Gene: CD2AP

23607
CMS
CD2 associated protein
protein-coding
6p12.3
Ensembl:ENSG00000198087 MIM:604241 Vega:OTTHUMG00000014799 UniprotKB:Q9Y5K6
NG_008878.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.683e-1 (AD)  5.221e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MALT10.868
TMOD30.854
NUP1600.846
BNIP20.844
ELK40.844
CFLAR0.834
CNTLN0.832
MOB1A0.831
DENND4C0.827
ATP10D0.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.379
GGN-0.377
CPLX3-0.37
CRH-0.368
OR4F29-0.361
GSG1-0.359
OR4F5-0.352
KCNG2-0.343
NANOS3-0.342
ASPDH-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CD2AP mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CD2AP mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of CD2AP mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of CD2AP mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD2AP mRNA16483693
D001151ArsenicArsenic affects the methylation of CD2AP gene25304211
C547126AZM551248AZM551248 results in increased expression of CD2AP mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD2AP mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of CD2AP mRNA25181051|2757113
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CD2AP mRNA24982889
D002220CarbamazepineCarbamazepine affects the expression of CD2AP mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD2AP mRNA27339419
D000068579CelecoxibCelecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]19194550
C018021cobaltous chloridecobaltous chloride results in decreased expression of CD2AP mRNA19320972
C057862cyanoginosin LRcyanoginosin LR results in increased expression of CD2AP mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of CD2AP mRNA19770486
D002945CisplatinCisplatin results in increased expression of CD2AP mRNA21151649
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CD2AP mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CD2AP mRNA24535843
D004317DoxorubicinDoxorubicin results in increased expression of CD2AP mRNA16636307
D004317DoxorubicinDoxorubicin results in increased expression of CD2AP protein16636307
D004317DoxorubicinLisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307
D004317DoxorubicinPrednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]16636307
D004317DoxorubicinPrednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307
D004317DoxorubicinTretinoin affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]16636307
D004317DoxorubicinTretinoin inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CD2AP protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CD2AP mRNA22079256
D005839GentamicinsGentamicins results in increased expression of CD2AP mRNA22061828
C544151jinfukangjinfukang results in decreased expression of CD2AP mRNA27392435
C410337K 7174K 7174 results in increased expression of CD2AP mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CD2AP mRNA"24972896
D017706LisinoprilLisinopril inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CD2AP mRNA23179753
D016627OxidopamineOxidopamine results in increased expression of CD2AP mRNA18535749
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD2AP mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD2AP protein26879310
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CD2AP mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of CD2AP mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of CD2AP mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CD2AP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CD2AP mRNA22079256
D011241PrednisonePrednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]16636307
D011241PrednisonePrednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307
D011691PuromycinPuromycin results in decreased expression of CD2AP mRNA15673299
D011692Puromycin AminonucleosideCelecoxib inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of CD2AP mRNA]19194550
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of CD2AP mRNA19194550
D019821SimvastatinSimvastatin results in increased expression of CD2AP mRNA16710349
C009277sodium arsenatesodium arsenate results in increased expression of CD2AP mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD2AP mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD2AP mRNA19770486
D013853ThioacetamideThioacetamide results in increased expression of CD2AP mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of CD2AP mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of CD2AP mRNA"19682533
D014212TretinoinTretinoin affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]16636307
D014212TretinoinTretinoin inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein]16636307

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005172vascular endothelial growth factor receptor binding-IEA-  
GO:0005200structural constituent of cytoskeleton-TAS10339567  
GO:0005515protein binding-IPI9741631  10339567  11067845  17020880  17853893  18641129  
19380743  21706016  21822214  21988832  22662192  22891260  
23663663  25036637  
GO:0008013beta-catenin binding-IEA-  
GO:0008022protein C-terminus binding-IEA-  
GO:0017124SH3 domain binding-IPI10339567  
GO:0044877protein-containing complex binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0006930substrate-dependent cell migration, cell extension-TAS10339567  
GO:0007015actin filament organization-IMP22891260  
GO:0007049cell cycle-IEA-  
GO:0007165signal transduction-NAS10339567  
GO:0016050vesicle organization-IEA-  
GO:0032911negative regulation of transforming growth factor beta1 production-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IEA-  
GO:0048259regulation of receptor-mediated endocytosis-IEA-  
GO:0051058negative regulation of small GTPase mediated signal transduction-IMP22891260  
GO:0051301cell division-IEA-  
GO:0065003protein-containing complex assembly-TAS10339567  
GO:0098609cell-cell adhesion-IEA-  
GO:1900182positive regulation of protein localization to nucleus-IEA-  
GO:2000249regulation of actin cytoskeleton reorganization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IDA10339567  
GO:0005737cytoplasm-TAS10339567  
GO:0005886plasma membrane-IEA-  
GO:0005911cell-cell junction-IEA-  
GO:0015629actin cytoskeleton-TAS10339567  
GO:0030139endocytic vesicle-IEA-  
GO:0031941filamentous actin-IDA10339567  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-373753Nephrin family interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget