSL2 mRNA17908484
D013759DronabinolDronabinol results in increased expression of FOSL2 mRNA18454173
D013759DronabinolDronabinol results in increased expression of FOSL2 protein9751146
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL2 protein]9751146
C479072delta-tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein]19464336
C007262deoxynivalenoldeoxynivalenol affects the activity of FOSL2 protein10662601
C007262deoxynivalenoldeoxynivalenol results in increased expression of FOSL2 mRNA15371230|1568116
C007262deoxynivalenol"Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of FOSL2 mRNA]"15681167
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOSL2 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of FOSL2 mRNA17998272
C016366dibenzothiophenedibenzothiophene results in increased expression of FOSL2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FOSL2 mRNA17361019|2126653
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of FOSL2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of FOSL2 mRNA25596134
D002945CisplatinCisplatin results in increased expression of FOSL2 mRNA27594783
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of FOSL2 mRNA]27392435
D004008DiclofenacDiclofenac results in increased expression of FOSL2 mRNA26934552
D002117CalcitriolCalcitriol results in increased expression of FOSL2 mRNA16002434|2648566
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of FOSL2 mRNA17374397
D000431EthanolEthanol results in decreased expression of FOSL2 mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOSL2 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FOSL2 mRNA16079270
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FOSL2 mRNA23649840
D005054EugenolEugenol results in increased expression of FOSL2 mRNA17374397
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of FOSL2 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of FOSL2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of FOSL2 mRNA19167457
D024504gamma-Tocopherol[alpha-Tocopherol co-treated with delta-tocopherol co-treated with gamma-Tocopherol co-treated with Acetylcysteine] inhibits the reaction [2-chloroethyl ethyl sulfide affects the activity of and results in increased expression of FOSL2 protein]19464336
C056507gemcitabinegemcitabine results in decreased expression of FOSL2 mRNA17039268
D005947GlucoseGlucose results in increased expression of FOSL2 mRNA17178593
C004312glycidolglycidol results in decreased expression of FOSL2 mRNA24915197
C010974glyphosateglyphosate results in increased expression of FOSL2 mRNA25636363
D006220HaloperidolHaloperidol results in increased expression of FOSL2 mRNA12243769
D017313FenretinideFenretinide results in decreased expression of FOSL2 mRNA28973697
D006851Hydrochloric AcidHydrochloric Acid results in decreased expression of FOSL2 mRNA15046208
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FOSL2 mRNA26846883
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOSL2 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of FOSL2 mRNA28201806
D007213IndomethacinIndomethacin results in decreased expression of FOSL2 mRNA25972201
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FOSL2 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of FOSL2 mRNA21177286
D007545IsoproterenolIsoproterenol results in increased expression of FOSL2 protein21177286
D007545Isoproterenol[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]21177286
D007545IsoproterenolU 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]21177286
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of FOSL2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of FOSL2 mRNA]27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to FOSL2 gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [POLR2A protein modified form binds to FOSL2 gene]23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FOSL2 mRNA23086925
D007608Kainic AcidKainic Acid results in increased expression of FOSL2 mRNA19700661
D007854LeadLead affects the expression of FOSL2 mRNA28903495
C045463leflunomideleflunomide results in increased expression of FOSL2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]"15187114
C482199lipopolysaccharide, E coli O55-B5"Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]"15187114
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FOSL2 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA]16415329
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of FOSL2 mRNA21641980
C042720mercuric bromidemercuric bromide results in increased expression of FOSL2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
D008713MethimazoleMethimazole results in decreased expression of FOSL2 mRNA17403546
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOSL2 mRNA17961207
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FOSL2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FOSL2 mRNA23649840
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]21177286
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FOSL2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FOSL2 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of FOSL2 mRNA19812364
D009532NickelNickel results in increased expression of FOSL2 mRNA24768652|2558310
C119536nickel acetateNFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of FOSL2 mRNA]23023193
C119536nickel acetatenickel acetate results in increased expression of FOSL2 mRNA23023193
C022838nickel chloridenickel chloride results in increased expression of FOSL2 mRNA17312168
C028007nickel monoxidenickel monoxide results in decreased expression of FOSL2 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of FOSL2 mRNA16780908
C029938nickel sulfatenickel sulfate results in increased expression of FOSL2 mRNA16780908|1737439
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 inhibits the reaction [deoxynivalenol results in increased expression of FOSL2 mRNA]"15681167
D010100OxygenOxygen deficiency results in increased expression of FOSL2 mRNA25596134
C016030pantogabpantogab results in increased expression of FOSL2 mRNA17379144
D010269ParaquatParaquat affects the expression of FOSL2 mRNA25064622
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FOSL2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of FOSL2 mRNA19095052
D010634PhenobarbitalPhenobarbital results in decreased expression of FOSL2 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOSL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FOSL2 mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of FOSL2 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of FOSL2 mRNA23012394
D015237DinoprostDinoprost results in increased expression of FOSL2 mRNA11517196
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA]15477007
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA19059307
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA]16415329
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in increased expression of FOSL2 protein]9751146
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FOSL2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of FOSL2 mRNA23221170
D012834SilverSilver results in increased expression of FOSL2 mRNA26014281
D012834SilverSilver affects the expression of FOSL2 mRNA27131904
D019821Simvastatin"Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]"15187114
C424127SL 327SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]15056714
C424127SL 327SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]15056714
C009277sodium arsenatesodium arsenate results in increased expression of FOSL2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of FOSL2 mRNA11353140
C016104sodium bichromatesodium bichromate results in increased expression of FOSL2 mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of FOSL2 mRNA22110744
D012999SomanSoman results in increased expression of FOSL2 mRNA19281266
D053260SootSoot results in increased expression of FOSL2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of FOSL2 mRNA21641980
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOSL2 protein16985168
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FOSL2 mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FOSL2 mRNA24058054|2468072
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of FOSL2 mRNA28973375
D013752TetracyclineTetracycline affects the expression of FOSL2 mRNA25064622
D013755Tetradecanoylphorbol AcetateCurcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOSL2 protein]17148446
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA15477007
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FOSL2 protein17148446
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FOSL2 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOSL2 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of FOSL2 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FOSL2 mRNA28111298
C483909torcetrapibtorcetrapib results in increased expression of FOSL2 mRNA23228038
D014212TretinoinTretinoin results in increased expression of FOSL2 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FOSL2 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FOSL2 mRNA"26179874
C113580U 0126[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]21177286
C113580U 0126U 0126 inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA]21177286
D014520UrethaneUrethane results in increased expression of FOSL2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FOSL2 mRNA25064622
D014635Valproic AcidValproic Acid results in decreased expression of FOSL2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of FOSL2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of FOSL2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of FOSL2 mRNA17292431
D014640VancomycinVancomycin results in decreased expression of FOSL2 mRNA18930951
D014750VincristineVincristine results in increased expression of FOSL2 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of FOSL2 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FOSL2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FOSL2 mRNA26272509
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FOSL2 mRNA18593933
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of FOSL2 mRNA16979875
D015032ZincZinc deficiency results in decreased expression of FOSL2 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA13679379  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA13679379  
GO:0003682chromatin binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS8954781  
GO:0005515protein binding-IPI19321746  20102225  25416956  25609649  26496610  27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0003334keratinocyte development-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS8954781  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0008219cell death-TAS8954781  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA13679379  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS8954781  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26384852Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)Levran OCNS Neurosci Ther