Gene: FPR3

2359
FML2_HUMAN|FMLP-R-II|FMLPY|FPRH1|FPRH2|FPRL2|RMLP-R-I
formyl peptide receptor 3
protein-coding
19q13.41
Ensembl:ENSG00000187474 MIM:136539 Vega:OTTHUMG00000183502 UniprotKB:P25089
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.288e-1 (AD)  2.457e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR80.867
ARL110.854
TLR10.843
ARHGAP150.842
NOD20.835
MS4A4A0.829
KYNU0.828
DAPP10.825
TFEC0.824
GPR650.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.405
CPLX3-0.4
HRH3-0.386
WNT7A-0.374
CHRNA4-0.373
ASPDH-0.37
WFDC1-0.368
ATP2C2-0.366
C15orf59-0.364
KCNK4-0.359

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FPR3 mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of FPR3 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FPR3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FPR3 mRNA24449571
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of FPR3 mRNA18192240
C006780bisphenol Abisphenol A results in decreased expression of FPR3 mRNA25181051
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA]18200517
D002117CalcitriolCalcitriol results in decreased expression of FPR3 mRNA26485663
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FPR3 mRNA21831303
D009532NickelNickel results in increased expression of FPR3 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of FPR3 mRNA22714537
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of FPR3 mRNA18200517

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004875complement receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004982N-formyl peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002430complement receptor mediated signaling pathway-IBA21873635  
GO:0006954inflammatory response-IBA21873635  
GO:0007165signal transduction-TAS8198572  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007204positive regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0050900leukocyte migration-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS8198572  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-444473Formyl peptide receptors bind formyl peptides and many other ligandsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29544524Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease. (2018 Mar 15)Chen YCJ Transl Med