Gene: DDAH1

23576
DDAH|DDAH-1|DDAHI|HEL-S-16
dimethylarginine dimethylaminohydrolase 1
protein-coding
1p22.3
Ensembl:ENSG00000153904 MIM:604743 Vega:OTTHUMG00000191181 UniprotKB:O94760
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.591e-2 (AD)  5.169e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11161614chr1:85432477 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12278705chr1:86045474DDAH1Promoter1.927e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPE0.947
GLUD10.907
NEBL0.9
ITM2C0.899
ALDOC0.897
NADK20.896
SRI0.893
TMBIM60.891
PGM10.891
ABHD17C0.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.765
OR4F29-0.725
GADL1-0.324
DPPA4-0.292
FER1L6-0.278
OR6C74-0.278
CLEC6A-0.272
FOXI2-0.272
KRTAP9-3-0.269
OR5M9-0.264

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00155L-CitrullineSmall Molecule372-75-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of DDAH1 mRNA"26377693
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in increased expression of DDAH1 mRNA"17070881
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of DDAH1 mRNA"19784758
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of DDAH1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DDAH1 mRNA"22698814
C0353141-nitropropane1-nitropropane results in decreased expression of DDAH1 mRNA17070881
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DDAH1 mRNA"19114083
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of DDAH1 mRNA"21724226
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of DDAH1 mRNA"17070881
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DDAH1 mRNA"21346803
C0252352,6-diaminotoluene"2,6-diaminotoluene results in increased expression of DDAH1 mRNA"17070881
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DDAH1 mRNA"21346803
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in increased expression of DDAH1 mRNA17070881
C0194992-nitrofluorene2-nitrofluorene results in increased expression of DDAH1 mRNA15890375
C0166172-nitropropane2-nitropropane results in increased expression of DDAH1 mRNA17070881
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDAH1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH1 mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of DDAH1 mRNA17070881
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of DDAH1 mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DDAH1 mRNA15890375
C0293704-toluidine4-toluidine results in increased expression of DDAH1 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDAH1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DDAH1 mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of DDAH1 mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of DDAH1 mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of DDAH1 mRNA19784758
D020106AcrylamideAcrylamide results in increased expression of DDAH1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DDAH1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DDAH1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DDAH1 mRNA15890375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of DDAH1 mRNA28522335
D000499AllylamineAllylamine results in increased expression of DDAH1 mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DDAH1 mRNA16483693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDAH1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDAH1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene affects the expression of DDAH1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDAH1 mRNA23178640
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDAH1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DDAH1 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DDAH1 mRNA22610609
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDAH1 mRNA"20018196
D004958EstradiolEstradiol affects the expression of DDAH1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of DDAH1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of DDAH1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of DDAH1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of DDAH1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DDAH1 gene28505145
C584509C646 compoundC646 compound results in decreased expression of DDAH1 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DDAH1 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DDAH1 mRNA23178640
D002220CarbamazepineCarbamazepine affects the expression of DDAH1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DDAH1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DDAH1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DDAH1 mRNA19784758
D000068579CelecoxibCelecoxib results in increased expression of DDAH1 mRNA28201806
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DDAH1 mRNA28472532
C041167chromium nitratechromium nitrate results in decreased expression of DDAH1 protein22144121
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDAH1 mRNA27858113
D002994ClofibrateClofibrate results in increased expression of DDAH1 protein16470657
D003033Coal TarCoal Tar results in increased expression of DDAH1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDAH1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of DDAH1 mRNA24386269
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of DDAH1 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of DDAH1 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DDAH1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of DDAH1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of DDAH1 mRNA19770486
D013759DronabinolDronabinol results in increased expression of DDAH1 protein18584336
D003907DexamethasoneDexamethasone results in increased expression of DDAH1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DDAH1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DDAH1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of DDAH1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of DDAH1 mRNA18457598
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DDAH1 mRNA15890375
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of DDAH1 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of DDAH1 mRNA15890375
D004237DiuronDiuron results in decreased expression of DDAH1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DDAH1 mRNA17557909
D005419FlavonoidsFlavonoids results in increased expression of DDAH1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of DDAH1 mRNA17070881
D005485FlutamideFlutamide results in decreased expression of DDAH1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of DDAH1 mRNA17938736|2414096
D005557FormaldehydeFormaldehyde results in decreased expression of DDAH1 protein24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased expression of BAX protein]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased expression of CASP3 protein modified form]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased expression of DDIT3 protein]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased expression of PARP1 protein modified form]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased phosphorylation of EIF2AK3 protein]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased phosphorylation of EIF2A protein]24140967
D005557FormaldehydeDDAH1 protein inhibits the reaction [Formaldehyde results in increased phosphorylation of ERN1 protein]24140967
D005557FormaldehydeDDAH1 protein results in decreased susceptibility to Formaldehyde24140967
C039281furanfuran results in increased expression of DDAH1 mRNA26194646
D017313FenretinideFenretinide results in decreased expression of DDAH1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of DDAH1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of DDAH1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDAH1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DDAH1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DDAH1 mRNA27392435
D007854LeadLead affects the expression of DDAH1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of DDAH1 mRNA20680508
C008261lead acetatelead acetate results in increased expression of DDAH1 mRNA11578147
D008345ManganeseManganese deficiency results in decreased expression of DDAH1 protein21312047
D008345ManganeseParoxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]21312047
D008694MethamphetamineMethamphetamine affects the expression of DDAH1 protein17904249
D008701MethapyrileneMethapyrilene results in increased expression of DDAH1 mRNA15890375
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DDAH1 mRNA23179753|2800136
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DDAH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DDAH1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DDAH1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DDAH1 mRNA"25554681
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of DDAH1 mRNA19784758
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of DDAH1 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of DDAH1 protein19716841
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DDAH1 mRNA27935865
D000073878Palm OilPalm Oil results in decreased expression of DDAH1 mRNA18042831
D010269ParaquatParaquat results in increased expression of DDAH1 mRNA20388547
D017374ParoxetineParoxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]21312047
D010416PentachlorophenolPentachlorophenol results in decreased expression of DDAH1 mRNA23178640
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of DDAH1 protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DDAH1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of DDAH1 mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in decreased expression of DDAH1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DDAH1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DDAH1 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DDAH1 mRNA27935865
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of DDAH1 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of DDAH1 mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of DDAH1 mRNA15890375|1916217
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DDAH1 protein22144121
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DDAH1 mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of DDAH1 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of DDAH1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of DDAH1 mRNA24780913
D012524SarinSarin affects the expression of DDAH1 protein28973502
D019821SimvastatinSimvastatin results in decreased expression of DDAH1 mRNA16414398
C080703SK&F 83959SK&F 83959 results in increased expression of DDAH1 protein25852303
C017947sodium arsenitesodium arsenite affects the methylation of DDAH1 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of DDAH1 mRNA17879257
D013654TaurineTaurine results in decreased expression of DDAH1 mRNA16579726
C501413tesaglitazartesaglitazar results in increased expression of DDAH1 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDAH1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDAH1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DDAH1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DDAH1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DDAH1 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of DDAH1 protein"25852303
D019284ThapsigarginThapsigargin results in decreased expression of DDAH1 mRNA22378314
D013853ThioacetamideThioacetamide results in decreased expression of DDAH1 mRNA19784758
D013853ThioacetamideThioacetamide results in increased expression of DDAH1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of DDAH1 mRNA23557971|2776080
D014212TretinoinTretinoin results in decreased expression of DDAH1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DDAH1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DDAH1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of DDAH1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DDAH1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of DDAH1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DDAH1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of DDAH1 mRNA25423262
D015032ZincZinc binds to DDAH1 protein16698551
C088658zoledronic acidzoledronic acid results in decreased expression of DDAH1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS9874257  
GO:0016403dimethylargininase activity-IBA21873635  
GO:0016403dimethylargininase activity-IDA19663506  
GO:0016403dimethylargininase activity-TAS-  
GO:0016597amino acid binding-IBA21873635  
GO:0016597amino acid binding-IEA-  
GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000052citrulline metabolic process-IBA21873635  
GO:0000052citrulline metabolic process-IDA19663506  
GO:0003073regulation of systemic arterial blood pressure-ISS-  
GO:0006525arginine metabolic process-IBA21873635  
GO:0006527arginine catabolic process-IDA24895913  
GO:0007263nitric oxide mediated signal transduction-TAS9874257  
GO:0008285negative regulation of cell proliferation-IDA24895913  
GO:0043116negative regulation of vascular permeability-IDA24895913  
GO:0045429positive regulation of nitric oxide biosynthetic process-IBA21873635  
GO:0045429positive regulation of nitric oxide biosynthetic process-ISS-  
GO:0045766positive regulation of angiogenesis-IEA-  
GO:0050999regulation of nitric-oxide synthase activity-TAS-  
GO:1900038negative regulation of cellular response to hypoxia-IDA24895913  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-202131Metabolism of nitric oxideTAS
R-HSA-203615eNOS activationTAS
R-HSA-203765eNOS activation and regulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal