Gene: DDAH2

23564
DDAH|DDAHII|G6a|HEL-S-277|NG30
dimethylarginine dimethylaminohydrolase 2
protein-coding
6p21.33
Ensembl:ENSG00000213722 MIM:604744 Vega:OTTHUMG00000031212 UniprotKB:O95865
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
4.607e-1 (AD)  2.445e-1 (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26978172chr6:31696223DDAH2Gene body3.350e-4Alcohol use disorders26763658
cg23348155chr6:31696319DDAH2Gene body7.209e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOC0.908
TRIP60.898
SZRD10.895
EFEMP20.89
GNG50.877
SORBS30.875
ATP6V0E10.871
FCGRT0.869
NECAP20.865
DBI0.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYRP1-0.546
ZNF860-0.517
GABRG3-0.513
IL12RB2-0.513
KCNS2-0.506
KCNH1-0.505
OR14I1-0.5
MCHR2-0.499
OR4F5-0.496
CALHM1-0.496

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00155L-CitrullineSmall Molecule372-75-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DDAH2 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DDAH2 mRNA"19167446
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DDAH2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DDAH2 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DDAH2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDAH2 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDAH2 mRNA22228805
D004958EstradiolEstradiol affects the expression of DDAH2 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of DDAH2 mRNA23373633
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of DDAH2 mRNA17404688
C006780bisphenol Abisphenol A affects the expression of DDAH2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DDAH2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of DDAH2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DDAH2 protein24419708
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DDAH2 protein24527689
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in decreased expression of DDAH2 mRNA18078969
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDAH2 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDAH2 mRNA19156866
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDAH2 protein19156866
C018021cobaltous chlorideDDAH2 protein promotes the reaction [Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]]19156866
C018021cobaltous chlorideTretinoin inhibits the reaction [cobaltous chloride results in decreased expression of DDAH2 mRNA]19156866
C018021cobaltous chlorideTretinoin inhibits the reaction [cobaltous chloride results in decreased expression of DDAH2 protein]19156866
D019327Copper SulfateCopper Sulfate results in decreased expression of DDAH2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of DDAH2 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of DDAH2 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of DDAH2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DDAH2 mRNA27989131
D003609DactinomycinDactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA]17977009
C016366dibenzothiophenedibenzothiophene results in decreased expression of DDAH2 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DDAH2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DDAH2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DDAH2 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of DDAH2 mRNA18042831
D004237DiuronDiuron results in decreased expression of DDAH2 mRNA25152437
C118739entinostatentinostat results in decreased expression of DDAH2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of DDAH2 promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DDAH2 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DDAH2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DDAH2 mRNA26865667
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DDAH2 mRNA17557909
D005472FluorouracilDDAH2 protein affects the susceptibility to Fluorouracil16217747
D005557FormaldehydeFormaldehyde results in decreased expression of DDAH2 mRNA24140967
D005557FormaldehydeFormaldehyde results in decreased expression of DDAH2 protein24140967
C039281furanfuran results in increased expression of DDAH2 mRNA27387713
D019833GenisteinGenistein affects the expression of DDAH2 mRNA26865667
D006493HeparinHeparin results in decreased expression of DDAH2 protein17488504
D017313FenretinideFenretinide results in increased expression of DDAH2 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of DDAH2 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of DDAH2 mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DDAH2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DDAH2 mRNA23086925
C029891lead chloridelead chloride results in increased expression of DDAH2 protein24419708
D008012LidocaineLidocaine results in decreased expression of DDAH2 protein27018092
D008012LidocaineLidocaine results in increased expression of DDAH2 mRNA27018092
D009020MorphineMorphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]23056601
D009020MorphineMorphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]23056601
D009020MorphineMorphine results in increased expression of DDAH2 protein23056601
C523799MRK 003DDAH2 results in decreased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of DDAH2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDAH2 mRNA"25554681
D000068577NebivololDactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA]17977009
D000068577NebivololNebivolol results in increased activity of DDAH2 protein17977009
D000068577NebivololNebivolol results in increased expression of DDAH2 mRNA17977009
D000068577NebivololNebivolol results in increased expression of DDAH2 protein17977009
C029938nickel sulfatenickel sulfate results in increased expression of DDAH2 mRNA22714537
D010100OxygenOxygen deficiency results in decreased expression of DDAH2 protein27313889
D010100OxygenOxygen deficiency results in increased expression of DDAH2 mRNA27313889
D000073878Palm OilPalm Oil results in increased expression of DDAH2 mRNA18042831
D010269ParaquatParaquat results in increased expression of DDAH2 mRNA20388547
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of DDAH2 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of DDAH2 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of DDAH2 mRNA19167446
D012643SeleniumSelenium results in increased expression of DDAH2 mRNA19244175
C080703SK&F 83959SK&F 83959 results in decreased expression of DDAH2 protein25852303
C017947sodium arsenitesodium arsenite results in increased expression of DDAH2 mRNA22714537
D012999SomanSoman results in increased expression of DDAH2 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of DDAH2 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of DDAH2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDAH2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDAH2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDAH2 mRNA22298810
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of DDAH2 protein"25852303
D014050TolueneToluene results in decreased expression of DDAH2 mRNA22967744
D014212TretinoinTretinoin results in decreased expression of DDAH2 mRNA17218384
D014212TretinoinDDAH2 protein promotes the reaction [Tretinoin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]]19156866
D014212TretinoinTretinoin inhibits the reaction [cobaltous chloride results in decreased expression of DDAH2 mRNA]19156866
D014212TretinoinTretinoin inhibits the reaction [cobaltous chloride results in decreased expression of DDAH2 protein]19156866
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DDAH2 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DDAH2 mRNA16141432
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in decreased expression of DDAH2 mRNA18078969
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DDAH2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DDAH2 mRNA23179753|2627250
D014640VancomycinVancomycin results in decreased expression of DDAH2 mRNA18930951
D014810Vitamin EVitamin E results in increased expression of DDAH2 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of DDAH2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS10493931  
GO:0005515protein binding-IPI16189514  19060904  
GO:0016403dimethylargininase activity-IBA21873635  
GO:0016403dimethylargininase activity-IDA10493931  
GO:0016403dimethylargininase activity-TAS-  
GO:0016597amino acid binding-IBA21873635  
GO:0016597amino acid binding-IEA-  
GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000052citrulline metabolic process-IBA21873635  
GO:0000052citrulline metabolic process-IDA10493931  
GO:0006525arginine metabolic process-IBA21873635  
GO:0006527arginine catabolic process-IEA-  
GO:0006809nitric oxide biosynthetic process-TAS10493931  
GO:0007263nitric oxide mediated signal transduction-TAS10493931  
GO:0043066negative regulation of apoptotic process-TAS16130169  
GO:0045429positive regulation of nitric oxide biosynthetic process-IBA21873635  
GO:0045429positive regulation of nitric oxide biosynthetic process-ISS-  
GO:0050999regulation of nitric-oxide synthase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-202131Metabolism of nitric oxideTAS
R-HSA-203615eNOS activationTAS
R-HSA-203765eNOS activation and regulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22923027Association study of dimethylarginine dimethylaminohydrolase 2 gene polymorphisms and coronary heart disease. (2012 Nov)Xu AGMol Med Rep