Gene: FPR2

2358
ALXR|FMLP-R-II|FMLPX|FPR2A|FPRH1|FPRH2|FPRL1|HM63|LXA4R
formyl peptide receptor 2
protein-coding
19q13.41
Ensembl:ENSG00000171049 MIM:136538 Vega:OTTHUMG00000183501 UniprotKB:P25090
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.174e-1 (AD)  3.529e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR80.867
GPR650.853
TREML20.841
CSF2RB0.834
PTPRC0.832
MYO1G0.83
CD1D0.827
TLR10.827
LILRB30.824
CCR50.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.494
NEUROD6-0.483
TMEM179-0.474
PVALB-0.468
EXTL1-0.464
ANKRD34A-0.46
BCL11A-0.456
MARCH4-0.455
CORT-0.453
SCRT1-0.452

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FPR2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of FPR2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FPR2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of FPR2 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FPR2 mRNA24449571
D001151ArsenicArsenic affects the methylation of FPR2 gene25304211
D001151ArsenicArsenic results in decreased expression of FPR2 mRNA19654921
D001241Aspirin[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR219597002
D001241AspirinAspirin results in increased expression of FPR219597002
C547126AZM551248AZM551248 results in decreased expression of FPR2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of FPR2 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FPR2 mRNA22228805
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of FPR2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of FPR2 mRNA26496021
C026690cerous chloridecerous chloride results in increased expression of FPR2 mRNA23573234
D002737ChloropreneChloroprene results in decreased expression of FPR2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of FPR2 mRNA23052192
D003520CyclophosphamideCyclophosphamide results in increased expression of FPR2 mRNA15331540
D016572CyclosporineCyclosporine results in increased methylation of FPR2 promoter27989131
D002945CisplatinCisplatin results in increased expression of FPR2 mRNA27594783
D004008DiclofenacDiclofenac results in increased expression of FPR2 mRNA26934552
C546771gardiquimodgardiquimod results in increased expression of FPR2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FPR2 mRNA]28003376
D017313FenretinideFenretinide results in increased expression of FPR2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FPR2 mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA"21765620
C482199lipopolysaccharide, E coli O55-B5"lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]"21765620
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FPR2 mRNA21831303
C040527lipoxin A4[Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR219597002
C040527lipoxin A4lipoxin A4 analog binds to and results in decreased activity of FPR2 protein12594298
C040527lipoxin A4lipoxin A4 results in increased activity of FPR212594298
C040527lipoxin A4"lipoxin A4 inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of FPR2 mRNA]"21765620
C040527lipoxin A4lipoxin A4 binds to FPR2 protein20709806
D008727MethotrexateMethotrexate results in decreased expression of FPR2 mRNA17400583
C523799MRK 003FPR2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of FPR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FPR2 mRNA"25554681
D009532NickelNickel results in decreased expression of FPR2 mRNA23195993
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of FPR2 mRNA27935865
C510003nordynordy results in decreased expression of FPR2 protein16516855
C006253pirinixic acidpirinixic acid results in decreased expression of FPR2 mRNA20813756
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FPR2 mRNA]28003376
D011794QuercetinQuercetin results in increased expression of FPR2 mRNA15309432
C518399resolvin D1resolvin D1 binds to and results in increased expression of FPR2 protein21724996
D012822Silicon DioxideSilicon Dioxide results in increased expression of FPR2 mRNA23221170
D053260SootSoot results in decreased expression of FPR2 mRNA26551751
C016766sulforafansulforafan results in increased expression of FPR2 mRNA26833863
D013629TamoxifenTamoxifen affects the expression of FPR2 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FPR2 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FPR2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FPR2 mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FPR2 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of FPR2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of FPR2 mRNA23409001
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of FPR2 mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FPR2 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of FPR2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004875complement receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-NAS11316806  20141570  
GO:0004982N-formyl peptide receptor activity-IBA21873635  
GO:0005124scavenger receptor binding-IPI20141570  
GO:0038024cargo receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-ISS-  
GO:0001934positive regulation of protein phosphorylation-IGI20141570  
GO:0002430complement receptor mediated signaling pathway-IBA21873635  
GO:0006898receptor-mediated endocytosis-ISS-  
GO:0006935chemotaxis-TAS9054386  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-TAS9054386  
GO:0007155cell adhesion-TAS9054386  
GO:0007186G-protein coupled receptor signaling pathway-IGI11160457  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IGI20141570  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-ISS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0019722calcium-mediated signaling-IGI11160457  
GO:0032930positive regulation of superoxide anion generation-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0048143astrocyte activation-ISS-  
GO:0050900leukocyte migration-IBA21873635  
GO:0050918positive chemotaxis-ISS-  
GO:0061903positive regulation of 1-phosphatidylinositol-3-kinase activity-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IGI20141570  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:0090026positive regulation of monocyte chemotaxis-IGI11160457  
GO:1904646cellular response to amyloid-beta-IDA11316806  
GO:1904646cellular response to amyloid-beta-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-ISS-  
GO:0005737cytoplasmcolocalizes_withIDA11689470  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membranecolocalizes_withIDA11689470  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS9054386  
GO:0035579specific granule membrane-TAS-  
GO:0070821tertiary granule membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-444473Formyl peptide receptors bind formyl peptides and many other ligandsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29544524Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease. (2018 Mar 15)Chen YCJ Transl Med
22215599Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease. (2012 Jan 17)Bozinovski SProc Natl Acad Sci U S A