Gene info: ID 2357

Gene: FPR1

GENE ID: 2357

Synonyms: FMLP|FPR

Description: formyl peptide receptor 1

Gene type: protein-coding

Location: 19q13.41

dbXrefs: Ensembl:ENSG00000171051 MIM:136537 Vega:OTTHUMG00000183500 UniprotKB:P21462

RefSeq: NG_023426.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.023e-1 (AD) 4.826e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FCGR2A	0.95
HCK	0.933
FCGR1A	0.919
SLC11A1	0.919
TLR2	0.917
TNFRSF1B	0.913
CD14	0.909
SERPINA1	0.909
RUNX1	0.907
CD300A	0.907

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNIP3	-0.524
NEUROD6	-0.511
MARCH4	-0.501
TMEM179	-0.49
WNT7A	-0.484
DLK2	-0.483
CPLX3	-0.478
MAGIX	-0.477
RTN4R	-0.475
SPRN	-0.464

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00716	Nedocromil	Small Molecule	69049-73-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in decreased expression of FPR1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of FPR1 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of FPR1 mRNA	28959563
D000393	Air Pollutants	Air Pollutants results in decreased expression of FPR1 mRNA	23649983
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of FPR1 mRNA"	23195993
D000447	Aldehydes	Aldehydes results in increased expression of FPR1 mRNA	25014914
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of FPR1 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of FPR1 mRNA	19654921
D001241	Aspirin	Aspirin results in decreased expression of FPR1 mRNA	15928584
D001280	Atrazine	Atrazine results in increased expression of FPR1 mRNA	25929836
D001554	Benzene	Benzene results in increased expression of FPR1 mRNA	20036648
C006780	bisphenol A	bisphenol A results in increased methylation of FPR1 gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of FPR1 mRNA	26079696
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of FPR1 protein	17610505
C018021	cobaltous chloride	cobaltous chloride results in increased expression of FPR1 mRNA	23052192
D003471	Cuprizone	Cuprizone results in decreased expression of FPR1 mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in increased expression of FPR1 mRNA	20106945
C014347	decitabine	decitabine promotes the reaction [TP53 protein binds to FPR1 promoter]	19037090
C014347	decitabine	decitabine results in decreased expression of FPR1 mRNA	19037090
C014347	decitabine	decitabine results in decreased expression of FPR1 protein	19037090
D013759	Dronabinol	Dronabinol results in increased expression of FPR1 mRNA	18163980
D003907	Dexamethasone	Dexamethasone inhibits the reaction [TP53 protein binds to FPR1 promoter]	19037090
D003907	Dexamethasone	Dexamethasone results in increased expression of FPR1 mRNA	19037090\|2504701
D004041	Dietary Fats	Dietary Fats results in decreased expression of FPR1 mRNA	25016146
D002117	Calcitriol	Calcitriol results in decreased expression of FPR1 mRNA	26485663
D002117	Calcitriol	Calcitriol results in increased expression of FPR1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of FPR1 mRNA	21592394
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPR1 mRNA	17942748
D009240	N-Formylmethionine Leucyl-Phenylalanine	N-Formylmethionine Leucyl-Phenylalanine binds to and results in increased activity of FPR1 protein	17520823
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of FPR1 protein	19167369
D007975	Leukotriene B4	FPR1 protein results in increased abundance of Leukotriene B4	10477617
D007975	Leukotriene B4	MK 0591 inhibits the reaction [FPR1 protein results in increased abundance of Leukotriene B4]	10477617
D017313	Fenretinide	Fenretinide results in decreased expression of FPR1 mRNA	28973697
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FPR1 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of FPR1 mRNA	23086925
D009637	Masoprocol	Masoprocol results in decreased activity of FPR1 protein	17520823
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of FPR1 mRNA	20843944
D008727	Methotrexate	Methotrexate results in decreased expression of FPR1 mRNA	17400583\|2444957
C078266	MK 0591	MK 0591 inhibits the reaction [FPR1 protein results in increased abundance of Leukotriene B4]	10477617
C078266	MK 0591	MK 0591 results in decreased susceptibility to FPR1 protein	10477617
C523799	MRK 003	FPR1 results in increased susceptibility to MRK 003	19903844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of FPR1 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FPR1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FPR1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FPR1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FPR1 mRNA"	25620056
D009532	Nickel	Nickel results in decreased expression of FPR1 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of FPR1 mRNA	24768652\|2558310
C510003	nordy	nordy results in decreased expression of FPR1	17459229
C046012	pentanal	pentanal results in increased expression of FPR1 mRNA	26079696
D011374	Progesterone	Progesterone affects the expression of FPR1 mRNA	17251523
C005556	propionaldehyde	propionaldehyde results in increased expression of FPR1 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FPR1 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of FPR1 mRNA	21602193
D012906	Smoke	Smoke results in increased expression of FPR1 mRNA	21095227
D053260	Soot	Soot results in decreased expression of FPR1 mRNA	22461453\|2655175
C016766	sulforafan	sulforafan results in increased expression of FPR1 mRNA	26833863
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of FPR1 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of FPR1 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FPR1 mRNA	28922406
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FPR1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FPR1 mRNA	26290441
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FPR1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of FPR1 mRNA	23557971\|2776080

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004875	complement receptor activity	-	IBA	21873635
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004982	N-formyl peptide receptor activity	-	IBA	21873635
GO:0004982	N-formyl peptide receptor activity	-	IDA	12218158 22859307
GO:0005124	scavenger receptor binding	-	IEA	-
GO:0005515	protein binding	-	IPI	22447027
GO:0050786	RAGE receptor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	TAS	10857861
GO:0002430	complement receptor mediated signaling pathway	-	IBA	21873635
GO:0006935	chemotaxis	-	TAS	10857861
GO:0006954	inflammatory response	-	IBA	21873635
GO:0007165	signal transduction	-	TAS	10820279
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	TAS	10889468
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	IDA	22859307
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0007263	nitric oxide mediated signal transduction	-	TAS	10861041
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0050900	leukocyte migration	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	ISS	-
GO:0005886	plasma membrane	-	ISS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	TAS	2161213
GO:0030667	secretory granule membrane	-	TAS	-
GO:0035577	azurophil granule membrane	-	TAS	-
GO:0101003	ficolin-1-rich granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa05150	Staphylococcus aureus infection

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21257786	Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease. (2011 May 1)	Sapey E	Am J Respir Crit Care Med
22461430	Genetic ablation of the fpr1 gene confers protection from smoking-induced lung emphysema in mice. (2012 Sep)	Cardini S	Am J Respir Cell Mol Biol
29544524	Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease. (2018 Mar 15)	Chen YC	J Transl Med
25277308	FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy. (2014 Dec)	Liang XY	Eye (Lond)