Gene: FPGS

2356
-
folylpolyglutamate synthase
protein-coding
9q34.11
Ensembl:ENSG00000136877 MIM:136510 Vega:OTTHUMG00000020716 UniprotKB:Q05932
NG_023245.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.561e-1 (AD)  8.457e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIRBP0.874
SGSH0.868
APH1A0.843
RNF310.839
SLC35C20.832
RPS6KB20.821
ERMARD0.812
COMMD40.811
CDPF10.81
CYB5R10.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.602
OR4F29-0.573
RAX2-0.358
MIA-0.347
EPPIN-0.323
CELSR1-0.292
KLRG1-0.271
CYP39A1-0.267
GYS2-0.256
SLFNL1-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of FPGS mRNA"28903501
C0118647-hydroxymethotrexate7-hydroxymethotrexate results in decreased activity of FPGS protein19426680
D000082AcetaminophenAcetaminophen results in decreased expression of FPGS mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of FPGS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FPGS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FPGS mRNA22209252
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FPGS mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FPGS mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of FPGS mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of FPGS mRNA25181051
D002087ButyratesButyrates results in increased expression of FPGS mRNA20072153
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FPGS mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FPGS gene20938992
D002994ClofibrateClofibrate results in decreased expression of FPGS mRNA17585979
C060728cobalt oxidecobalt oxide analog results in increased expression of FPGS mRNA24821434
C014347decitabinedecitabine results in increased expression of FPGS mRNA11509559
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FPGS mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPGS mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FPGS mRNA17108234
D005472FluorouracilFPGS protein results in increased susceptibility to Fluorouracil15542523
D005492Folic AcidFolic Acid affects the expression of FPGS mRNA17311948
D005492Folic AcidFolic Acid deficiency results in increased expression of FPGS mRNA18623116
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FPGS gene20938992
C056933fumonisin B1fumonisin B1 results in decreased expression of FPGS mRNA16221962
D005897GlafenineGlafenine results in increased expression of FPGS mRNA24136188
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of FPGS mRNA22634610
C045463leflunomideleflunomide results in increased expression of FPGS mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FPGS mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FPGS gene20938992
D008727MethotrexateFPGS protein results in increased metabolism of Methotrexate20072153
D008727MethotrexateFPGS protein results in increased metabolism of Methotrexate25013492
D008777MethyltestosteroneMethyltestosterone results in decreased expression of FPGS mRNA29191790
C568376MT19c compoundMT19c compound results in decreased expression of FPGS mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FPGS mRNA"25620056
C012655nimesulidenimesulide results in increased expression of FPGS mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FPGS mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of FPGS mRNA25729387
D000068437PemetrexedFPGS protein results in increased susceptibility to Pemetrexed17575230
C006253pirinixic acidpirinixic acid results in increased expression of FPGS mRNA15302862|1830175
D010936Plant ExtractsPlant Extracts results in decreased expression of FPGS mRNA24677778
C045950propiconazolepropiconazole results in decreased expression of FPGS mRNA21278054
D012715Sesame OilSesame Oil results in increased expression of FPGS mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of FPGS mRNA23922661
D014284TriiodothyronineTriiodothyronine results in increased expression of FPGS mRNA15953391
D013629TamoxifenTamoxifen affects the expression of FPGS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FPGS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPGS mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of FPGS mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FPGS mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FPGS mRNA15328365
D013853ThioacetamideThioacetamide results in decreased expression of FPGS mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FPGS mRNA25729387
D019772TopotecanTopotecan results in increased expression of FPGS mRNA25729387
D014520UrethaneUrethane results in decreased expression of FPGS mRNA28818685
C029297vinylidene chloridevinylidene chloride results in decreased expression of FPGS mRNA26682919
D002762CholecalciferolCholecalciferol results in decreased expression of FPGS mRNA16508948
C111237vorinostatvorinostat results in increased expression of FPGS mRNA20072153
D014859WarfarinFPGS gene polymorphism affects the susceptibility to Warfarin25079360

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004326tetrahydrofolylpolyglutamate synthase activity-IBA21873635  
GO:0004326tetrahydrofolylpolyglutamate synthase activity-IDA3619447  
GO:0004326tetrahydrofolylpolyglutamate synthase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0008841dihydrofolate synthase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006139nucleobase-containing compound metabolic process-TAS7721888  
GO:0006536glutamate metabolic process-IDA3619447  
GO:0006730one-carbon metabolic process-IEA-  
GO:0006760folic acid-containing compound metabolic process-IDA3619447  
GO:0007420brain development-IEA-  
GO:0031100animal organ regeneration-IEA-  
GO:0046655folic acid metabolic process-TAS-  
GO:0046901tetrahydrofolylpolyglutamate biosynthetic process-IDA3619447  
GO:0046901tetrahydrofolylpolyglutamate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS1409616  
GO:0005739mitochondrion-TAS7721888  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22147198Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. (2012 Apr)Wani NAMol Cell Biochem
21597034The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. (2011 Jun)Ye XPsychosom Med