Gene: PSD4

23550
EFA6B|TIC
pleckstrin and Sec7 domain containing 4
protein-coding
2q14.1
Ensembl:ENSG00000125637 MIM:614442 Vega:OTTHUMG00000153339 UniprotKB:Q8NDX1
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.897e-1 (AD)  9.907e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6753019chr2:113190582 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMCO40.733
ARHGEF400.733
TRIOBP0.71
INPPL10.695
RREB10.694
PLD20.69
LOXL30.69
FCGRT0.684
HFE0.684
CGNL10.681

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBLN1-0.344
MIP-0.324
GALNT14-0.322
RHO-0.319
OR4F5-0.314
ADRA1D-0.311
PCSK1-0.31
CRH-0.31
NMU-0.295
KCNB2-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PSD4 mRNA"22698814
D000082AcetaminophenAcetaminophen results in decreased expression of PSD4 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in increased expression of PSD4 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PSD4 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSD4 mRNA22316170
C006780bisphenol Abisphenol A affects the expression of PSD4 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSD4 mRNA20938992
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of PSD4 mRNA16197558
D016572CyclosporineCyclosporine results in decreased expression of PSD4 mRNA20106945
D004041Dietary FatsDietary Fats results in increased expression of PSD4 mRNA25016146
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to PSD4 protein27129696
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSD4 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of PSD4 mRNA22061828
C544151jinfukangjinfukang results in increased expression of PSD4 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PSD4 mRNA23086925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSD4 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PSD4 mRNA"25554681
D009532NickelNickel results in increased expression of PSD4 mRNA25583101
D010634PhenobarbitalPhenobarbital affects the expression of PSD4 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PSD4 mRNA19710929
D011374ProgesteroneProgesterone results in increased expression of PSD4 mRNA23012394
C005556propionaldehydepropionaldehyde results in decreased expression of PSD4 mRNA26079696
D011794QuercetinQuercetin results in increased expression of PSD4 mRNA21632981
C012526quercitrinquercitrin results in increased expression of PSD4 mRNA25193878
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PSD4 mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of PSD4 gene28589171
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PSD4 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of PSD4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PSD4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005086ARF guanyl-nucleotide exchange factor activity-IEA-  
GO:0005543phospholipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032012regulation of ARF protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0032154cleavage furrowNOTIDA23603394  
GO:0032587ruffle membrane-IBA21873635  
GO:0032587ruffle membrane-IDA23603394  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal