Gene: SMUG1

23583
FDG|HMUDG|UNG3
single-strand-selective monofunctional uracil-DNA glycosylase 1
protein-coding
12q13.13
Ensembl:ENSG00000123415 MIM:607753 Vega:OTTHUMG00000160068 UniprotKB:Q53HV7
NG_047137.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.992e-1 (AD)  9.295e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARMC60.927
ANAPC70.924
TMEM2030.919
COPS7A0.919
CHMP70.916
COMMD90.915
MCRS10.914
MAEA0.913
BABAM10.912
MRPS170.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.624
OR4F29-0.571
MTRNR2L6-0.411
CNN2-0.402
PPBP-0.402
IL18RAP-0.399
MTRNR2L9-0.396
TBX15-0.395
CLEC2B-0.392
S100A12-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SMUG1 mRNA"19114083
C0268323,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene"3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene results in increased expression of SMUG1 mRNA"22236718
C0108895-chlorouracilSMUG1 protein affects the metabolism of 5-chlorouracil20104909
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SMUG1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SMUG1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SMUG1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SMUG1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of SMUG1 mRNA22378314
C006780bisphenol Abisphenol A results in increased methylation of SMUG1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of SMUG1 gene28505145
D019327Copper SulfateCopper Sulfate results in decreased expression of SMUG1 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of SMUG1 mRNA21878529
C014347decitabinedecitabine affects the expression of SMUG1 mRNA23300844
D002945CisplatinCisplatin affects the expression of SMUG1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SMUG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SMUG1 mRNA27392435
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of SMUG1 mRNA]22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMUG1 mRNA22079256
C069837fullerene C60fullerene C60 results in decreased expression of SMUG1 mRNA19167457
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SMUG1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SMUG1 mRNA27392435
D007854LeadLead results in increased expression of SMUG1 mRNA19921347
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SMUG1 mRNA"26251327
C027373potassium chromate(VI)epigallocatechin gallate inhibits the reaction [potassium chromate(VI) results in decreased expression of SMUG1 mRNA]22079256
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMUG1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SMUG1 mRNA22079256
D012969Sodium FluorideSodium Fluoride results in decreased expression of SMUG1 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMUG1 mRNA21570461
D014520UrethaneUrethane results in decreased expression of SMUG1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SMUG1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SMUG1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SMUG1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SMUG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000703oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0004844uracil DNA N-glycosylase activity-IBA21873635  
GO:0004844uracil DNA N-glycosylase activity-IDA12718543  
GO:0005515protein binding-IPI16189514  25416956  26871637  
GO:0017065single-strand selective uracil DNA N-glycosylase activity-IDA12161446  12718543  
GO:0017065single-strand selective uracil DNA N-glycosylase activity-TAS-  
GO:0019104DNA N-glycosylase activity-IDA11526119  
GO ID GO Term Qualifier Evidence PubMed
GO:0006284base-excision repair-IDA12161446  
GO:0045008depyrimidination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA12161446  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidineTAS
R-HSA-110329Cleavage of the damaged pyrimidine TAS
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73928DepyrimidinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27602958Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. (2016 Oct 25)Freeman JROncotarget