Gene: AMACR

23600
AMACRD|CBAS4|P504S|RACE|RM
alpha-methylacyl-CoA racemase
protein-coding
5p13.2
Ensembl:ENSG00000242110 MIM:604489 Vega:OTTHUMG00000090734 UniprotKB:Q9UHK6
NG_016211.1
PubMed
0   ANCO-SNPs
ND
2   
3.174e-1 (AD)  6.813e-1 (ND)   (Frontal_Cortex)
8.667e-1 (AD)  5.524e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COA10.813
HMG20A0.808
BRWD10.802
NIPSNAP3B0.801
PPP1R20.798
DYNLT30.796
SNX140.796
RBM110.791
ZNF250.791
RAB11A0.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.447
OR4F29-0.407
EVC2-0.398
WDR38-0.385
SERPINH1-0.359
FOXJ1-0.349
ZBTB20-0.335
C7orf61-0.333
FAM151A-0.328
MTRNR2L6-0.327

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AMACR mRNA"17690111
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of AMACR protein22527513
C0415071-methylphenanthrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of AMACR mRNA17690111
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AMACR mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AMACR mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMACR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMACR mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of AMACR mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of AMACR mRNA15084756
D000111AcetylcysteineAcetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA]18829485
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AMACR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AMACR mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog affects the expression of AMACR protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of AMACR protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AMACR mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of AMACR mRNA26705709
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AMACR mRNA"17690111
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of AMACR mRNA17690111
D001564Benzo(a)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of AMACR mRNA"17690111
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AMACR mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AMACR mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of AMACR mRNA20106945
C053541bicalutamidebicalutamide results in decreased expression of AMACR mRNA15638997
C006780bisphenol Abisphenol A results in increased expression of AMACR mRNA25181051
C025703bleomycetinbleomycetin results in decreased expression of AMACR mRNA21040473
C018475butyraldehydebutyraldehyde results in decreased expression of AMACR mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of AMACR mRNA27339419
D002713ChlorineChlorine results in increased expression of AMACR mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of AMACR mRNA18636392
D002994ClofibrateClofibrate results in increased expression of AMACR protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of AMACR mRNA19376846
D003300CopperCopper results in decreased expression of AMACR mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of AMACR mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of AMACR mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of AMACR mRNA23830897
C041517dibenzo(a,l)pyrene"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of AMACR mRNA"17690111
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AMACR mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AMACR mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AMACR mRNA27392435
D002945CisplatinCisplatin results in increased expression of AMACR mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AMACR mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AMACR mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of AMACR mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of AMACR mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of AMACR mRNA17072980|2538013
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of AMACR mRNA25198161
C039281furanfuran results in decreased expression of AMACR mRNA15120968
D005897GlafenineGlafenine results in decreased expression of AMACR mRNA24136188
C029424hydrazinehydrazine results in decreased expression of AMACR mRNA15370871
D007052IbuprofenAMACR gene SNP affects the susceptibility to Ibuprofen17680641
D007052IbuprofenAMACR protein results in increased metabolism of and results in increased activity of Ibuprofen17680641
D007052IbuprofenAMACR protein results in increased metabolism of Ibuprofen17684125
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AMACR mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AMACR mRNA27392435
C544151jinfukangjinfukang results in increased expression of AMACR mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AMACR mRNA25307878
D008627Mercuric Chloride"[NOG protein co-treated with Mercuric Chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AMACR mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of AMACR mRNA16507785
D008701MethapyrileneMethapyrilene results in decreased expression of AMACR mRNA15120968|2852906
D008727MethotrexateMethotrexate results in increased expression of AMACR mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of AMACR mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AMACR mRNA28001369
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of AMACR mRNA25380136
C022838nickel chloridenickel chloride affects the expression of AMACR mRNA22110744
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of AMACR protein19716841
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of AMACR mRNA18636392
D017239PaclitaxelPaclitaxel results in increased expression of AMACR mRNA15585946
D010634PhenobarbitalPhenobarbital results in decreased expression of AMACR mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of AMACR mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of AMACR mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AMACR mRNA19162173
C107773pterostilbenepterostilbene results in decreased expression of AMACR mRNA20152895
D011794QuercetinQuercetin results in decreased expression of AMACR mRNA20596804
D015474IsotretinoinIsotretinoin results in decreased expression of AMACR mRNA20436886
D012524SarinSarin results in decreased expression of AMACR mRNA19522546
D012834SilverSilver results in increased expression of AMACR mRNA27131904
D012999SomanSoman results in decreased expression of AMACR mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of AMACR mRNA21592394
D013739TestosteroneTestosterone results in increased expression of AMACR mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AMACR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to AMACR gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AMACR mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AMACR mRNA26232522
D013752TetracyclineTetracycline results in decreased expression of AMACR mRNA24489787
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AMACR mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of AMACR mRNA26217789
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AMACR mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of AMACR mRNA23411599|2622270
C012589trichostatin Atrichostatin A results in decreased expression of AMACR mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of AMACR mRNA25979313
D014640VancomycinVancomycin results in increased expression of AMACR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AMACR gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of AMACR mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of AMACR mRNA"25198161
D015032ZincZinc deficiency results in decreased expression of AMACR mRNA15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI20178365  
GO:0008111alpha-methylacyl-CoA racemase activity-IDA7649182  
GO:0008111alpha-methylacyl-CoA racemase activity-IMP10655068  
GO:0008111alpha-methylacyl-CoA racemase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006699bile acid biosynthetic process-IEA-  
GO:0006699bile acid biosynthetic process-TAS-  
GO:0008206bile acid metabolic process-IDA10655068  
GO:0033540fatty acid beta-oxidation using acyl-CoA oxidase-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15941950  
GO:0005739mitochondrion-IDA7649182  20102405  
GO:0005777peroxisome-IDA7649182  
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00120Primary bile acid biosynthesis
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolTAS
R-HSA-193775Synthesis of bile acids and bile salts via 24-hydroxycholesterolTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-389887Beta-oxidation of pristanoyl-CoATAS
R-HSA-390918Peroxisomal lipid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26281327The expression and clinical effects of alpha-methylacyl-CoA racemase (AMACR/ P504S) as an immunohistochemical marker in malign pleural mesothelioma. (2015)Duyar SSTurk J Med Sci
20445798Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women. (2009)Van Dyke ALJ Cancer Epidemiol